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    Edc4 enhancer of mRNA decapping 4 [ Mus musculus (house mouse) ]

    Gene ID: 234699, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Edc4provided by MGI
    Official Full Name
    enhancer of mRNA decapping 4provided by MGI
    Primary source
    MGI:MGI:2446249
    See related
    Ensembl:ENSMUSG00000036270 AllianceGenome:MGI:2446249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene is thought to promote mRNA decay, and is known to interact with several mRNA decapping proteins. In humans, decreased expression of this gene prevents the accumulation of mRNA decapping proteins to mRNA processing bodies (P-body). Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in thymus adult (RPKM 38.7), ovary adult (RPKM 33.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Edc4 in Genome Data Viewer
    Location:
    8 D3; 8 53.05 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106607506..106619857)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105880873..105893225)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3799 Neighboring gene THAP domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_22544 Neighboring gene nuclear transport factor 2 Neighboring gene STARR-seq mESC enhancer starr_22545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108404648-108404831 Neighboring gene STARR-positive B cell enhancer ABC_E3800 Neighboring gene neuritin 1-like Neighboring gene protein serine kinase H1 Neighboring gene STARR-positive B cell enhancer ABC_E6679

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The immunoreactive region in a novel autoantigen contains a nuclear localization sequence. Bloch DB, et al. Clin Immunol Immunopathol, 1994 Sep. PMID 7520377
    2. Ge-1 is a central component of the mammalian cytoplasmic mRNA processing body. Yu JH, et al. RNA, 2005 Dec. PMID 16314453, Free PMC Article
    3. Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Glasmacher E, et al. Nat Immunol, 2010 Aug. PMID 20639877
    4. CCHCR1 interacts with EDC4, suggesting its localization in P-bodies. Ling YH, et al. Exp Cell Res, 2014 Sep 10. PMID 24858563
    5. MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. Unhavaithaya Y, et al. J Biol Chem, 2009 Mar 6. PMID 19114715, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of mRNA-decapping protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301100.2 → NP_001288029.1  enhancer of mRNA-decapping protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001288029.1

      Status: REVIEWED

      Source sequence(s)
      AC159265
      Consensus CDS
      CCDS80923.1
      UniProtKB/Swiss-Prot
      Q3U6U8, Q3UJB9, Q7TS78, Q8R223
      UniProtKB/TrEMBL
      G5E896
      Related
      ENSMUSP00000039134.10, ENSMUST00000040254.16
      Conserved Domains (3) summary
      pfam16529
      Location:114 → 440
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      sd00039
      Location:304 → 343
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:260 → 409
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001404070.1 → NP_001390999.1  enhancer of mRNA-decapping protein 4 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC159265
      UniProtKB/Swiss-Prot
      Q3U6U8, Q3UJB9, Q7TS78, Q8R223

    3. NM_001404071.1 → NP_001391000.1  enhancer of mRNA-decapping protein 4 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC159265
      UniProtKB/Swiss-Prot
      Q3U6U8, Q3UJB9, Q7TS78, Q8R223

    4. NM_001404072.1 → NP_001391001.1  enhancer of mRNA-decapping protein 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC159265
      UniProtKB/Swiss-Prot
      Q3U6U8, Q3UJB9, Q7TS78, Q8R223

    5. NM_001404073.1 → NP_001391002.1  enhancer of mRNA-decapping protein 4 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC159265
      UniProtKB/Swiss-Prot
      Q3U6U8, Q3UJB9, Q7TS78, Q8R223

    6. NM_001404074.1 → NP_001391003.1  enhancer of mRNA-decapping protein 4 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC159265
      UniProtKB/Swiss-Prot
      Q3U6U8, Q3UJB9, Q7TS78, Q8R223

    7. NM_181594.4 → NP_853625.1  enhancer of mRNA-decapping protein 4 isoform 2

      See identical proteins and their annotated locations for NP_853625.1

      Status: REVIEWED

      Source sequence(s)
      AC159265
      Consensus CDS
      CCDS52662.1
      UniProtKB/Swiss-Prot
      Q3U6U8, Q3UJB9, Q7TS78, Q8R223
      UniProtKB/TrEMBL
      A0A0R4J1Q0
      Related
      ENSMUSP00000113854.2, ENSMUST00000119261.8
      Conserved Domains (3) summary
      pfam16529
      Location:114 → 440
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
      sd00039
      Location:304 → 343
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:260 → 409
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106607506..106619857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312743.2 → XP_017168232.1  enhancer of mRNA-decapping protein 4 isoform X3

      UniProtKB/Swiss-Prot
      Q3U6U8, Q3UJB9, Q7TS78, Q8R223
      Conserved Domains (2) summary
      sd00039
      Location:304 → 343
      7WD40; WD40 repeat [structural motif]
      pfam16529
      Location:114 → 440
      Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein

    2. XM_006530905.4 → XP_006530968.1  enhancer of mRNA-decapping protein 4 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UJB9.2 GenPept UniProtKB/Swiss-Prot:Q3UJB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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