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    KRTAP5-10 keratin associated protein 5-10 [ Homo sapiens (human) ]

    Gene ID: 387273, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KRTAP5-10provided by HGNC
    Official Full Name
    keratin associated protein 5-10provided by HGNC
    Primary source
    HGNC:HGNC:23605
    See related
    Ensembl:ENSG00000204572 AllianceGenome:HGNC:23605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KRTAP5.10
    Summary
    Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KRTAP5-10 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (71565563..71566735)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71276609..71277781)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene keratin associated protein 5-8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71259339-71259884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71259885-71260429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5170 Neighboring gene keratin associated protein 5-9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71276996-71277811 Neighboring gene keratin associated protein 5-13, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71289681-71290194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71290195-71290706 Neighboring gene keratin associated protein 5-14, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. Yahagi S, et al. Biochem Biophys Res Commun, 2004 Jun 4. PMID 15144888
    2. Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7. Baxter JS, et al. Mol Oncol, 2024 Feb. PMID 37866880, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin-associated protein 5-10
    Names
    keratin-associated protein 5.10
    ultrahigh sulfur keratin-associated protein 5.10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012710.2 → NP_001012728.1  keratin-associated protein 5-10

      See identical proteins and their annotated locations for NP_001012728.1

      Status: VALIDATED

      Source sequence(s)
      AB126079, AP000867
      Consensus CDS
      CCDS41684.1
      UniProtKB/Swiss-Prot
      B9EHA4, Q6L8G5
      Related
      ENSP00000381542.1, ENST00000398531.3
      Conserved Domains (1) summary
      pfam13885
      Location:174 → 199
      Keratin_B2_2; Keratin, high sulfur B2 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      71565563..71566735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6L8G5.1 GenPept UniProtKB/Swiss-Prot:Q6L8G5

    Gene LinkOut

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