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    Aox2 aldehyde oxidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 213043, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Aox2provided by MGI
    Official Full Name
    aldehyde oxidase 2provided by MGI
    Primary source
    MGI:MGI:3529596
    See related
    Ensembl:ENSMUSG00000079554 AllianceGenome:MGI:3529596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aoh3; Aox3l1
    Summary
    Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and protein homodimerization activity. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol. Is expressed in nervous system; nose; and olfactory epithelium. Orthologous to human AOX2P (aldehyde oxidase 2, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Aox2 in Genome Data Viewer
    Location:
    1 C1.3; 1 29.0 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58317485..58418423)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58278326..58379264)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene aldehyde oxidase 3 Neighboring gene predicted gene, 24548 Neighboring gene aldehyde oxidase 4 Neighboring gene predicted gene 15759 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58450605-58450792 Neighboring gene predicted gene, 53481 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene basic leucine zipper and W2 domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases. Cerqueira NM, et al. J Biol Inorg Chem, 2015 Mar. PMID 25287365
    2. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki M, et al. J Biol Chem, 2004 Nov 26. PMID 15383531
    3. Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Kurosaki M, et al. Cell Mol Life Sci, 2013 May. PMID 23263164, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
      Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
    2. selectively expressed in Bowman's glands of the olfactory mucosa
      Title: The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables flavin adenine dinucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molybdopterin cofactor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde oxidase 2
    Names
    aldehyde oxidase 3-like 1
    aldehyde oxidase homolog 3
    aldehyde oxidase-like protein 3
    azaheterocycle hydroxylase 2
    NP_001008419.1
    XP_017175142.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008419.2 → NP_001008419.1  aldehyde oxidase 2

      See identical proteins and their annotated locations for NP_001008419.1

      Status: VALIDATED

      Source sequence(s)
      AC121091, AC163498
      Consensus CDS
      CCDS35576.1
      UniProtKB/Swiss-Prot
      B9EKC6, Q5SGK3
      Related
      ENSMUSP00000110006.2, ENSMUST00000114366.3
      Conserved Domains (7) summary
      TIGR02969
      Location:10 → 1344
      mam_aldehyde_ox; aldehyde oxidase
      smart01008
      Location:604 → 706
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      cd00207
      Location:11 → 84
      fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
      pfam00941
      Location:241 → 421
      FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
      pfam01799
      Location:92 → 163
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:721 → 1251
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:428 → 532
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58317485..58418423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319653.3 → XP_017175142.1  aldehyde oxidase 2 isoform X1

      Conserved Domains (1) summary
      TIGR02969
      Location:10 → 1329
      mam_aldehyde_ox; aldehyde oxidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SGK3.2 GenPept UniProtKB/Swiss-Prot:Q5SGK3

    Gene LinkOut

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