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    LINC00174 long intergenic non-protein coding RNA 174 [ Homo sapiens (human) ]

    Gene ID: 285908, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00174provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 174provided by HGNC
    Primary source
    HGNC:HGNC:27788
    See related
    Ensembl:ENSG00000179406 AllianceGenome:HGNC:27788
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCRNA00174
    Expression
    Broad expression in testis (RPKM 4.6), skin (RPKM 2.7) and 24 other tissues See more
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    Genomic context

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    See LINC00174 in Genome Data Viewer
    Location:
    7q11.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (66376044..66400408, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (67598166..67620055, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (65841031..65865395, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65580214-65580742 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:65612993-65614192 Neighboring gene CGRP receptor component Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65642926-65643089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18205 Neighboring gene tyrosylprotein sulfotransferase 1 Neighboring gene MPRA-validated peak6545 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:65779787-65780442 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:65814565-65815064 Neighboring gene RNA, U6 small nuclear 313, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:65827447-65827611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853152-65853652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:65853653-65854153 Neighboring gene uncharacterized LOC124901822 Neighboring gene general transcription factor IIi pseudogene 9 Neighboring gene S-phase kinase associated protein 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00174 Promotes Colon Cancer Progression by Regulating Inflammation and Glycolysis by Targeting the MicroRNA-2467-3p/Enolase 3 Axis. Xu S, et al. Mediators Inflamm, 2023. PMID 37448887, Free PMC Article
    2. LINC00174 is an oncogenic lncRNA of hepatocellular carcinoma and regulates miR-320/S100A10 axis. Zhao JT, et al. Cell Biochem Funct, 2020 Oct. PMID 32128852
    3. LINC00174 is a favorable prognostic biomarker in glioblastoma via promoting proliferative phenotype. Wang Z, et al. Cancer Biomark, 2020. PMID 32390602
    4. LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism. Tito C, et al. Cell Death Dis, 2020 Nov 7. PMID 33161413, Free PMC Article
    5. LINC00174 triggers the malignant development of breast cancer by negatively regulating miR-1827 level. Xu H, et al. Eur Rev Med Pharmacol Sci, 2021 Nov. PMID 34787848

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression.
      Title: c-JUN-induced upregulation of LINC00174 contributes to colorectal cancer proliferation and invasion through accelerating USP21 expression.
    2. LINC00174 Promotes Colon Cancer Progression by Regulating Inflammation and Glycolysis by Targeting the MicroRNA-2467-3p/Enolase 3 Axis.
      Title: LINC00174 Promotes Colon Cancer Progression by Regulating Inflammation and Glycolysis by Targeting the MicroRNA-2467-3p/Enolase 3 Axis.
    3. Expression of LINC00174 in different cancers: Review of the literature and bioinformatics analyses.
      Title: Expression of LINC00174 in different cancers: Review of the literature and bioinformatics analyses.
    4. [Effect of LINC00174 on the Malignant Proliferation of Multiple Myeloma Cells and Its Related Mechanism].
      Title: [Effect of LINC00174 on the Malignant Proliferation of Multiple Myeloma Cells and Its Related Mechanism].
    5. LINC00174 promotes cell proliferation and metastasis in renal clear cell carcinoma by regulating miR-612/FOXM1 axis.
      Title: LINC00174 promotes cell proliferation and metastasis in renal clear cell carcinoma by regulating miR-612/FOXM1 axis.
    6. Downregulated long intergenic non-coding RNA 00,174 represses malignant biological behaviors of lung cancer cells by regulating microRNA-584-3p/ribosomal protein S24 axis.
      Title: Downregulated long intergenic non-coding RNA 00,174 represses malignant biological behaviors of lung cancer cells by regulating microRNA-584-3p/ribosomal protein S24 axis.
    7. LINC00174 triggers the malignant development of breast cancer by negatively regulating miR-1827 level.
      Title: LINC00174 triggers the malignant development of breast cancer by negatively regulating miR-1827 level.
    8. LINC00174 Facilitates Proliferation and Migration of Colorectal Cancer Cells via MiR-3127-5p/ E2F7 Axis.
      Title: LINC00174 Facilitates Proliferation and Migration of Colorectal Cancer Cells via MiR-3127-5p/ E2F7 Axis.
    9. LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism.
      Title: LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism.
    10. LINC00174 is an oncogenic lncRNA of hepatocellular carcinoma and regulates miR-320/S100A10 axis.
      Title: LINC00174 is an oncogenic lncRNA of hepatocellular carcinoma and regulates miR-320/S100A10 axis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026873.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK091213, AK124597, AW008847, BC020399, DB067709
      Related
      ENST00000421767.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      66376044..66400408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      67598166..67620055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181722.2: Suppressed sequence

      Description
      NM_181722.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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