Ptbp1 polypyrimidine tract binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptbp1provided by MGI
Official Full Name: polypyrimidine tract binding protein 1provided by MGI
Primary source: MGI:MGI:97791
See related: Ensembl:ENSMUSG00000006498 AllianceGenome:MGI:97791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ptb; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1
Summary: Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome and negative regulation of neuron differentiation. Acts upstream of with a negative effect on gene expression. Acts upstream of or within neurogenesis and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; central nervous system ganglion; connective tissue; genitourinary system; and sensory organ. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 115.0), limb E14.5 (RPKM 113.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (79690502..79700269)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (79854432..79864435)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppression of PTBP1 in hippocampal astrocytes promotes neurogenesis and ameliorates recognition memory in mice with cerebral ischemia.
Title: Suppression of PTBP1 in hippocampal astrocytes promotes neurogenesis and ameliorates recognition memory in mice with cerebral ischemia.
A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.
Title: A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.
Circ-CCT2 Activates Wnt/beta-catenin Signaling to Facilitate Hepatoblastoma Development by Stabilizing PTBP1 mRNA.
Title: Circ-CCT2 Activates Wnt/β-catenin Signaling to Facilitate Hepatoblastoma Development by Stabilizing PTBP1 mRNA.
Ptbp1 knockdown failed to induce astrocytes to neurons in vivo.
Title: Ptbp1 knockdown failed to induce astrocytes to neurons in vivo.
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
Title: lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization.
Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid-binding protein 5.
Title: Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis by regulating fatty acid-binding protein 5.
PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression.
Title: PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression.
hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
Title: hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.
Sweet taste perception in mice is blunted by PTBP1-regulated skipping of Tas1r2 exon 4.
Title: Sweet taste perception in mice is blunted by PTBP1-regulated skipping of Tas1r2 exon 4.
LncRNA HOTAIR promotes myocardial fibrosis in atrial fibrillation through binding with PTBP1 to increase the stability of Wnt5a.
Title: LncRNA HOTAIR promotes myocardial fibrosis in atrial fibrillation through binding with PTBP1 to increase the stability of Wnt5a.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124575 (e-PCR)
- UniSTS:161397

NoName (e-PCR)
- UniSTS:236919

Ptb (e-PCR), detects polymorphism
- UniSTS:144286

Ptbp1 (e-PCR), detects polymorphism
- UniSTS:479212

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables regulatory region RNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in IRES-dependent viral translational initiation	ISO Inferred from Sequence Orthology more info
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_negative_effect gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of secretory granule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: polypyrimidine tract-binding protein 1

Names: heterogeneous nuclear ribonucleoprotein I; hnRNP I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077363.3 → NP_001070831.1 polypyrimidine tract-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_001070831.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC151846

Consensus CDS

CCDS35969.1

UniProtKB/Swiss-Prot

P17225, Q8BGJ5, Q922I7

UniProtKB/TrEMBL

Q5RJV5, Q6NZB8, Q8K144

Related

ENSMUSP00000126192.2, ENSMUST00000172282.8

Conserved Domains (1) summary

TIGR01649
Location:56 → 555

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
NM_001283013.2 → NP_001269942.1 polypyrimidine tract-binding protein 1 isoform 3

See identical proteins and their annotated locations for NP_001269942.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate segment and an exon in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.

Source sequence(s)

AC151846

Consensus CDS

CCDS70064.1

UniProtKB/TrEMBL

Q3T984, Q8CB58

Related

ENSMUSP00000093109.5, ENSMUST00000095457.11

Conserved Domains (3) summary

cd12693
Location:140 → 235

RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins

TIGR01649
Location:36 → 489

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

cl17169
Location:296 → 388

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001407385.1 → NP_001394314.1 polypyrimidine tract-binding protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC151846
NM_001407387.1 → NP_001394316.1 polypyrimidine tract-binding protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC151846
NM_001407389.1 → NP_001394318.1 polypyrimidine tract-binding protein 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC151846
NM_001407391.1 → NP_001394320.1 polypyrimidine tract-binding protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC151846
NM_001407393.1 → NP_001394322.1 polypyrimidine tract-binding protein 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC151846
NM_008956.4 → NP_032982.2 polypyrimidine tract-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_032982.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC151846

Consensus CDS

CCDS35970.1

UniProtKB/TrEMBL

Q3T984, Q3UBR5

Related

ENSMUSP00000127783.2, ENSMUST00000165704.8

Conserved Domains (1) summary

TIGR01649
Location:56 → 529

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family