5-HT1B 5-hydroxytryptamine (serotonin) receptor 1B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: 5-HT1Bprovided by FlyBase
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 1Bprovided by FlyBase
Primary source: FLYBASE:FBgn0263116
Locus tag: Dmel_CG15113
See related: AllianceGenome:FB:FBgn0263116
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5-HT; 5-HT-dro2B; 5-HT1b; 5-HT1BDro; 5-HT[1B]Dro; 5-HT[[1BDro]]; 5-HT[[1B]]; 5-HT[[1B]]Dro; 5-HT[[1B]]DRO; 5-HT[[dro2B]]; 5HT-1B; 5HT-dro2B; 5HT-dro[[2B]]; 5HT-R2B; 5HT1b; 5HT1B; 5HT1B-R; 5htdro2b; 5HTR1B; CG15113; CG30126; d5-HT1B; Dm5-HT1B; Dm5-HT[[1B]]; Dm5HTdro2B; Dmel\CG15113; DRO2B; HT1B
Old locus tag: Dmel_CG30126
Summary: Enables G protein-coupled serotonin receptor activity. Involved in G protein-coupled serotonin receptor signaling pathway; entrainment of circadian clock; and serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including Kenyon cell; brain; dopaminergic PPL1 neuron; ellipsoid body layer; and synaptic neuropil domain. Used to study generalized anxiety disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; anxiety disorder (multiple); depressive disorder (multiple); and substance abuse (multiple). Orthologous to several human genes including HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 56B1-56B1; 2-88 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19022325..19032642, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14909830..14920147, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serotonergic modulation of visual neurons in Drosophila melanogaster.
Title: Serotonergic modulation of visual neurons in Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled serotonin receptor activity	TAS Traceable Author Statement more info	PubMed
enables Gi/o-coupled serotonin receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5-hydroxytryptamine (serotonin) receptor 1B

Names: 5-HT1B-PA; 5-HT1B-PD; 5-HT1B-PE; CG15113-PA; CG15113-PD; CG15113-PE; drosophila serotonin receptor 1B; serotonin receptor 1B; serotonin receptor 2B