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    Ctif CBP80/20-dependent translation initiation factor [ Mus musculus (house mouse) ]

    Gene ID: 269037, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctifprovided by MGI
    Official Full Name
    CBP80/20-dependent translation initiation factorprovided by MGI
    Primary source
    MGI:MGI:2685518
    See related
    Ensembl:ENSMUSG00000052928 AllianceGenome:MGI:2685518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm672
    Summary
    Predicted to enable translation activator activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of translational initiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human CTIF (cap binding complex dependent translation initiation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 10.9), CNS E18 (RPKM 10.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctif in Genome Data Viewer
    Location:
    18 E3; 18 51.06 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (75564279..75830762, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (75431205..75697696, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45059 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:75537151-75537467 Neighboring gene STARR-seq mESC enhancer starr_45061 Neighboring gene predicted gene 20544 Neighboring gene SMAD family member 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:75579115-75579397 Neighboring gene predicted gene, 41776 Neighboring gene STARR-seq mESC enhancer starr_45075 Neighboring gene predicted gene, 52357 Neighboring gene VISTA enhancers mm18 and mm257 Neighboring gene STARR-seq mESC enhancer starr_45078 Neighboring gene predicted gene 10532 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:75722201-75722354 Neighboring gene STARR-positive B cell enhancer ABC_E5665 Neighboring gene RIKEN cDNA 1700034B16 gene Neighboring gene thymosin, beta 10 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation. Kim KM, et al. Genes Dev, 2009 Sep 1. PMID 19648179, Free PMC Article
    2. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC67202

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CBP80/20-dependent translation initiation factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408302.1 → NP_001395231.1  CBP80/20-dependent translation initiation factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113528, AC120156, AC120176
      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2

    2. NM_001408303.1 → NP_001395232.1  CBP80/20-dependent translation initiation factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113528, AC120156, AC120176
      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2

    3. NM_001408304.1 → NP_001395233.1  CBP80/20-dependent translation initiation factor isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113528, AC120156, AC120176
      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2

    4. NM_001408305.1 → NP_001395234.1  CBP80/20-dependent translation initiation factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113528, AC120156, AC120176
      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2
      UniProtKB/TrEMBL
      E9Q1U6

    5. NM_001408306.1 → NP_001395235.1  CBP80/20-dependent translation initiation factor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113528, AC120156, AC120176
      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2
      UniProtKB/TrEMBL
      E9Q1U6

    6. NM_001408307.1 → NP_001395236.1  CBP80/20-dependent translation initiation factor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113528, AC120156, AC120176
      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2

    7. NM_201354.3 → NP_958742.2  CBP80/20-dependent translation initiation factor isoform 2

      See identical proteins and their annotated locations for NP_958742.2

      Status: VALIDATED

      Source sequence(s)
      AC113528, AC120156, AC120176
      Consensus CDS
      CCDS37861.1
      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2
      UniProtKB/TrEMBL
      E9Q1U6
      Related
      ENSMUSP00000129974.2, ENSMUST00000165559.3
      Conserved Domains (2) summary
      PTZ00449
      Location:259 → 395
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam02854
      Location:402 → 602
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      75564279..75830762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525968.4 → XP_006526031.1  CBP80/20-dependent translation initiation factor isoform X1

      See identical proteins and their annotated locations for XP_006526031.1

      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2
      UniProtKB/TrEMBL
      E9Q1U6
      Conserved Domains (2) summary
      PTZ00449
      Location:259 → 395
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam02854
      Location:402 → 602
      MIF4G; MIF4G domain

    2. XM_036161162.1 → XP_036017055.1  CBP80/20-dependent translation initiation factor isoform X1

      UniProtKB/Swiss-Prot
      Q6A069, Q6PEE2
      UniProtKB/TrEMBL
      E9Q1U6
      Conserved Domains (2) summary
      PTZ00449
      Location:259 → 395
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam02854
      Location:402 → 602
      MIF4G; MIF4G domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PEE2.2 GenPept UniProtKB/Swiss-Prot:Q6PEE2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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