Isg15 ISG15 ubiquitin-like modifier [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Isg15provided by MGI
Official Full Name: ISG15 ubiquitin-like modifierprovided by MGI
Primary source: MGI:MGI:1855694
See related: Ensembl:ENSMUSG00000035692 AllianceGenome:MGI:1855694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G1p2; IP17; Irfp; UCRP; IGI15
Summary: Enables protein tag activity. Involved in several processes, including ISG15-protein conjugation; defense response to other organism; and positive regulation of erythrocyte differentiation. Acts upstream of or within modification-dependent protein catabolic process and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; decidua; embryo; labyrinthine zone; and mesometrium. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 20.5), placenta adult (RPKM 4.4) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 88.61 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (156283881..156285275, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (156199424..156200818, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFbetaR1 ISGylation.
Title: ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation.
ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Title: ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage.
Title: Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage.
Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1alpha signalling pathway.
Title: Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1α signalling pathway.
ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions.
Title: ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions.
ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma.
Title: ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma.
Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure.
Title: Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure.
ISGylation of NF-kappaBp65 by SCF[FBXL19] E3 Ligase Diminishes Endothelial Inflammation.
Title: ISGylation of NF-κBp65 by SCF(FBXL19) E3 Ligase Diminishes Endothelial Inflammation.
Free ISG15 inhibits Pseudorabies virus infection by positively regulating type I IFN signaling.
Title: Free ISG15 inhibits Pseudorabies virus infection by positively regulating type I IFN signaling.
Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages.
Title: Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (70)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tag activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tag activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tag activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ISG15-protein conjugation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ISG15-protein conjugation	IDA Inferred from Direct Assay more info	PubMed
involved_in ISG15-protein conjugation	IDA Inferred from Direct Assay more info	PubMed
involved_in ISG15-protein conjugation	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in modification-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within modification-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein oligomerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein oligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in protein localization to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to type I interferon	ISO Inferred from Sequence Orthology more info
involved_in response to type I interferon	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-like protein ISG15

Names: interferon, alpha-inducible protein; interferon-induced 15 kDa protein; interferon-induced 15-KDa protein; interferon-induced 17 kDa protein; interferon-stimulated protein (15 kDa); interferon-stimulated protein 15; ubiquitin cross-reactive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015783.3 → NP_056598.2 ubiquitin-like protein ISG15

See identical proteins and their annotated locations for NP_056598.2

Status: VALIDATED

Source sequence(s)

CT998563

Consensus CDS

CCDS51405.1

UniProtKB/Swiss-Prot

Q64339, Q8K0H3

UniProtKB/TrEMBL

Q4FJR9

Related

ENSMUSP00000082548.5, ENSMUST00000085425.6

Conserved Domains (2) summary

cd01792
Location:3 → 75

Ubl1_ISG15; ubiquitin-like (Ubl) domain 1 found in interferon-stimulated gene 15 (ISG15) and similar proteins

cd01810
Location:80 → 153

Ubl2_ISG15; ubiquitin-like (Ubl) domain 2 found in interferon-stimulated gene 15 (ISG15) and similar proteins