rho1 Rho family GTPase Rho1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: rho1
Official Full Name: Rho family GTPase Rho1
Primary source: PomBase:SPAC1F7.04
Locus tag: SPOM_SPAC1F7.04
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See rho1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_003424.3 (4224071..4225824)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fission Yeast Rho1p-GEFs: From Polarity and Cell Wall Synthesis to Genome Stability.
Title: Fission Yeast Rho1p-GEFs: From Polarity and Cell Wall Synthesis to Genome Stability.
both Rho1 and Pck1 are positive upstream regulatory members of the CIP in addition to Rho2 and Pck2.
Title: Rho1 GTPase and PKC ortholog Pck1 are upstream activators of the cell integrity MAPK pathway in fission yeast.
All together our results suggest that loss of Rho1 function causes an increase in the cell integrity MAPK activity, which is detrimental to the cells and turns calcineurin activity essential
Title: Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.
The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway.
Title: The fission yeast cell wall stress sensor-like proteins Mtl2 and Wsc1 act by turning on the GTPase Rho1p but act independently of the cell wall integrity pathway.
Rgf1p and Rgf2p are alternative guanine nucleotide exchange factors with an essential overlapping function in Rho1p activation during vegetative growth.
Title: Fission yeast rgf2p is a rho1p guanine nucleotide exchange factor required for spore wall maturation and for the maintenance of cell integrity in the absence of rgf1p.
Results show that Rgf1p, a Rho1p-specific GEF, acts upstream from the Pck2-Pmk1p MAPK cell integrity signaling pathway.
Title: The Rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast.
Rgf1p probably activates the Rho1 functions necessary for coordinating actin deposition with cell wall biosynthesis during bipolar growth, allowing the cells to remodel their wall without risk of rupture.
Title: Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.
Rgf3p acts as a positive activator of Rho1p, probably activating the Rho functions that coordinate cell-wall biosynthesis to maintain cell integrity during septation
Title: Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynthesis through the GTPase Rho1p.
Results suggest that the small GTPase Rho5 has an overlapping function with the small GTPase Rho1 in controlling cell growth and division.
Title: Small GTPase Rho5 is a functional homologue of Rho1, which controls cell shape and septation in fission yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	EXP Inferred from Experiment more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	EXP Inferred from Experiment more info	PubMed
enables signaling adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of (1->3)-beta-D-glucan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell integrity MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic division septum assembly	EXP Inferred from Experiment more info	PubMed
involved_in positive regulation of primary cell septum biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell wall (1->3)-beta-D-glucan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of division septum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment or maintenance of cell polarity regulating cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fungal-type cell wall biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell cortex of growing cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of plasma membrane	NAS Non-traceable Author Statement more info
is_active_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in division septum	IDA Inferred from Direct Assay more info	PubMed
is_active_in growing cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in medial cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in protein aggregate center	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rho family GTPase Rho1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

4224071..4225824

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019919.3 → NP_594490.1 Rho family GTPase Rho1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_594490.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q09914

UniProtKB/TrEMBL

S6BDG7

Conserved Domains (2) summary

smart00174
Location:9 → 182

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd01870
Location:6 → 180

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC