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    Arhgdib Rho, GDP dissociation inhibitor beta [ Mus musculus (house mouse) ]

    Gene ID: 11857, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arhgdibprovided by MGI
    Official Full Name
    Rho, GDP dissociation inhibitor betaprovided by MGI
    Primary source
    MGI:MGI:101940
    See related
    Ensembl:ENSMUSG00000030220 AllianceGenome:MGI:101940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4; Gdid4; Ly-GDI
    Summary
    The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]
    Expression
    Biased expression in thymus adult (RPKM 157.4), spleen adult (RPKM 123.8) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgdib in Genome Data Viewer
    Location:
    6 G1; 6 66.72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136900653..136918895, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136923655..136941899, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene matrix Gla protein Neighboring gene endoplasmic reticulum protein 27 Neighboring gene STARR-seq mESC enhancer starr_17614 Neighboring gene STARR-positive B cell enhancer ABC_E3690 Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma Neighboring gene STARR-positive B cell enhancer ABC_E9680 Neighboring gene STARR-positive B cell enhancer mm9_chr6:136929021-136929322 Neighboring gene predicted gene, 30055

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Olofsson B. Cell Signal, 1999 Aug. PMID 10433515
    2. Activation of Rac1 by Rho-guanine nucleotide dissociation inhibitor-beta with defective isoprenyl-binding pocket. Ota T, et al. Cell Biol Int, 2007 Jan. PMID 17049467
    3. Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases. Yin L, et al. Mol Immunol, 1997 Apr. PMID 9307064
    4. GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor beta in melanoma B16 cells. Wang P, et al. Cancer Sci, 2011 Aug. PMID 21518140
    5. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. Jalink K, et al. J Cell Biol, 1994 Aug. PMID 8045941, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ly-GDI is a critical regulator of inflammatory injury after deposition of IgG immune complexes and that it negatively regulates the lung NF-kappaB activity.
      Title: Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis.
    2. these results indicate that RhoGDIbeta functions as a novel BMP4 signaling target that regulates adipogenesis and myogensis.
      Title: RhoGDIβ Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell Differentiation.
    3. Rictor regulates cell migration by suppressing RhoGDI2.
      Title: Rictor regulates cell migration by suppressing RhoGDI2.
    4. Raptor siRNA suppressed the effects of GM3 on Ly-GDI expression and Akt phosphorylation at Thr(308) , suggesting GM3 signals to be transduced to mTOR-Raptor and Akt-Thr(308) , leading to Ly-GDI stimulation
      Title: GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor beta in melanoma B16 cells.
    5. Rho GDIalpha and Rho GDIbeta play synergistic roles in lymphocyte migration and development by modulating activation cycle of the Rho proteins in a lymphoid organ-specific manner.
      Title: Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta.
    6. Impaired interaction of RhoGDIbeta with Rac1 isoprenyl groups possibly makes RhoGDIbeta function as a positive regulator for Rac1 during metastasis.
      Title: Activation of Rac1 by Rho-guanine nucleotide dissociation inhibitor-beta with defective isoprenyl-binding pocket.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Rho GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Rho GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables Rho GDP-dissociation inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of trophoblast cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of trophoblast cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GDP-dissociation inhibitor 2
    Names
    Rho, GDP dissociation inhibitor (GDI) beta
    rho GDI 2
    rho-GDI beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301301.2 → NP_001288230.1  rho GDP-dissociation inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_001288230.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
      Source sequence(s)
      AC125341
      Consensus CDS
      CCDS20661.1
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Related
      ENSMUSP00000107522.2, ENSMUST00000111891.4
      Conserved Domains (1) summary
      pfam02115
      Location:7 → 197
      Rho_GDI; RHO protein GDP dissociation inhibitor

    2. NM_001301303.2 → NP_001288232.1  rho GDP-dissociation inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_001288232.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
      Source sequence(s)
      AC125341
      Consensus CDS
      CCDS20661.1
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Conserved Domains (1) summary
      pfam02115
      Location:7 → 197
      Rho_GDI; RHO protein GDP dissociation inhibitor

    3. NM_001301305.2 → NP_001288234.1  rho GDP-dissociation inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_001288234.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
      Source sequence(s)
      AC125341
      Consensus CDS
      CCDS20661.1
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Related
      ENSMUSP00000107523.2, ENSMUST00000111892.8
      Conserved Domains (1) summary
      pfam02115
      Location:7 → 197
      Rho_GDI; RHO protein GDP dissociation inhibitor

    4. NM_001301308.2 → NP_001288237.1  rho GDP-dissociation inhibitor 2 isoform 2

      See identical proteins and their annotated locations for NP_001288237.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the coding region and uses a downstream start codon compared to variant 1. Variants 5, 6, and 17-20 all encode isoform 2, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q61599
      Conserved Domains (1) summary
      pfam02115
      Location:1 → 114
      Rho_GDI; RHO protein GDP dissociation inhibitor

    5. NM_001301309.2 → NP_001288238.1  rho GDP-dissociation inhibitor 2 isoform 2

      See identical proteins and their annotated locations for NP_001288238.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon in the coding region and uses a downstream start codon compared to variant 1. Variants 5, 6, and 17-20 all encode isoform 2, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q61599
      Conserved Domains (1) summary
      pfam02115
      Location:1 → 114
      Rho_GDI; RHO protein GDP dissociation inhibitor

    6. NM_001409490.1 → NP_001396419.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    7. NM_001409491.1 → NP_001396420.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    8. NM_001409492.1 → NP_001396421.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    9. NM_001409493.1 → NP_001396422.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    10. NM_001409494.1 → NP_001396423.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    11. NM_001409495.1 → NP_001396424.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    12. NM_001409497.1 → NP_001396426.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    13. NM_001409498.1 → NP_001396427.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    14. NM_001409499.1 → NP_001396428.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    15. NM_001409500.1 → NP_001396429.1  rho GDP-dissociation inhibitor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125341
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599

    16. NM_001409501.1 → NP_001396430.1  rho GDP-dissociation inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125341

    17. NM_001409502.1 → NP_001396431.1  rho GDP-dissociation inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125341

    18. NM_001409503.1 → NP_001396432.1  rho GDP-dissociation inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125341

    19. NM_001409504.1 → NP_001396433.1  rho GDP-dissociation inhibitor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125341

    20. NM_007486.6 → NP_031512.1  rho GDP-dissociation inhibitor 2 isoform 1

      See identical proteins and their annotated locations for NP_031512.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-4 and 7-16 all encode the same isoform (1).
      Source sequence(s)
      AC125341
      Consensus CDS
      CCDS20661.1
      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Related
      ENSMUSP00000032344.6, ENSMUST00000032344.12
      Conserved Domains (1) summary
      pfam02115
      Location:7 → 197
      Rho_GDI; RHO protein GDP dissociation inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      136900653..136918895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255118.2 → XP_030110978.1  rho GDP-dissociation inhibitor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TEB3, Q61599
      Conserved Domains (1) summary
      pfam02115
      Location:7 → 197
      Rho_GDI; RHO protein GDP dissociation inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61599.3 GenPept UniProtKB/Swiss-Prot:Q61599

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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