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    Klf9 Kruppel-like transcription factor 9 [ Mus musculus (house mouse) ]

    Gene ID: 16601, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Klf9provided by MGI
    Official Full Name
    Kruppel-like transcription factor 9provided by MGI
    Primary source
    MGI:MGI:1333856
    See related
    Ensembl:ENSMUSG00000033863 AllianceGenome:MGI:1333856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bteb1; BTEB-1; Gm9971; 2310051E17Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within embryo implantation; progesterone receptor signaling pathway; and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and skeleton. Orthologous to human KLF9 (KLF transcription factor 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 44.8), adrenal adult (RPKM 44.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klf9 in Genome Data Viewer
    Location:
    19 B; 19 17.9 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (23118590..23145493)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (23141226..23168129)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 3 Neighboring gene RIKEN cDNA C330002G04 gene Neighboring gene STARR-seq mESC enhancer starr_45752 Neighboring gene STARR-seq mESC enhancer starr_45755 Neighboring gene STARR-seq mESC enhancer starr_45757 Neighboring gene STARR-seq mESC enhancer starr_45759 Neighboring gene STARR-seq mESC enhancer starr_45760 Neighboring gene RIKEN cDNA 2410080I02 gene Neighboring gene STARR-seq mESC enhancer starr_45763 Neighboring gene STARR-positive B cell enhancer ABC_E4273 Neighboring gene STARR-seq mESC enhancer starr_45766 Neighboring gene STARR-seq mESC enhancer starr_45769 Neighboring gene STARR-seq mESC enhancer starr_45772 Neighboring gene microRNA 1192 Neighboring gene STARR-positive B cell enhancer mm9_chr19:23348377-23348678 Neighboring gene structural maintenance of chromosomes 5 Neighboring gene predicted gene, 33950 Neighboring gene predicted gene, 24263

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Klf9 is essential for cardiac mitochondrial homeostasis. Zhang L, et al. Nat Cardiovasc Res, 2024 Nov. PMID 39528719
    2. Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in mice. Velarde MC, et al. Biol Reprod, 2005 Sep. PMID 15917344
    3. High-Fat Diet Promotion of Endometriosis in an Immunocompetent Mouse Model is Associated With Altered Peripheral and Ectopic Lesion Redox and Inflammatory Status. Heard ME, et al. Endocrinology, 2016 Jul. PMID 27175969, Free PMC Article
    4. The Krüppel-like factor 9 cistrome in mouse hippocampal neurons reveals predominant transcriptional repression via proximal promoter binding. Knoedler JR, et al. BMC Genomics, 2017 Apr 13. PMID 28407733, Free PMC Article
    5. Targeting Kruppel-like Factor 9 in Excitatory Neurons Protects against Chronic Stress-Induced Impairments in Dendritic Spines and Fear Responses. Besnard A, et al. Cell Rep, 2018 Jun 12. PMID 29898391, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.
      Title: Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.
    2. Mechanism of KLF9 in airway inflammation in chronic obstructive pulmonary.
      Title: Mechanism of KLF9 in airway inflammation in chronic obstructive pulmonary.
    3. MicroRNA-30a-5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro.
      Title: MicroRNA‑30a‑5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro.
    4. Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
      Title: Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
    5. KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
      Title: KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
    6. KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARgamma/NRF2 Signalling.
      Title: KLF9 Aggravates Streptozotocin-Induced Diabetic Cardiomyopathy by Inhibiting PPARγ/NRF2 Signalling.
    7. Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression.
      Title: Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression.
    8. Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression.
      Title: Transcription factor Klf9 controls bile acid reabsorption and enterohepatic circulation in mice via promoting intestinal Asbt expression.
    9. microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis.
      Title: microRNA-26a shuttled by extracellular vesicles secreted from adipose-derived mesenchymal stem cells reduce neuronal damage through KLF9-mediated regulation of TRAF2/KLF2 axis.
    10. An Intact Kruppel-like factor 9 Gene Is Required for Acute Liver Period 1 mRNA Response to Restraint Stress.
      Title: An Intact Krüppel-like factor 9 Gene Is Required for Acute Liver Period 1 mRNA Response to Restraint Stress.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cortisol stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cortisol stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within embryo implantation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of keratinocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within progesterone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 9
    Names
    BTE-binding protein 1
    GC-box-binding protein 1
    Kruppel-like factor 9
    basic transcription element binding protein 1
    transcription factor BTEB1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010638.5 → NP_034768.2  Krueppel-like factor 9

      See identical proteins and their annotated locations for NP_034768.2

      Status: VALIDATED

      Source sequence(s)
      AC121973
      Consensus CDS
      CCDS29706.1
      UniProtKB/Swiss-Prot
      O35739
      UniProtKB/TrEMBL
      Q8CEC4
      Related
      ENSMUSP00000045639.2, ENSMUST00000036884.3
      Conserved Domains (2) summary
      COG5048
      Location:78 → 234
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:145 → 167
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      23118590..23145493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35739.1 GenPept UniProtKB/Swiss-Prot:O35739

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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