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    Coprs coordinator of PRMT5, differentiation stimulator [ Mus musculus (house mouse) ]

    Gene ID: 66423, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Coprsprovided by MGI
    Official Full Name
    coordinator of PRMT5, differentiation stimulatorprovided by MGI
    Primary source
    MGI:MGI:1913673
    See related
    Ensembl:ENSMUSG00000031458 AllianceGenome:MGI:1913673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Copr5; 1700029I03Rik; 2410022L05Rik
    Summary
    Predicted to enable histone binding activity. Involved in muscle organ development. Acts upstream of or within blastocyst hatching. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in early conceptus and secondary oocyte. Orthologous to human COPRS (coordinator of PRMT5 and differentiation stimulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 18.3), CNS E18 (RPKM 11.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coprs in Genome Data Viewer
    Location:
    8 A1.1; 8 6.41 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13934787..13940501, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13884787..13890352, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53400 Neighboring gene chromosome alignment maintaining phosphoprotein 1 Neighboring gene predicted gene, 24698 Neighboring gene interferon induced transmembrane protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:13907572-13907873 Neighboring gene STARR-seq mESC enhancer starr_20776 Neighboring gene F-box protein 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes. Paul C, et al. FEBS Open Bio, 2019 Jan. PMID 30652083, Free PMC Article
    2. The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion. Paul C, et al. Biol Open, 2015 Feb 13. PMID 25681392, Free PMC Article
    3. The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. Paul C, et al. Cell Death Differ, 2012 May. PMID 22193545, Free PMC Article
    4. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Jenne DE, et al. Genes Chromosomes Cancer, 2003 Jun. PMID 12696059
    5. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. Lacroix M, et al. EMBO Rep, 2008 May. PMID 18404153, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11316

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coordinator of PRMT5 and differentiation stimulator
    Names
    cooperator of PRMT5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359059.1 → NP_001345988.1  coordinator of PRMT5 and differentiation stimulator isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139186
      Conserved Domains (1) summary
      pfam15340
      Location:10 → 101
      COPR5; Cooperator of PRMT5 family

    2. NM_025556.3 → NP_079832.1  coordinator of PRMT5 and differentiation stimulator isoform 1

      See identical proteins and their annotated locations for NP_079832.1

      Status: VALIDATED

      Source sequence(s)
      AK008882, BY647791
      Consensus CDS
      CCDS40237.1
      UniProtKB/Swiss-Prot
      Q9CQ13
      Related
      ENSMUSP00000033839.8, ENSMUST00000033839.9
      Conserved Domains (1) summary
      pfam15340
      Location:24 → 173
      COPR5; Cooperator of PRMT5 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13934787..13940501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242070.4 → XP_011240372.1  coordinator of PRMT5 and differentiation stimulator isoform X1

      Conserved Domains (1) summary
      pfam15340
      Location:24 → 46
      COPR5; Cooperator of PRMT5 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ13.1 GenPept UniProtKB/Swiss-Prot:Q9CQ13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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