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    Zfp760 zinc finger protein 760 [ Mus musculus (house mouse) ]

    Gene ID: 240034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp760provided by MGI
    Official Full Name
    zinc finger protein 760provided by MGI
    Primary source
    MGI:MGI:2679257
    See related
    Ensembl:ENSMUSG00000067928 AllianceGenome:MGI:2679257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9430018I06
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.6), CNS E14 (RPKM 6.2) and 17 other tissues See more
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    Genomic context

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    See Zfp760 in Genome Data Viewer
    Location:
    17 A3.3; 17 11.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21926412..21944616)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21707430..21725636)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 983 Neighboring gene predicted gene, 53991 Neighboring gene STARR-positive B cell enhancer ABC_E1933 Neighboring gene predicted gene 10509 Neighboring gene STARR-seq mESC enhancer starr_42015 Neighboring gene zinc finger protein 229 Neighboring gene zinc finger protein 760 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC105247

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 760

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008501.3 → NP_001008501.2  zinc finger protein 760 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009755, MF597758
      Consensus CDS
      CCDS37465.1
      UniProtKB/TrEMBL
      E9QAF5
      Related
      ENSMUSP00000073038.7, ENSMUST00000073312.7
      Conserved Domains (5) summary
      COG5048
      Location:206 → 581
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:568 → 618
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 47
      KRAB; KRAB box
      pfam13465
      Location:614 → 639
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001410563.1 → NP_001397492.1  zinc finger protein 760 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009755, MF597758

    3. NM_001410564.1 → NP_001397493.1  zinc finger protein 760 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009755, MF597758
      UniProtKB/TrEMBL
      E9QAF5

    4. NM_001410565.1 → NP_001397494.1  zinc finger protein 760 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009755, MF597758
      UniProtKB/TrEMBL
      E9QAF5

    5. NM_001410566.1 → NP_001397495.1  zinc finger protein 760 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT009755, MF597758

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      21926412..21944616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249770.1 → XP_030105630.1  zinc finger protein 760 isoform X1

      Conserved Domains (5) summary
      COG5048
      Location:211 → 586
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:573 → 623
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:215 → 235
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
      pfam13465
      Location:619 → 644
      zf-H2C2_2; Zinc-finger double domain

    2. XM_030249771.1 → XP_030105631.1  zinc finger protein 760 isoform X2

      UniProtKB/TrEMBL
      E9QAF5
      Conserved Domains (5) summary
      COG5048
      Location:206 → 581
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:568 → 618
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:210 → 230
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:7 → 47
      KRAB; KRAB box
      pfam13465
      Location:614 → 639
      zf-H2C2_2; Zinc-finger double domain

    3. XM_030249773.1 → XP_030105633.1  zinc finger protein 760 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:165 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:527 → 577
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:169 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain

    4. XM_036160590.1 → XP_036016483.1  zinc finger protein 760 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:165 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:527 → 577
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:169 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain

    5. XM_030249772.1 → XP_030105632.1  zinc finger protein 760 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:165 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:527 → 577
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:169 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain

    6. XM_036160588.1 → XP_036016481.1  zinc finger protein 760 isoform X1

      Conserved Domains (5) summary
      COG5048
      Location:211 → 586
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:573 → 623
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:215 → 235
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
      pfam13465
      Location:619 → 644
      zf-H2C2_2; Zinc-finger double domain

    7. XM_036160591.1 → XP_036016484.1  zinc finger protein 760 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:165 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:527 → 577
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:169 → 189
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:573 → 598
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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