Ppard peroxisome proliferator activator receptor delta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppardprovided by MGI
Official Full Name: peroxisome proliferator activator receptor deltaprovided by MGI
Primary source: MGI:MGI:101884
See related: Ensembl:ENSMUSG00000002250 AllianceGenome:MGI:101884
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta
Summary: Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including negative regulation of myoblast differentiation; positive regulation of skeletal muscle tissue regeneration; and regulation of gene expression. Acts upstream of or within several processes, including keratinocyte migration; keratinocyte proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Used to study Huntington's disease and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in duodenum adult (RPKM 102.2), colon adult (RPKM 88.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 14.64 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (28451715..28520446)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28232754..28301469)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxisome Proliferator-Activated Receptor delta Suppresses the Cytotoxicity of CD8+ T Cells by Inhibiting RelA DNA-Binding Activity.
Title: Peroxisome Proliferator-Activated Receptor δ Suppresses the Cytotoxicity of CD8+ T Cells by Inhibiting RelA DNA-Binding Activity.
Inhibitory Regulation of FOXO1 in PPARdelta Expression Drives Mitochondrial Dysfunction and Insulin Resistance.
Title: Inhibitory Regulation of FOXO1 in PPARδ Expression Drives Mitochondrial Dysfunction and Insulin Resistance.
PPARalpha/delta dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells.
Title: PPARα/δ dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells.
PPARbeta/delta activation protects against hepatic ischaemia-reperfusion injury.
Title: PPARβ/δ activation protects against hepatic ischaemia-reperfusion injury.
High-Fat Diet Promotes Acute Promyelocytic Leukemia through PPARdelta-Enhanced Self-renewal of Preleukemic Progenitors.
Title: High-Fat Diet Promotes Acute Promyelocytic Leukemia through PPARδ-Enhanced Self-renewal of Preleukemic Progenitors.
Deletion of the PPARdelta gene exacerbates high-fat diet-induced nonalcoholic fatty liver disease in mice through the gut-liver axis.
Title: Deletion of the PPARδ gene exacerbates high-fat diet-induced nonalcoholic fatty liver disease in mice through the gut-liver axis.
Peroxisome proliferator-activated receptor delta improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching.
Title: Peroxisome proliferator-activated receptor δ improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching.
Transcription factors KLF15 and PPARdelta cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle.
Title: Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle.
PPARbeta mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation.
Title: PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation.
Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARdelta.
Title: Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ.

Submit: New GeneRIF Correction See all GeneRIFs (227)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Aus7 (e-PCR), detects polymorphism
- UniSTS:142110

MARC_45796-45797:1102976080:1 (e-PCR)
- UniSTS:471629

MARC_45800-45801:1102973340:2 (e-PCR)
- UniSTS:471631

Ppard (e-PCR), detects polymorphism
- UniSTS:527501

UniSTS:496033 (e-PCR)
- UniSTS:496033

Ppard (e-PCR), detects polymorphism
- UniSTS:496033

L28116 (e-PCR)
- UniSTS:124892

PMC117556P1 (e-PCR)
- UniSTS:270335

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme activator activity	TAS Traceable Author Statement more info	PubMed
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables linoleic acid binding	ISO Inferred from Sequence Orthology more info
enables linoleic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor activity	TAS Traceable Author Statement more info	PubMed
enables prostacyclin receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anagen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon ensheathment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in decidualization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo implantation	IDA Inferred from Direct Assay more info	PubMed
involved_in embryo implantation	TAS Traceable Author Statement more info	PubMed
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of fat cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid beta-oxidation	IEP Inferred from Expression Pattern more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epidermis development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fat cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fatty acid oxidation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteoglycan metabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteoglycan metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to vitamin A	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisome proliferator-activated receptor delta

Names: PPARdelta/beta; Peroxisome proliferator-activated receptor beta; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411509.1 → NP_001398438.1 peroxisome proliferator-activated receptor delta isoform 2

Status: VALIDATED

Source sequence(s)

AC126937, CT025652

UniProtKB/TrEMBL

A0A3B2W7W2
NM_001411510.1 → NP_001398439.1 peroxisome proliferator-activated receptor delta isoform 1

Status: VALIDATED

Source sequence(s)

CT025652

UniProtKB/Swiss-Prot

P35396, P37239

UniProtKB/TrEMBL

A0A3B2W7W2, Q546I3
NM_001411520.1 → NP_001398449.1 peroxisome proliferator-activated receptor delta isoform 3

Status: VALIDATED

Source sequence(s)

AC126937, CT025652
NM_001411521.1 → NP_001398450.1 peroxisome proliferator-activated receptor delta isoform 4

Status: VALIDATED

Source sequence(s)

AC126937, CT025652

UniProtKB/TrEMBL

A0A3B2W7W2

Related

ENSMUSP00000156879.2, ENSMUST00000232879.2
NM_001411522.1 → NP_001398451.1 peroxisome proliferator-activated receptor delta isoform 5

Status: VALIDATED

Source sequence(s)

AC126937, CT025652
NM_001411526.1 → NP_001398455.1 peroxisome proliferator-activated receptor delta isoform 1

Status: VALIDATED

Source sequence(s)

AC126937, CT025652

UniProtKB/Swiss-Prot

P35396, P37239

UniProtKB/TrEMBL

A0A3B2W7W2, Q546I3
NM_011145.4 → NP_035275.1 peroxisome proliferator-activated receptor delta isoform 1

See identical proteins and their annotated locations for NP_035275.1

Status: VALIDATED

Source sequence(s)

AC126937, CT025652

Consensus CDS

CCDS28575.1

UniProtKB/Swiss-Prot

P35396, P37239

UniProtKB/TrEMBL

A0A3B2W7W2, Q546I3

Related

ENSMUSP00000002320.9, ENSMUST00000002320.16

Conserved Domains (2) summary

cd06932
Location:172 → 439

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:72 → 155

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

28451715..28520446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160409.1 → XP_036016302.1 peroxisome proliferator-activated receptor delta isoform X2

UniProtKB/TrEMBL

A0A3B2W7W2

Conserved Domains (2) summary

cd06932
Location:134 → 401

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cl02596
Location:56 → 117

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers