Iqsec3 IQ motif and Sec7 domain 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iqsec3provided by MGI
Official Full Name: IQ motif and Sec7 domain 3provided by MGI
Primary source: MGI:MGI:2677208
See related: Ensembl:ENSMUSG00000040797 AllianceGenome:MGI:2677208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BRAG3; mKIAA1110; synarfGEF
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization; postsynapse organization; and regulation of small GTPase mediated signal transduction. Located in inhibitory synapse; postsynaptic density; and postsynaptic membrane. Is active in GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization of symmetric synapse. Is expressed in endocrine gland; male reproductive gland or organ; and nervous system. Orthologous to human IQSEC3 (IQ motif and Sec7 domain ArfGEF 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 20.3), cortex adult (RPKM 14.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 57.28 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (121349886..121450697, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (121372927..121473738, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
Title: Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus.
Title: Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus.
BRAG2 localized to postsynaptic processes at bipolar dyads, while BRAG3 localized to postsynaptic components at conventional synapses in mouse retina
Title: Distinct synaptic localization patterns of brefeldin A-resistant guanine nucleotide exchange factors BRAG2 and BRAG3 in the mouse retina.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization of symmetric synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: IQ motif and SEC7 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033354.4 → NP_001028526.1 IQ motif and SEC7 domain-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_001028526.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC115799, AC153982

Consensus CDS

CCDS20491.1

UniProtKB/Swiss-Prot

Q3TES0, Q3UHP8, Q80TJ8

Related

ENSMUSP00000038653.6, ENSMUST00000046373.8

Conserved Domains (2) summary

cd13318
Location:870 → 1000

PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain

pfam01369
Location:655 → 843

Sec7; Sec7 domain
NM_001289685.2 → NP_001276614.1 IQ motif and SEC7 domain-containing protein 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.

Source sequence(s)

AC115799, AC153982

Conserved Domains (2) summary

cd13318
Location:570 → 700

PH_IQSEC; IQ motif and SEC7 domain-containing protein family Pleckstrin homology domain

pfam01369
Location:355 → 543

Sec7; Sec7 domain
NM_001411678.1 → NP_001398607.1 IQ motif and SEC7 domain-containing protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC115799, AC153982
NM_001411679.1 → NP_001398608.1 IQ motif and SEC7 domain-containing protein 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC115799, AC153982

RNA

NR_110358.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 2 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC115799, AC153982

Related

ENSMUST00000129815.8
NR_177449.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC115799, AC153982
NR_177450.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC115799, AC153982

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

121349886..121450697 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506112.4 → XP_006506175.1 IQ motif and SEC7 domain-containing protein 3 isoform X2

Conserved Domains (4) summary

PRK12323
Location:122 → 287

PRK12323; DNA polymerase III subunit gamma/tau

cd14686
Location:32 → 63

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

pfam01369
Location:655 → 843

Sec7; Sec7 domain

pfam16453
Location:863 → 995

IQ_SEC7_PH; PH domain
XM_030255387.2 → XP_030111247.1 IQ motif and SEC7 domain-containing protein 3 isoform X5

UniProtKB/TrEMBL

Q3UHJ6

Conserved Domains (2) summary

pfam01369
Location:355 → 543

Sec7; Sec7 domain

pfam16453
Location:563 → 695

IQ_SEC7_PH; PH domain
XM_006506113.5 → XP_006506176.1 IQ motif and SEC7 domain-containing protein 3 isoform X3

Conserved Domains (4) summary

PRK12323
Location:122 → 287

PRK12323; DNA polymerase III subunit gamma/tau

cd14686
Location:32 → 63

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

pfam01369
Location:655 → 843

Sec7; Sec7 domain

pfam16453
Location:863 → 995

IQ_SEC7_PH; PH domain