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    Klf12 Kruppel-like transcription factor 12 [ Mus musculus (house mouse) ]

    Gene ID: 16597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klf12provided by MGI
    Official Full Name
    Kruppel-like transcription factor 12provided by MGI
    Primary source
    MGI:MGI:1333796
    See related
    Ensembl:ENSMUSG00000072294 AllianceGenome:MGI:1333796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP-2rep; 2700063E05Rik; B130052C06Rik; D530033K05Rik
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human KLF12 (KLF transcription factor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 4.9), CNS E14 (RPKM 4.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klf12 in Genome Data Viewer
    Location:
    14 E2.2- E2.3; 14 50.9 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (100103617..100719681, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (99866181..100285891, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37452 Neighboring gene predicted gene, 22970 Neighboring gene predicted pseudogene 5958 Neighboring gene RIKEN cDNA 2810416A17 gene Neighboring gene STARR-seq mESC enhancer starr_37454 Neighboring gene STARR-seq mESC enhancer starr_37455 Neighboring gene RIKEN cDNA 4930517O19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr14:100610424-100610725 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37462 Neighboring gene predicted gene, 41231 Neighboring gene STARR-seq mESC enhancer starr_37463 Neighboring gene STARR-positive B cell enhancer mm9_chr14:100858327-100858628 Neighboring gene STARR-positive B cell enhancer mm9_chr14:100860836-100861137 Neighboring gene predicted gene, 34199 Neighboring gene predicted gene, 26367 Neighboring gene predicted gene, 24345 Neighboring gene ribosomal protein L10A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KLF12 Regulates Mouse NK Cell Proliferation. Lam VC, et al. J Immunol, 2019 Aug 15. PMID 31300511, Free PMC Article
    2. Regulation of KLF12 by microRNA-20b and microRNA-106a in cystogenesis. Shin Y, et al. FASEB J, 2018 Jul. PMID 29475398
    3. Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12). Roth C, et al. Genomics, 2000 Feb 1. PMID 10704285
    4. KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer. Pan X, et al. Mol Oncol, 2023 Dec. PMID 37606530, Free PMC Article
    5. A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in mice†. Liu Y, et al. Biol Reprod, 2021 Oct 11. PMID 34104947

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
      Title: KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
    2. A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in micedagger.
      Title: A high level of KLF12 causes folic acid-resistant neural tube defects by activating the Shh signaling pathway in mice†.
    3. we found that KLF12 regulates mouse NK cell proliferation
      Title: KLF12 Regulates Mouse NK Cell Proliferation.
    4. Klf12 expression is down-regulated in kidney tissues of Pkd2f/f mice. miR-20b-5p and miR-106a-5p directly target Klf12 mRNA by binding to the 3'-UTR of Klf12.
      Title: Regulation of KLF12 by microRNA-20b and microRNA-106a in cystogenesis.
    5. KLF12 is involved in the maturation processes of collecting ducts after birth, and UT-A1 is a target gene of KLF12.
      Title: Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 12
    Names
    Kruppel-like factor 12
    transcriptional repressor AP-2rep

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411709.1 → NP_001398638.1  Krueppel-like factor 12

      Status: VALIDATED

      Source sequence(s)
      AC113486, AC116856, AC117638, AC125446
      UniProtKB/Swiss-Prot
      O35738, Q6NWV9
      Related
      ENSMUSP00000153901.2, ENSMUST00000228216.2

    2. NM_010636.4 → NP_034766.2  Krueppel-like factor 12

      See identical proteins and their annotated locations for NP_034766.2

      Status: VALIDATED

      Source sequence(s)
      AC113486, AC116856, AC117638, AC125446
      Consensus CDS
      CCDS36998.1
      UniProtKB/Swiss-Prot
      O35738, Q6NWV9
      Conserved Domains (4) summary
      COG5048
      Location:225 → 401
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:363 → 388
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:27 → 224
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      100103617..100719681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158486.1 → XP_036014379.1  Krueppel-like factor 12 isoform X1

      UniProtKB/Swiss-Prot
      O35738, Q6NWV9
      Related
      ENSMUSP00000094844.5, ENSMUST00000097079.5
      Conserved Domains (4) summary
      COG5048
      Location:225 → 401
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:363 → 388
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:27 → 224
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    2. XM_011244971.4 → XP_011243273.1  Krueppel-like factor 12 isoform X3

      See identical proteins and their annotated locations for XP_011243273.1

      Conserved Domains (3) summary
      COG5048
      Location:206 → 382
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 322
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:344 → 369
      zf-H2C2_2; Zinc-finger double domain

    3. XM_036158490.1 → XP_036014383.1  Krueppel-like factor 12 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    4. XM_030247664.2 → XP_030103524.1  Krueppel-like factor 12 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    5. XM_036158488.1 → XP_036014381.1  Krueppel-like factor 12 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    6. XM_036158485.1 → XP_036014378.1  Krueppel-like factor 12 isoform X1

      UniProtKB/Swiss-Prot
      O35738, Q6NWV9
      Conserved Domains (4) summary
      COG5048
      Location:225 → 401
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:363 → 388
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:27 → 224
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    7. XM_006518625.5 → XP_006518688.1  Krueppel-like factor 12 isoform X3

      See identical proteins and their annotated locations for XP_006518688.1

      Conserved Domains (3) summary
      COG5048
      Location:206 → 382
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 322
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:344 → 369
      zf-H2C2_2; Zinc-finger double domain

    8. XM_017315889.3 → XP_017171378.1  Krueppel-like factor 12 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    9. XM_036158489.1 → XP_036014382.1  Krueppel-like factor 12 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    10. XM_030247662.2 → XP_030103522.1  Krueppel-like factor 12 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    11. XM_036158487.1 → XP_036014380.1  Krueppel-like factor 12 isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:175 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:313 → 338
      zf-H2C2_2; Zinc-finger double domain
      cl40450
      Location:1 → 174
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    12. XM_011244970.4 → XP_011243272.1  Krueppel-like factor 12 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:218 → 394
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:312 → 334
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:356 → 381
      zf-H2C2_2; Zinc-finger double domain

    13. XM_011244968.4 → XP_011243270.1  Krueppel-like factor 12 isoform X1

      See identical proteins and their annotated locations for XP_011243270.1

      UniProtKB/Swiss-Prot
      O35738, Q6NWV9
      Conserved Domains (4) summary
      COG5048
      Location:225 → 401
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:319 → 341
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:363 → 388
      zf-H2C2_2; Zinc-finger double domain
      cd21441
      Location:27 → 224
      KLF12_N; N-terminal domain of Kruppel-like factor 12

    14. XM_036158491.1 → XP_036014384.1  Krueppel-like factor 12 isoform X5

      Conserved Domains (1) summary
      cl40450
      Location:27 → 224
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins

    15. XM_036158492.1 → XP_036014385.1  Krueppel-like factor 12 isoform X6

      Conserved Domains (1) summary
      cl40450
      Location:27 → 224
      KLF8_12_N; N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35738.2 GenPept UniProtKB/Swiss-Prot:O35738

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