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    Gfus GDP-L-fucose synthase [ Mus musculus (house mouse) ]

    Gene ID: 22122, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gfusprovided by MGI
    Official Full Name
    GDP-L-fucose synthaseprovided by MGI
    Primary source
    MGI:MGI:98857
    See related
    Ensembl:ENSMUSG00000022570 AllianceGenome:MGI:98857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FX; Tsta3; Tstap35b
    Summary
    Enables GDP-L-fucose synthase activity and isomerase activity. Involved in 'de novo' GDP-L-fucose biosynthetic process. Acts upstream of or within T cell mediated cytotoxicity. Is active in cytosol. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 74.6), large intestine adult (RPKM 59.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gfus in Genome Data Viewer
    Location:
    15 D3; 15 35.1 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75796532..75801613, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75924669..75929821, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene zinc finger protein 623 Neighboring gene STARR-seq mESC enhancer starr_39034 Neighboring gene predicted gene, 53898

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Strain-specific modification of lethality in fucose-deficient mice. Becker DJ, et al. Mamm Genome, 2003 Feb. PMID 12584608
    2. Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. Wang Y, et al. Gastroenterology, 2017 Jan. PMID 27639802, Free PMC Article
    3. Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus. Smith PL, et al. J Cell Biol, 2002 Aug 19. PMID 12186857, Free PMC Article
    4. An Alkynyl-Fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose-Synthesizing Enzyme FX, TSTA3. Kizuka Y, et al. Cell Chem Biol, 2017 Dec 21. PMID 29033318
    5. Structure of the gene of tum- transplantation antigen P35B: presence of a point mutation in the antigenic allele. Szikora JP, et al. EMBO J, 1990 Apr. PMID 2108859, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fucosylation-modified Notch receptor may represent a novel extrinsic regulator for hematopoietic stem cells (HSC) engraftment and HSC niche maintenance.
      Title: Fucose-deficient hematopoietic stem cells have decreased self-renewal and aberrant marrow niche occupancy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113801

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-L-fucose synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-L-fucose synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-L-fucose synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GDP-L-fucose synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP-mannose 3,5-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' GDP-L-fucose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 'de novo' GDP-L-fucose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP-mannose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDP-L-fucose synthase
    Names
    GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
    GDP-L-fucose synthetase
    GDP-fucose synthase
    protein FX
    red cell NADP(H)-binding protein
    tissue specific transplantation antigen P35B
    transplantation antigen P35B
    tum-P35B antigen
    NP_001343934.1
    NP_001398744.1
    NP_001398745.1
    NP_112478.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357005.2 → NP_001343934.1  GDP-L-fucose synthase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS27555.1
      UniProtKB/Swiss-Prot
      P23591
      UniProtKB/TrEMBL
      A0A2R8VHD0, Q5HZI6
      Related
      ENSMUSP00000155139.2, ENSMUST00000229641.2
      Conserved Domains (1) summary
      cd05239
      Location:9 → 312
      GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

    2. NM_001411815.1 → NP_001398744.1  GDP-L-fucose synthase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116520
      UniProtKB/TrEMBL
      A0A2R8VI39, A0A2R8W6P6

    3. NM_001411816.1 → NP_001398745.1  GDP-L-fucose synthase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC116520
      UniProtKB/TrEMBL
      A0A2R8VI39, A0A2R8W6P6
      Related
      ENSMUSP00000155711.2, ENSMUST00000229951.2

    4. NM_031201.2 → NP_112478.1  GDP-L-fucose synthase isoform 1

      See identical proteins and their annotated locations for NP_112478.1

      Status: VALIDATED

      Source sequence(s)
      AC116520
      Consensus CDS
      CCDS27555.1
      UniProtKB/Swiss-Prot
      P23591
      UniProtKB/TrEMBL
      A0A2R8VHD0, Q5HZI6
      Related
      ENSMUSP00000023231.6, ENSMUST00000023231.7
      Conserved Domains (1) summary
      cd05239
      Location:9 → 312
      GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs

    RNA

    1. NR_177931.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116520
      Related
      ENSMUST00000229085.2

    2. NR_177932.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116520

    3. NR_177933.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116520

    4. NR_177934.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116520

    5. NR_177935.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116520

    6. NR_177936.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116520

    7. NR_177937.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116520

    8. NR_177938.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116520
      Related
      ENSMUST00000230364.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75796532..75801613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23591.3 GenPept UniProtKB/Swiss-Prot:P23591

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