Ptgis prostaglandin I2 (prostacyclin) synthase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgisprovided by MGI
Official Full Name: prostaglandin I2 (prostacyclin) synthaseprovided by MGI
Primary source: MGI:MGI:1097156
See related: Ensembl:ENSMUSG00000017969 AllianceGenome:MGI:1097156
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp8; Pgis; Cyp8a1
Summary: Predicted to enable heme binding activity and prostaglandin-I synthase activity. Acts upstream of or within decidualization and embryo implantation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; ear; early embryo; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 56.6), ovary adult (RPKM 52.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 87.22 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (167045114..167095069, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (167203194..167252150, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA2 Prostanoids/TP Axis.
Title: Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA(2) Prostanoids/TP Axis.
Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer.
Title: Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer.
Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Title: Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Prostacyclin synthase and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.
Title: Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
Taken together, our in vitro and in vivo findings show that prostacyclin is secreted from neovessels formed as a result of CNS inflammation
Title: Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin.
Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner.
Title: Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner.
COX-1 contributes to the enhanced formation of both PGI(2) and TXA(2) in atherosclerosis, and to the development of the disease
Title: Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse.
The results establish a role for the IP receptor in protecting pyramidal hippocampal neurons after this global ischemic model and suggest that IP receptor agonists could be developed to prevent delayed pyramidal neuronal cell death.
Title: Prostacyclin receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery occlusion in mouse.
PGIS/ IP transgenic animals with lung-specific PPARgamma overexpression also developed fewer lung tumors.
Title: Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma.
identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4(+) Th2 cells into the inflammatory site
Title: Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptgis (e-PCR), detects polymorphism
- UniSTS:463024

AW529446 (e-PCR)
- UniSTS:261087

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables prostaglandin-I synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-I synthase activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin-I synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-6	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within decidualization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryo implantation	IDA Inferred from Direct Assay more info	PubMed
involved_in icosanoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in icosanoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prostacyclin synthase

Names: hydroperoxy icosatetraenoate dehydratase

NP_001407681.1

EC 4.2.1.152

EC 5.3.99.4

NP_001407682.1

EC 4.2.1.152

EC 5.3.99.4

NP_001407683.1

EC 4.2.1.152

EC 5.3.99.4

NP_001407684.1

EC 4.2.1.152

EC 5.3.99.4

NP_001407685.1

EC 4.2.1.152

EC 5.3.99.4

NP_032994.1

EC 4.2.1.152

EC 5.3.99.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420752.1 → NP_001407681.1 prostacyclin synthase isoform b

Status: VALIDATED

Source sequence(s)

AL591854
NM_001420753.1 → NP_001407682.1 prostacyclin synthase isoform c

Status: VALIDATED

Source sequence(s)

AL591854
NM_001420754.1 → NP_001407683.1 prostacyclin synthase isoform c

Status: VALIDATED

Source sequence(s)

AL591854
NM_001420755.1 → NP_001407684.1 prostacyclin synthase isoform c

Status: VALIDATED

Source sequence(s)

AL591854
NM_001420756.1 → NP_001407685.1 prostacyclin synthase isoform d

Status: VALIDATED

Source sequence(s)

AL591854
NM_008968.5 → NP_032994.1 prostacyclin synthase isoform a

See identical proteins and their annotated locations for NP_032994.1

Status: VALIDATED

Source sequence(s)

AL591854

Consensus CDS

CCDS17097.1

UniProtKB/Swiss-Prot

O35074

UniProtKB/TrEMBL

Q8BXC0

Related

ENSMUSP00000018113.8, ENSMUST00000018113.8

Conserved Domains (1) summary

cl12078
Location:28 → 490

p450; Cytochrome P450