U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Pglyrp4 peptidoglycan recognition protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310611, updated on 4-Jan-2025

    Summary

    Official Symbol
    Pglyrp4provided by RGD
    Official Full Name
    peptidoglycan recognition protein 4provided by RGD
    Primary source
    RGD:1308520
    See related
    EnsemblRapid:ENSRNOG00000021798 AllianceGenome:RGD:1308520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptidoglycan binding activity; peptidoglycan immune receptor activity; and protein heterodimerization activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and detection of bacterium. Predicted to act upstream of or within biological process involved in interaction with host; negative regulation of natural killer cell differentiation involved in immune response; and negative regulation of type II interferon production. Predicted to be part of protein-containing complex. Orthologous to human PGLYRP4 (peptidoglycan recognition protein 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 6.0), Spleen (RPKM 0.8) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pglyrp4 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178500238..178669328)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (176202654..176322859)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (190125655..190204230)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A8 Neighboring gene S100 calcium binding protein A9 Neighboring gene nudix hydrolase 5, pseudogene 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene phosphate cytidylyltransferase 1A, choline, pseudogene 4 Neighboring gene S100 calcium binding protein A7 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidoglycan immune receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidoglycan recognition protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191708.1NP_001178637.1  peptidoglycan recognition protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4AEA3
      Related
      ENSRNOP00000110378.1, ENSRNOT00000158298.1
      Conserved Domains (1) summary
      smart00701
      Location:58192
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
    2. NM_001412554.1NP_001399483.1  peptidoglycan recognition protein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4AEA3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      178500238..178669328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102299.2XP_038958227.1  peptidoglycan recognition protein 4 isoform X4

      UniProtKB/TrEMBL
      D4AEA3
      Conserved Domains (1) summary
      smart00701
      Location:67201
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
    2. XM_063281821.1XP_063137891.1  peptidoglycan recognition protein 4 isoform X2

    3. XM_063281822.1XP_063137892.1  peptidoglycan recognition protein 4 isoform X3

    4. XM_063281820.1XP_063137890.1  peptidoglycan recognition protein 4 isoform X1

      Related
      ENSRNOP00000029961.6, ENSRNOT00000029771.7

    RNA

    1. XR_010063605.1 RNA Sequence

    2. XR_010063606.1 RNA Sequence

    3. XR_005500289.2 RNA Sequence