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    Tulp4 TUB like protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tulp4provided by RGD
    Official Full Name
    TUB like protein 4provided by RGD
    Primary source
    RGD:1564487
    See related
    EnsemblRapid:ENSRNOG00000018012 AllianceGenome:RGD:1564487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564487
    Summary
    Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm. Orthologous to human TULP4 (TUB like protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 153.6), Brain (RPKM 114.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tulp4 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49082492..49218262)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (46682416..46813167)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47002928..47128114)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099116 Neighboring gene serine active site containing 1 Neighboring gene uncharacterized LOC102551377 Neighboring gene general transcription factor IIH subunit 5 Neighboring gene transfer RNA proline (anticodon AGG) 33 Neighboring gene uncharacterized LOC134482652 Neighboring gene transmembrane protein 181 Neighboring gene dynein light chain Tctex-type 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily. Li QZ, et al. Gene, 2001 Aug 8. PMID 11595174
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubby-related protein 4
    Names
    tubby like protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109137.2 → NP_001102607.1  tubby-related protein 4

      See identical proteins and their annotated locations for NP_001102607.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6KP05, D3ZFM2
      Related
      ENSRNOP00000024412.3, ENSRNOT00000024412.7
      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      pfam01167
      Location:1469 → 1539
      Tub; Tub family
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl02567
      Location:78 → 218
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      49082492..49218262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270684.1 → XP_063126754.1  tubby-related protein 4 isoform X1

      UniProtKB/TrEMBL
      A6KP05, D3ZFM2

    2. XM_008758737.4 → XP_008756959.1  tubby-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_008756959.1

      UniProtKB/TrEMBL
      A6KP05, D3ZFM2
      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      pfam01167
      Location:1469 → 1539
      Tub; Tub family
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl02567
      Location:78 → 218
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006227887.5 → XP_006227949.1  tubby-related protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006227949.1

      UniProtKB/TrEMBL
      A6KP05, D3ZFM2
      Conserved Domains (5) summary
      COG2319
      Location:67 → 217
      WD40; WD40 repeat [General function prediction only]
      pfam01167
      Location:1469 → 1539
      Tub; Tub family
      sd00039
      Location:85 → 123
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:373 → 408
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl02567
      Location:78 → 218
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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