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    Cass4 Cas scaffolding protein family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 320664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cass4provided by MGI
    Official Full Name
    Cas scaffolding protein family member 4provided by MGI
    Primary source
    MGI:MGI:2444482
    See related
    Ensembl:ENSMUSG00000074570 AllianceGenome:MGI:2444482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F730031O20Rik
    Summary
    Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in focal adhesion. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Orthologous to human CASS4 (Cas scaffold protein family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 2.2), thymus adult (RPKM 1.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cass4 in Genome Data Viewer
    Location:
    2 H3; 2 94.85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172234998..172275672)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172393644..172433752)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 210, member B Neighboring gene aurora kinase A Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1 Neighboring gene STARR-seq mESC enhancer starr_06572 Neighboring gene STARR-positive B cell enhancer ABC_E823 Neighboring gene uncharacterized LOC118568483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172259262-172259485 Neighboring gene STARR-positive B cell enhancer ABC_E3425 Neighboring gene replication termination factor 2 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7 Neighboring gene family with sequence similarity 209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects. Lu W, et al. PLoS Genet, 2007 May 25. PMID 17530927, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • RP23-228E2.3

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cas scaffolding protein family member 4
    Names
    likely orthologue of H. sapiens chromosome 20 open reading frame 32 (C20orf32)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080820.4 → NP_001074289.1  cas scaffolding protein family member 4 isoform 2

      See identical proteins and their annotated locations for NP_001074289.1

      Status: VALIDATED

      Source sequence(s)
      AL833787
      Consensus CDS
      CCDS38347.1
      UniProtKB/Swiss-Prot
      A1L397, Q08EC3, Q08EC4, Q3TCH3
      Related
      ENSMUSP00000104764.3, ENSMUST00000109136.3
      Conserved Domains (3) summary
      cd12000
      Location:14 → 70
      SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
      pfam08824
      Location:433 → 588
      Serine_rich; Serine rich protein interaction domain
      cl13463
      Location:683 → 804
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    2. NM_001276422.3 → NP_001263351.1  cas scaffolding protein family member 4 isoform 3

      See identical proteins and their annotated locations for NP_001263351.1

      Status: VALIDATED

      Source sequence(s)
      AL833787
      Consensus CDS
      CCDS89589.1
      UniProtKB/Swiss-Prot
      Q08EC4
      Related
      ENSMUSP00000154073.2, ENSMUST00000228775.2
      Conserved Domains (3) summary
      cd12000
      Location:14 → 70
      SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
      pfam08824
      Location:435 → 590
      Serine_rich; Serine rich protein interaction domain
      cl13463
      Location:659 → 780
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    3. NM_001276423.3 → NP_001263352.1  cas scaffolding protein family member 4 isoform 4

      See identical proteins and their annotated locations for NP_001263352.1

      Status: VALIDATED

      Source sequence(s)
      AL833787
      Consensus CDS
      CCDS71205.1
      UniProtKB/TrEMBL
      A0A0R4J199
      Related
      ENSMUSP00000099362.3, ENSMUST00000103073.9
      Conserved Domains (3) summary
      cd12000
      Location:14 → 70
      SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
      pfam08824
      Location:433 → 588
      Serine_rich; Serine rich protein interaction domain
      cl13463
      Location:657 → 778
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    4. NM_001379465.2 → NP_001366394.1  cas scaffolding protein family member 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL833787
      Conserved Domains (3) summary
      cd12000
      Location:14 → 70
      SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
      pfam08824
      Location:435 → 590
      Serine_rich; Serine rich protein interaction domain
      cl13463
      Location:685 → 806
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    5. NM_001379466.2 → NP_001366395.1  cas scaffolding protein family member 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL833787
      Conserved Domains (3) summary
      cd12000
      Location:14 → 70
      SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
      pfam08824
      Location:435 → 590
      Serine_rich; Serine rich protein interaction domain
      cl13463
      Location:684 → 805
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    6. NM_001379467.2 → NP_001366396.1  cas scaffolding protein family member 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL833787
      Conserved Domains (3) summary
      cd12000
      Location:14 → 70
      SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
      pfam08824
      Location:433 → 588
      Serine_rich; Serine rich protein interaction domain
      cl13463
      Location:682 → 803
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      172234998..172275672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162308.1 → XP_036018201.1  cas scaffolding protein family member 4 isoform X1

      Conserved Domains (3) summary
      cd12000
      Location:5 → 61
      SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
      pfam08824
      Location:426 → 581
      Serine_rich; Serine rich protein interaction domain
      cl13463
      Location:676 → 797
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    2. XM_036162309.1 → XP_036018202.1  cas scaffolding protein family member 4 isoform X2

      Conserved Domains (4) summary
      cd12000
      Location:14 → 70
      SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
      PHA03378
      Location:60 → 294
      PHA03378; EBNA-3B; Provisional
      pfam08824
      Location:408 → 563
      Serine_rich; Serine rich protein interaction domain
      cl13463
      Location:658 → 779
      FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033538.2: Suppressed sequence

      Description
      NM_001033538.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08EC4.1 GenPept UniProtKB/Swiss-Prot:Q08EC4

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