IL20RB interleukin 20 receptor subunit beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL20RBprovided by HGNC
Official Full Name: interleukin 20 receptor subunit betaprovided by HGNC
Primary source: HGNC:HGNC:6004
See related: Ensembl:ENSG00000174564 MIM:605621; AllianceGenome:HGNC:6004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DIRS1; FNDC6; IL-20R2
Summary: IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
Expression: Biased expression in skin (RPKM 54.3) and esophagus (RPKM 20.8) See more
Orthologs: mouse all
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Genomic context

Location:: 3q22.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (136957983..137011085)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (139698644..139751732)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (136676825..136729927)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma.
Title: Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma.
Trabecular meshwork cells express IL-20 receptors; Mutation of the T104 residue in IL-20R2 leads to a reduction in STAT3 phosphorylation as well as decreased matrix metalloproteinase activity
Title: Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma.
The crystal structure of the IL-20/IL-20R1/IL-20R2 complex reveals how type I and II complexes discriminate cognate from noncognate ligands
Title: Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.
crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%
Title: Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.
Complete mda-7/IL-24 receptors (IL-22R1/IL-20R2 and IL-20R1/IL-20R2) are seldom expressed in liver cancer cell lines.
Title: Expression pattern of mda-7/IL-24 receptors in liver cancer cell lines.
The hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis and single nucleotide polymorphisms (SNPs) in the IL20RA and IL20RB genes in psoriasis patients were investigated.
Title: Association analysis of IL20RA and IL20RB genes in psoriasis.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association analysis of IL20RA and IL20RB genes in psoriasis.
forms stable complex with interleukin-19 and interleukin-20 [IL-20R1][IL-20R2]
Title: Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of co-occurring anxiety in major depression. EBI GWAS Catalog EBI GWAS CatalogPubMed
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-AA024977 (e-PCR)
- UniSTS:15460

RH103384 (e-PCR)
- UniSTS:97710

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-20 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CD8-positive, alpha-beta T cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
involved_in immune response-inhibiting signal transduction	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-2 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type IV hypersensitivity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-20 receptor subunit beta

Names: IL-20 receptor subunit beta; IL-20R-beta; IL-20RB; fibronectin type III domain containing 6; interleukin 20 receptor beta subunit; interleukin-20 receptor II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144717.4 → NP_653318.2 interleukin-20 receptor subunit beta precursor

See identical proteins and their annotated locations for NP_653318.2

Status: VALIDATED

Source sequence(s)

AY358305, BC063696

Consensus CDS

CCDS3093.1

UniProtKB/Swiss-Prot

B4DL40, Q6P438, Q6UXL0, Q8IYY5, Q8TAJ7

Related

ENSP00000328133.4, ENST00000329582.9

Conserved Domains (2) summary

pfam01108
Location:30 → 124

Tissue_fac; Tissue factor

cl21522
Location:136 → 225

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

136957983..137011085

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011512911.3 → XP_011511213.1 interleukin-20 receptor subunit beta isoform X2

See identical proteins and their annotated locations for XP_011511213.1

Conserved Domains (1) summary

cl21522
Location:1 → 77

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_011512910.4 → XP_011511212.1 interleukin-20 receptor subunit beta isoform X1

Conserved Domains (2) summary

pfam01108
Location:35 → 129

Tissue_fac; Tissue factor

cl21522
Location:141 → 230

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_017006632.1 → XP_016862121.1 interleukin-20 receptor subunit beta isoform X2

Conserved Domains (1) summary

cl21522
Location:1 → 77

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006713665.5 → XP_006713728.1 interleukin-20 receptor subunit beta isoform X2

See identical proteins and their annotated locations for XP_006713728.1

Conserved Domains (1) summary

cl21522
Location:1 → 77

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...