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    AOX3P-AOX2P AOX3P-AOX2P readthrough, transcribed pseudogene [ Homo sapiens (human) ]

    Gene ID: 107161151, updated on 10-Dec-2024

    Summary

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    Official Symbol
    AOX3P-AOX2Pprovided by HGNC
    Official Full Name
    AOX3P-AOX2P readthrough, transcribed pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:53766
    See related
    AllianceGenome:HGNC:53766
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AOX3/AOX3L1
    Summary
    This locus represents naturally-occurring readthrough transcription between two unprocessed unitary pseudogenes, AOX3P (aldehyde oxidase 3, pseudogene) and AOX2P (aldehyde oxidase 2 pseudogene). The individual pseudogene loci are not curated as transcribed regions. Readthrough transcripts contains disrupted open reading frames, relative to functional homologs, and likely do not encode functional proteins. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in bone marrow (RPKM 1.1), testis (RPKM 0.1) and 2 other tissues See more
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    Genomic context

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    See AOX3P-AOX2P in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (200695723..200794915)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201179102..201278339)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201560446..201659638)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene shugoshin 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:201473343-201474542 Neighboring gene aldehyde oxidase 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:201513174-201514373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16961 Neighboring gene aldehyde oxidase 3, pseudogene Neighboring gene long intergenic non-protein coding RNA 1792 Neighboring gene aldehyde oxidase 2, pseudogene Neighboring gene AOX3P-AOX2P intron CAGE-defined mid-level expression enhancer Neighboring gene RNA, U1 small nuclear 133, pseudogene Neighboring gene BZW1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12227 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:201676955-201677470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:201677471-201677986 Neighboring gene RNA, U6 small nuclear 31, pseudogene Neighboring gene basic leucine zipper and W2 domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Kurosaki M, et al. Cell Mol Life Sci, 2013 May. PMID 23263164, Free PMC Article
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_135011.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) represents the longer transcript.
      Source sequence(s)
      AC007163, AY245868, DB150752, DB344122, DV080673, JX431286

    2. NR_135012.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) lacks an alternate exon in the 5' region, resulting in a shorter transcript than variant B.
      Source sequence(s)
      AC007163, AY245868, DB150752, DB344122, DV080673, JX431285

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      200695723..200794915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      201179102..201278339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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