Airn antisense Igf2r RNA [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Airnprovided by MGI
Official Full Name: antisense Igf2r RNAprovided by MGI
Primary source: MGI:MGI:1353471
See related: Ensembl:ENSMUSG00000078247 AllianceGenome:MGI:1353471
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Air; IGF2RAS; D17Ertd663e; 2810051F02Rik; 2810434M15Rik; B930018I07Rik
Summary: This gene is a paternally expressed imprinted gene. Alternatively spliced transcript variants have been produced from this gene and they are all long non-coding RNAs. These variants share the same 5' exon, and their 3' exons are divergent. The 5' exon overlaps the intron 2 of the Igf2r gene on the opposite strand. The Igf2r intron 2 contains a CpG island, which is a promoter and drives the expression of this gene. This gene is responsible for silencing Igf2r, and the flanking Slc22a2 and Slc22a3 genes in the imprinted gene cluster. It regulates transcription of these genes through epigenetic modifications. [provided by RefSeq, Jan 2013]
Expression: Broad expression in limb E14.5 (RPKM 7.3), bladder adult (RPKM 3.7) and 20 other tissues See more
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Genomic context

Location:: 17 8.66 cM; 17 A1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (12960198..13078771)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (12741311..12859884)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn.
Title: Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn.
LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-kappaB signaling pathway.
Title: LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway.
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Title: LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway.
Title: LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway.
Downregulation of long non-coding RNA AIRN promotes mitophagy in alcoholic fatty hepatocytes by promoting ubiquitination of mTOR.
Title: Downregulation of long non-coding RNA AIRN promotes mitophagy in alcoholic fatty hepatocytes by promoting ubiquitination of mTOR.
Long noncoding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2.
Title: Long noncoding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2.
Chromatin environments surrounding Xist, Airn, and Kcnq1ot1 suggest common mechanisms of PRC engagement and spreading. Our data indicate that lncRNA potency can be tightly linked to lncRNA abundance and that within lncRNA-targeted domains, PRCs are recruited to CGIs via lncRNA-independent mechanisms.
Title: lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA.
Study showed that chromosome interactions between the Airn gene body and the Slc22a3 promoter are enriched on the maternal allele because Airn expression represses these interactions on the paternal allele. These interactions are not required to upregulate Slc22a3 expression on the maternal allele, indicating that they are not essential promoter- enhancer interactions; they may serve to place both loci in close promixity.
Title: The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes.
In cardiomyocytes, silencing of Airn via siRNAs augmented cell death, vulnerability to cellular stress, and reduced cell migration. It also caused less binding of Igf2bp2 to other mRNAs and reduced translation of Igf2bp2 protein. Airn's binding partners were Igf2bp2 and Rpa1.
Title: Airn Regulates Igf2bp2 Translation in Cardiomyocytes.
Airn expression is both necessary and sufficient to silence Igf2r throughout embryonic stem cell differentiation.
Title: Imprinted Igf2r silencing depends on continuous Airn lncRNA expression and is not restricted to a developmental window.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237576

AU015441 (e-PCR)
- UniSTS:167223

BB276039 (e-PCR)
- UniSTS:209271

RH136060 (e-PCR)
- UniSTS:210055

Airn (e-PCR), detects polymorphism
- UniSTS:532130

Airn (e-PCR), detects polymorphism
- UniSTS:532131

PMC136958P1 (e-PCR)
- UniSTS:270810

AI597500 (e-PCR)
- UniSTS:180960

AW049873 (e-PCR)
- UniSTS:180961

D17Jcs62 (e-PCR), detects polymorphism
- UniSTS:259297

AU015441 (e-PCR)
- UniSTS:180962

AI661837 (e-PCR)
- UniSTS:186086

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autosome genomic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulatory ncRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

NR_002853.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (1), also known as SV1, represents the shortest transcript.

Source sequence(s)

AC116804, AK012942, CT030636

Related

ENSMUST00000247358.2
NR_027772.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2), also known as SV2, contains an alternate 3' exon compared to variant 1.

Source sequence(s)

AC116804, BF729958
NR_027773.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3), also known as SV3, contains two alternate 3' exons compared to variant 1.

Source sequence(s)

BY718621
NR_027784.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4), also known as SV1a, contains two alternate 3' exons compared to variant 1.

Source sequence(s)

AC116804, BI872620, CT030636

Related

ENSMUST00000289491.1