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    Klhl42 kelch-like 42 [ Mus musculus (house mouse) ]

    Gene ID: 232539, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl42provided by MGI
    Official Full Name
    kelch-like 42provided by MGI
    Primary source
    MGI:MGI:2444786
    See related
    Ensembl:ENSMUSG00000040102 AllianceGenome:MGI:2444786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctb9; Klhdc5; mKIAA1340; A330079N23Rik; C230080I20Rik
    Summary
    Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Predicted to be located in cytoplasm and spindle. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in early conceptus; genitourinary system; and olfactory epithelium. Orthologous to human KLHL42 (kelch like family member 42). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 10.6), adrenal adult (RPKM 8.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl42 in Genome Data Viewer
    Location:
    6 G3; 6 77.7 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146990783..147014276)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (147090615..147112778)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:146991206-146991315 Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene STARR-seq mESC enhancer starr_17814 Neighboring gene MANSC domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_17819 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:147048014-147048197 Neighboring gene predicted gene, 53326 Neighboring gene predicted gene 7571

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. Cummings CM, et al. J Biol Chem, 2009 Apr 24. PMID 19261606, Free PMC Article
    2. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule-based process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 42
    Names
    cullin-3-binding protein 9
    kelch domain containing 5
    kelch domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081237.2 → NP_001074706.1  kelch-like protein 42 isoform a

      See identical proteins and their annotated locations for NP_001074706.1

      Status: VALIDATED

      Source sequence(s)
      AC153575
      Consensus CDS
      CCDS39716.1
      UniProtKB/Swiss-Prot
      Q6ZPT4, Q8BFQ9
      UniProtKB/TrEMBL
      B2KFS7
      Related
      ENSMUSP00000042558.8, ENSMUST00000036003.8
      Conserved Domains (7) summary
      smart00612
      Location:290 → 332
      Kelch; Kelch domain
      smart00225
      Location:7 → 108
      BTB; Broad-Complex, Tramtrack and Bric a brac
      PHA03098
      Location:198 → 485
      PHA03098; kelch-like protein; Provisional
      cd14735
      Location:117 → 162
      BACK_Kelch; BTB-And-C-terminal-Kelch (BACK) domain of Kelch-like proteins
      sd00038
      Location:232 → 275
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:232 → 276
      Kelch_1; Kelch motif
      cl02518
      Location:7 → 108
      BTB; BTB/POZ domain

    2. NM_001418232.1 → NP_001405161.1  kelch-like protein 42 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153575

    3. NM_001418233.1 → NP_001405162.1  kelch-like protein 42 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153575

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      146990783..147014276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507038.5 → XP_006507101.1  kelch-like protein 42 isoform X1

      See identical proteins and their annotated locations for XP_006507101.1

      Conserved Domains (4) summary
      sd00038
      Location:179 → 223
      Kelch; KELCH repeat [structural motif]
      cd18319
      Location:4 → 101
      BTB_POZ_KLHL42; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42)
      cd18478
      Location:113 → 225
      BACK_KLHL42_KLHDC5; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42)
      pfam01344
      Location:232 → 276
      Kelch_1; Kelch motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFQ9.1 GenPept UniProtKB/Swiss-Prot:Q8BFQ9

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