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    SLC26A9 solute carrier family 26 member 9 [ Homo sapiens (human) ]

    Gene ID: 115019, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLC26A9provided by HGNC
    Official Full Name
    solute carrier family 26 member 9provided by HGNC
    Primary source
    HGNC:HGNC:14469
    See related
    Ensembl:ENSG00000174502 MIM:608481; AllianceGenome:HGNC:14469
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]
    Expression
    Biased expression in salivary gland (RPKM 19.0), stomach (RPKM 12.3) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC26A9 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (205913052..205943456, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (205177732..205208143, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205882180..205912584, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985250 Neighboring gene PM20D1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:205839492-205839993 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205889161-205889692 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:205889693-205890223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:205897002-205897542 Neighboring gene SLC26A9 and RAB7B antisense RNA 1 Neighboring gene uncharacterized LOC103021295 Neighboring gene RAB7B, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    EBI GWAS Catalog
    Genetic modifiers of cystic fibrosis-related diabetes.
    EBI GWAS Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chloride channel activity TAS
    Traceable Author Statement
    more info
     
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables solute:inorganic anion antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chloride transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chloride transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic anion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic ion transport TAS
    Traceable Author Statement
    more info
     
    involved_in oxalate transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 26 member 9
    Names
    anion transporter/exchanger protein 9
    anion transporter/exchanger-9
    solute carrier family 26 (anion exchanger), member 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052934.4NP_443166.1  solute carrier family 26 member 9 isoform a

      See identical proteins and their annotated locations for NP_443166.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes isoform a.
      Source sequence(s)
      AF314958, AF331525, BC037978
      Consensus CDS
      CCDS30990.1
      UniProtKB/Swiss-Prot
      A7E2V6, B1AVM8, B1AVM9, B7ZKK2, Q7LBE3, Q96PK9, Q96RN0
      Related
      ENSP00000356103.3, ENST00000367135.8
      Conserved Domains (2) summary
      cd07042
      Location:662730
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:57561
      sulP; high affinity sulphate transporter 1
    2. NM_134325.3NP_599152.2  solute carrier family 26 member 9 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal segment of sequence, compared to variant 1, which causes a frameshift. It encodes a protein (isoform b) with a longer C-terminus than isoform a.
      Source sequence(s)
      AF314958, AF331525, AK127491
      Consensus CDS
      CCDS30989.1
      UniProtKB/Swiss-Prot
      Q7LBE3
      UniProtKB/TrEMBL
      B3KXK1
      Related
      ENSP00000356102.2, ENST00000367134.2
      Conserved Domains (2) summary
      cd07042
      Location:662730
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:74468
      Sulfate_transp; Sulfate permease family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      205913052..205943456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509121.3XP_011507423.1  solute carrier family 26 member 9 isoform X1

      Conserved Domains (2) summary
      cd07042
      Location:573641
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      pfam00916
      Location:1379
      Sulfate_transp; Sulfate permease family
    2. XM_011509122.3XP_011507424.1  solute carrier family 26 member 9 isoform X2

      Conserved Domains (2) summary
      cd07042
      Location:498566
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:8397
      sulP; high affinity sulphate transporter 1
    3. XM_047443936.1XP_047299892.1  solute carrier family 26 member 9 isoform X3

    4. XM_011509124.3XP_011507426.1  solute carrier family 26 member 9 isoform X4

      Conserved Domains (1) summary
      pfam00916
      Location:74466
      Sulfate_transp; Sulfate permease family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      205177732..205208143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334141.1XP_054190116.1  solute carrier family 26 member 9 isoform X1

    2. XM_054334142.1XP_054190117.1  solute carrier family 26 member 9 isoform X2

    3. XM_054334143.1XP_054190118.1  solute carrier family 26 member 9 isoform X3

    4. XM_054334144.1XP_054190119.1  solute carrier family 26 member 9 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001142600.1: Suppressed sequence

      Description
      NM_001142600.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.