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    TLR5 toll like receptor 5 [ Homo sapiens (human) ]

    Gene ID: 7100, updated on 9-Dec-2024

    Summary

    Official Symbol
    TLR5provided by HGNC
    Official Full Name
    toll like receptor 5provided by HGNC
    Primary source
    HGNC:HGNC:11851
    See related
    Ensembl:ENSG00000187554 MIM:603031; AllianceGenome:HGNC:11851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLE1; TIL3; SLEB1; MELIOS
    Summary
    This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
    Expression
    Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TLR5 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (223109404..223143248, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (222347318..222381267, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223282746..223316590, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724046 Neighboring gene uncharacterized LOC107985323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:223289865-223290366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1840 Neighboring gene uncharacterized LOC124904522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:223416162-223416662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2588 Neighboring gene sushi domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 8379 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:223514378-223514878 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:223515369-223515546

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of toll-like receptor 5 (TLR5) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10052, MGC126430, MGC126431

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-1 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in toll-like receptor 5 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in toll-like receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    toll-like receptor 5
    Names
    systemic lupus erythematosus susceptibility 1
    toll/interleukin-1 receptor-like protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016244.1 RefSeqGene

      Range
      5035..38879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003268.6NP_003259.2  toll-like receptor 5 precursor

      See identical proteins and their annotated locations for NP_003259.2

      Status: REVIEWED

      Source sequence(s)
      AB060695, AB445645, AL929091, BQ025528, DB448079
      Consensus CDS
      CCDS31033.1
      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Related
      ENSP00000496355.1, ENST00000642603.2
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      223109404..223143248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711506.4XP_006711569.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006711569.1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. XM_006711505.4XP_006711568.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006711568.1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Related
      ENSP00000385458.3, ENST00000407096.7
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    3. XM_006711504.4XP_006711567.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006711567.1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    4. XM_005273243.5XP_005273300.2  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_005273300.2

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    5. XM_005273241.5XP_005273298.2  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_005273298.2

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Related
      ENSP00000519509.1, ENST00000714229.1
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    6. XM_017002208.2XP_016857697.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Related
      ENSP00000493892.2, ENST00000645434.2
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    7. XM_011509937.3XP_011508239.1  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_011508239.1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    8. XM_005273242.5XP_005273299.2  toll-like receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_005273299.2

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
      Related
      ENSP00000519510.1, ENST00000484766.2
      Conserved Domains (6) summary
      TIGR00864
      Location:554634
      PCC; polycystin cation channel protein
      sd00031
      Location:4883
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:314337
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:693837
      TIR; TIR domain
      pfam13855
      Location:288348
      LRR_8; Leucine rich repeat
      cl26793
      Location:90581
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    9. XM_047429361.1XP_047285317.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    10. XM_047429367.1XP_047285323.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      222347318..222381267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338564.1XP_054194539.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    2. XM_054338562.1XP_054194537.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    3. XM_054338558.1XP_054194533.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    4. XM_054338560.1XP_054194535.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    5. XM_054338557.1XP_054194532.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    6. XM_054338563.1XP_054194538.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    7. XM_054338559.1XP_054194534.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    8. XM_054338555.1XP_054194530.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    9. XM_054338556.1XP_054194531.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88
    10. XM_054338561.1XP_054194536.1  toll-like receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      B1AZ05, B3Y633, B9VJ63, D1CS80, D3DTB8, O15456, O60602, Q32MI2, Q32MI3
      UniProtKB/TrEMBL
      A0A2R8Y7Z4, B9VJ65, D1CS85, D1CS88