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    ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 [ Homo sapiens (human) ]

    Gene ID: 953, updated on 10-Dec-2024

    Summary

    Official Symbol
    ENTPD1provided by HGNC
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 1provided by HGNC
    Primary source
    HGNC:HGNC:3363
    See related
    Ensembl:ENSG00000138185 MIM:601752; AllianceGenome:HGNC:3363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD39; SPG64; ATP-DPH; ATPDase; NTPDase-1
    Summary
    The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 6.1), appendix (RPKM 5.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ENTPD1 in Genome Data Viewer
    Location:
    10q24.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (95694186..95877266)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (96573293..96756364)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (97471521..97637023)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3716 Neighboring gene aldehyde dehydrogenase 18 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3801 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:97454143-97454644 Neighboring gene tectonic family member 3 Neighboring gene MPRA-validated peak1056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2650 Neighboring gene ENTPD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3811 Neighboring gene Sharpr-MPRA regulatory region 13404 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:97645298-97645457 Neighboring gene MPRA-validated peak1059 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3814 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene ribosomal protein L21 pseudogene 90 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:97786197-97787396 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:97802729-97802923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2652 Neighboring gene cyclin J

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ40921, FLJ40959, DKFZp686D194, DKFZp686I093

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP phosphatase activity  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables CDP phosphatase activity  
    enables CTPase activity  
    enables DNA clamp loader activity  
    enables GDP phosphatase activity  
    enables IDP phosphatase activity  
    enables ITPase activity  
    enables UDP phosphatase activity  
    enables apyrase activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables membrane scission GTPase motor activity  
    enables nucleoside diphosphate phosphatase activity PubMed 
    enables protein binding PubMed 
    enables ribonucleoside triphosphate phosphatase activity  
    enables ribonucleoside triphosphate phosphatase activity PubMed 
    enables ribonucleoside triphosphate phosphatase activity  
    Process Evidence Code Pubs
    involved_in blood coagulation PubMed 
    involved_in cell adhesion PubMed 
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in nucleoside diphosphate catabolic process  
    involved_in platelet aggregation PubMed 
    Component Evidence Code Pubs
    located_in caveola PubMed 
    located_in extracellular exosome PubMed 
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 1
    Names
    ATP diphosphohydrolase
    CD39 antigen
    NTPDase1
    ecto-ATP diphosphohydrolase 1
    ecto-ATPDase 1
    ecto-ATPase 1
    ecto-apyrase
    lymphoid cell activation antigen
    nucleoside triphosphate diphosphohydrolase 1
    NP_001091645.1
    NP_001157650.1
    NP_001157651.1
    NP_001157653.1
    NP_001157654.1
    NP_001157655.1
    NP_001299583.1
    NP_001307845.1
    NP_001767.3
    XP_011538672.3
    XP_011538673.1
    XP_011538674.3
    XP_011538675.3
    XP_011538676.3
    XP_011538678.3
    XP_016872447.1
    XP_016872452.1
    XP_016872453.1
    XP_047281979.1
    XP_047281980.1
    XP_047281981.1
    XP_047281982.1
    XP_047281983.1
    XP_047281984.1
    XP_047281985.1
    XP_054223180.1
    XP_054223181.1
    XP_054223182.1
    XP_054223183.1
    XP_054223184.1
    XP_054223185.1
    XP_054223186.1
    XP_054223187.1
    XP_054223188.1
    XP_054223189.1
    XP_054223190.1
    XP_054223191.1
    XP_054223192.1
    XP_054223193.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042803.2 RefSeqGene

      Range
      66979..188082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001098175.2 → NP_001091645.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 2

      See identical proteins and their annotated locations for NP_001091645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon that results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AJ133133, AL356632, AL365273
      Consensus CDS
      CCDS41554.1
      UniProtKB/Swiss-Prot
      P49961
      Related
      ENSP00000390955.2, ENST00000453258.6
      Conserved Domains (1) summary
      pfam01150
      Location:47 → 478
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
    2. NM_001164178.1 → NP_001157650.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 3

      See identical proteins and their annotated locations for NP_001157650.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon that results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK301459, AK304018, AL365273, CD652289
      Consensus CDS
      CCDS53556.1
      UniProtKB/Swiss-Prot
      P49961
      Related
      ENSP00000360250.3, ENST00000371207.8
      Conserved Domains (1) summary
      pfam01150
      Location:52 → 483
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
    3. NM_001164179.2 → NP_001157651.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AL365273, AL547722
      Conserved Domains (1) summary
      pfam01150
      Location:40 → 430
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
    4. NM_001164181.1 → NP_001157653.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 5

      See identical proteins and their annotated locations for NP_001157653.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in place of the first exon and lacks an alternate internal exon compared to variant 1, that results in a distinct 5' UTR and translation initiation at a downstream start codon. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1. Both variants 5 and 8 encode the same isoform (5).
      Source sequence(s)
      AK304018, AK316009, AL365273, CD652289
      Consensus CDS
      CCDS53557.1
      UniProtKB/Swiss-Prot
      P49961
      Related
      ENSP00000442968.1, ENST00000543964.6
      Conserved Domains (1) summary
      cl17037
      Location:1 → 363
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    5. NM_001164182.2 → NP_001157654.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 6

      See identical proteins and their annotated locations for NP_001157654.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon that results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1. Both variants 6 and 7 encode the same isoform (6).
      Source sequence(s)
      AK304836, AL365273
      UniProtKB/Swiss-Prot
      P49961
      Conserved Domains (1) summary
      cl17037
      Location:1 → 333
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    6. NM_001164183.2 → NP_001157655.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 6

      See identical proteins and their annotated locations for NP_001157655.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate internal exons that results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1. Both variants 6 and 7 encode the same isoform (6).
      Source sequence(s)
      AL365273, BC047664, DC423382
      UniProtKB/Swiss-Prot
      P49961
      Conserved Domains (1) summary
      cl17037
      Location:1 → 333
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    7. NM_001312654.1 → NP_001299583.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) contains two alternate exons in place of the first two exons compared to variant 1, that results in a distinct 5' UTR and translation initiation at a downstream start codon. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1. Both variants 5 and 8 encode the same isoform (5).
      Source sequence(s)
      AK298648, AL365273
      Consensus CDS
      CCDS53557.1
      UniProtKB/Swiss-Prot
      P49961
      Conserved Domains (1) summary
      cl17037
      Location:1 → 363
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    8. NM_001320916.1 → NP_001307845.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AA748419, AK301459, BU852091, CD652289
      UniProtKB/Swiss-Prot
      P49961
      Conserved Domains (1) summary
      pfam01150
      Location:52 → 454
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
    9. NM_001776.6 → NP_001767.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform 1

      See identical proteins and their annotated locations for NP_001767.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AK304018, AL365273
      Consensus CDS
      CCDS7444.1
      UniProtKB/Swiss-Prot
      A9Z1X8, B4DWB9, B4E1X1, B7Z599, G3XAF6, P49961, Q5T561, Q5T562, Q86VV3, Q9UQQ9, Q9Y3Q9
      Related
      ENSP00000360248.4, ENST00000371205.5
      Conserved Domains (1) summary
      pfam01150
      Location:40 → 471
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      95694186..95877266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426023.1 → XP_047281979.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

    2. XM_047426024.1 → XP_047281980.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

    3. XM_011540371.3 → XP_011538673.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

      See identical proteins and their annotated locations for XP_011538673.1

      UniProtKB/Swiss-Prot
      P49961
      Conserved Domains (1) summary
      pfam01150
      Location:47 → 478
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
    4. XM_047426025.1 → XP_047281981.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

    5. XM_047426026.1 → XP_047281982.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

    6. XM_047426027.1 → XP_047281983.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X5

    7. XM_047426028.1 → XP_047281984.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X8

    8. XM_017016963.2 → XP_016872452.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X11

    9. XM_017016958.3 → XP_016872447.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X6

    10. XM_011540370.3 → XP_011538672.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    11. XM_011540372.3 → XP_011538674.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X3

    12. XM_011540373.3 → XP_011538675.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X4

    13. XM_011540374.4 → XP_011538676.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X7

    14. XM_047426029.1 → XP_047281985.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X9

    15. XM_011540376.3 → XP_011538678.3  ectonucleoside triphosphate diphosphohydrolase 1 isoform X10

    16. XM_017016964.3 → XP_016872453.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X12

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      96573293..96756364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367206.1 → XP_054223181.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

    2. XM_054367207.1 → XP_054223182.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

    3. XM_054367208.1 → XP_054223183.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X2

    4. XM_054367211.1 → XP_054223186.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X5

    5. XM_054367214.1 → XP_054223189.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X8

    6. XM_054367217.1 → XP_054223192.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X11

    7. XM_054367212.1 → XP_054223187.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X6

    8. XM_054367210.1 → XP_054223185.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X4

    9. XM_054367205.1 → XP_054223180.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1

    10. XM_054367209.1 → XP_054223184.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X3

    11. XM_054367213.1 → XP_054223188.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X7

    12. XM_054367215.1 → XP_054223190.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X9

    13. XM_054367216.1 → XP_054223191.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X10

    14. XM_054367218.1 → XP_054223193.1  ectonucleoside triphosphate diphosphohydrolase 1 isoform X12

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