NUMA1 nuclear mitotic apparatus protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NUMA1provided by HGNC
Official Full Name: nuclear mitotic apparatus protein 1provided by HGNC
Primary source: HGNC:HGNC:8059
See related: Ensembl:ENSG00000137497 MIM:164009; AllianceGenome:HGNC:8059
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NUMA; NMP-22
Summary: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Expression: Ubiquitous expression in prostate (RPKM 51.4), ovary (RPKM 49.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.4

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (72002864..72080542, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (71929780..72007446, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (71713910..71791588, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles.
Title: NuMA deficiency causes micronuclei via checkpoint-insensitive k-fiber minus-end detachment from mitotic spindle poles.
LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.
Title: LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.
Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
Title: Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer.
Title: The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer.
Diagnostic performance of nuclear matrix protein 22 and urine cytology for bladder cancer: A meta-analysis.
Title: Diagnostic performance of nuclear matrix protein 22 and urine cytology for bladder cancer: A meta-analysis.
Mechanism of spindle pole organization and instability in human oocytes.
Title: Mechanism of spindle pole organization and instability in human oocytes.
NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation.
Title: NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation.
Nuclear IGF1R interacts with NuMA and regulates 53BP1dependent DNA doublestrand break repair in colorectal cancer.
Title: Nuclear IGF1R interacts with NuMA and regulates 53BP1‑dependent DNA double‑strand break repair in colorectal cancer.
Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes.
Title: Ran-GTP Is Non-essential to Activate NuMA for Mitotic Spindle-Pole Focusing but Dynamically Polarizes HURP Near Chromosomes.
Tissue Nuclear Matrix Protein Expression 22 in Various Grades and Stages of Bladder Cancer.
Title: Tissue Nuclear Matrix Protein Expression 22 in Various Grades and Stages of Bladder Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (79)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Acute promyelocytic leukemia MedGen: C0023487 OMIM: 612376 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Interaction of HIV-1 Tat with NUMA1 in T-cells is identified by a proteomic strategy based on affinity chromatography	PubMed
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human nuclear mitotic apparatus protein 1 (NUMA1) at amino acid residues 2054-2055 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D11S2560 (e-PCR)
- UniSTS:37928

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

RH46401 (e-PCR)
- UniSTS:66645

WI-16987 (e-PCR)
- UniSTS:76634

NUMA (e-PCR)
- UniSTS:36957

D15S1477 (e-PCR)
- UniSTS:474482

D11S4713 (e-PCR)
- UniSTS:31111

G65532 (e-PCR)
- UniSTS:166573

D12S2124 (e-PCR)
- UniSTS:64446

RH102881 (e-PCR)
- UniSTS:97215

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables disordered domain specific binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables dynein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule minus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	TAS Traceable Author Statement more info	PubMed
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anastral spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astral microtubule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in astral microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleus organization	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hair follicle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic spindle elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell cortex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to spindle pole body	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metaphase plate congression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic spindle organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex region	IDA Inferred from Direct Assay more info	PubMed
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cortical microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic microtubule bundle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in lateral cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule bundle	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule minus-end	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle astral microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in spindle	TAS Traceable Author Statement more info	PubMed
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole centrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear mitotic apparatus protein 1

Names: SP-H antigen; centrophilin stabilizes mitotic spindle in mitotic cells; nuclear matrix protein-22; structural nuclear protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286561.2 → NP_001273490.1 nuclear mitotic apparatus protein 1 isoform 2

See identical proteins and their annotated locations for NP_001273490.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AB210007, BC004165, BG754891, BG771637, Z11583, Z11584

Consensus CDS

CCDS66156.1

UniProtKB/TrEMBL

Q4LE64

Related

ENSP00000351851.6, ENST00000358965.10

Conserved Domains (2) summary

TIGR02168
Location:1015 → 1717

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01576
Location:254 → 1329

Myosin_tail_1; Myosin tail
NM_006185.4 → NP_006176.2 nuclear mitotic apparatus protein 1 isoform 1

See identical proteins and their annotated locations for NP_006176.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AB210007, BC004165, BC027493, BG754891, BG771637

Consensus CDS

CCDS31633.1

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9

UniProtKB/TrEMBL

Q4LE64

Related

ENSP00000377298.4, ENST00000393695.8

Conserved Domains (2) summary

cl25732
Location:563 → 1331

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1746 → 2016

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RNA

NR_104476.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the reading frame found in variant 1.

Source sequence(s)

AP002490, BC004165, BC103765, BG754891

Related

ENST00000351960.10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

72002864..72080542 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047427023.1 → XP_047282979.1 nuclear mitotic apparatus protein 1 isoform X4
XM_047427003.1 → XP_047282959.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427016.1 → XP_047282972.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_047426995.1 → XP_047282951.1 nuclear mitotic apparatus protein 1 isoform X1
XM_017017830.2 → XP_016873319.1 nuclear mitotic apparatus protein 1 isoform X4

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

TIGR02168
Location:1015 → 1717

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01576
Location:254 → 1329

Myosin_tail_1; Myosin tail
XM_047426997.1 → XP_047282953.1 nuclear mitotic apparatus protein 1 isoform X2
XM_011545055.2 → XP_011543357.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543357.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_047427019.1 → XP_047282975.1 nuclear mitotic apparatus protein 1 isoform X4
XM_047426999.1 → XP_047282955.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427008.1 → XP_047282964.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_011545057.3 → XP_011543359.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543359.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_047427026.1 → XP_047282982.1 nuclear mitotic apparatus protein 1 isoform X4
XM_047427004.1 → XP_047282960.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427010.1 → XP_047282966.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_011545056.3 → XP_011543358.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543358.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_047427018.1 → XP_047282974.1 nuclear mitotic apparatus protein 1 isoform X4
XM_047426998.1 → XP_047282954.1 nuclear mitotic apparatus protein 1 isoform X2
XM_024448556.2 → XP_024304324.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:563 → 1331

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1746 → 2016

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_024448555.2 → XP_024304323.1 nuclear mitotic apparatus protein 1 isoform X1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_047427021.1 → XP_047282977.1 nuclear mitotic apparatus protein 1 isoform X4
XM_047427000.1 → XP_047282956.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427013.1 → XP_047282969.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_011545060.3 → XP_011543362.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543362.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_047427022.1 → XP_047282978.1 nuclear mitotic apparatus protein 1 isoform X4
XM_047427005.1 → XP_047282961.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427012.1 → XP_047282968.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_011545059.3 → XP_011543361.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543361.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_047427009.1 → XP_047282965.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_047426996.1 → XP_047282952.1 nuclear mitotic apparatus protein 1 isoform X1
XM_047427020.1 → XP_047282976.1 nuclear mitotic apparatus protein 1 isoform X4
XM_047427001.1 → XP_047282957.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427011.1 → XP_047282967.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_011545058.2 → XP_011543360.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543360.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_017017831.2 → XP_016873320.1 nuclear mitotic apparatus protein 1 isoform X4

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

TIGR02168
Location:1015 → 1717

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01576
Location:254 → 1329

Myosin_tail_1; Myosin tail
XM_047427006.1 → XP_047282962.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427014.1 → XP_047282970.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_011545062.3 → XP_011543364.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543364.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_011545066.3 → XP_011543368.1 nuclear mitotic apparatus protein 1 isoform X4

See identical proteins and their annotated locations for XP_011543368.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

TIGR02168
Location:1015 → 1717

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01576
Location:254 → 1329

Myosin_tail_1; Myosin tail
XM_011545065.3 → XP_011543367.1 nuclear mitotic apparatus protein 1 isoform X2

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

TIGR02168
Location:1015 → 1717

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam01576
Location:254 → 1329

Myosin_tail_1; Myosin tail
XM_006718564.3 → XP_006718627.1 nuclear mitotic apparatus protein 1 isoform X3

See identical proteins and their annotated locations for XP_006718627.1

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:563 → 1331

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1746 → 2016

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_011545054.3 → XP_011543356.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543356.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_047427025.1 → XP_047282981.1 nuclear mitotic apparatus protein 1 isoform X4
XM_047427017.1 → XP_047282973.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_011545064.2 → XP_011543366.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543366.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
XM_047427002.1 → XP_047282958.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427024.1 → XP_047282980.1 nuclear mitotic apparatus protein 1 isoform X4

Related

ENSP00000478624.1, ENST00000620566.4
XM_047427007.1 → XP_047282963.1 nuclear mitotic apparatus protein 1 isoform X2
XM_047427015.1 → XP_047282971.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_011545063.3 → XP_011543365.1 nuclear mitotic apparatus protein 1 isoform X1

See identical proteins and their annotated locations for XP_011543365.1

UniProtKB/TrEMBL

Q4LE64

Conserved Domains (2) summary

cl25732
Location:215 → 911

SMC_N; RecF/RecN/SMC N terminal domain

cl28033
Location:1764 → 2034

Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

71929780..72007446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054368967.1 → XP_054224942.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368943.1 → XP_054224918.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368958.1 → XP_054224933.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368931.1 → XP_054224906.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368960.1 → XP_054224935.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368937.1 → XP_054224912.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368924.1 → XP_054224899.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368963.1 → XP_054224938.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368939.1 → XP_054224914.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368950.1 → XP_054224925.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368926.1 → XP_054224901.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368971.1 → XP_054224946.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368944.1 → XP_054224919.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368952.1 → XP_054224927.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368928.1 → XP_054224903.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368932.1 → XP_054224907.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368962.1 → XP_054224937.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368949.1 → XP_054224924.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368938.1 → XP_054224913.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368925.1 → XP_054224900.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368965.1 → XP_054224940.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368940.1 → XP_054224915.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368955.1 → XP_054224930.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368927.1 → XP_054224902.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368966.1 → XP_054224941.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368945.1 → XP_054224920.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368954.1 → XP_054224929.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368933.1 → XP_054224908.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368951.1 → XP_054224926.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368964.1 → XP_054224939.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368941.1 → XP_054224916.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368953.1 → XP_054224928.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368929.1 → XP_054224904.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368968.1 → XP_054224943.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368946.1 → XP_054224921.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368956.1 → XP_054224931.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368934.1 → XP_054224909.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368961.1 → XP_054224936.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368936.1 → XP_054224911.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368948.1 → XP_054224923.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368923.1 → XP_054224898.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368970.1 → XP_054224945.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368959.1 → XP_054224934.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368942.1 → XP_054224917.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368935.1 → XP_054224910.1 nuclear mitotic apparatus protein 1 isoform X1
XM_054368957.1 → XP_054224932.1 nuclear mitotic apparatus protein 1 isoform X3

UniProtKB/Swiss-Prot

H0YH75, Q14980, Q14981, Q9BTE9
XM_054368969.1 → XP_054224944.1 nuclear mitotic apparatus protein 1 isoform X4
XM_054368947.1 → XP_054224922.1 nuclear mitotic apparatus protein 1 isoform X2
XM_054368930.1 → XP_054224905.1 nuclear mitotic apparatus protein 1 isoform X1