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    MGST1 microsomal glutathione S-transferase 1 [ Homo sapiens (human) ]

    Gene ID: 4257, updated on 27-Nov-2024

    Summary

    Official Symbol
    MGST1provided by HGNC
    Official Full Name
    microsomal glutathione S-transferase 1provided by HGNC
    Primary source
    HGNC:HGNC:7061
    See related
    Ensembl:ENSG00000008394 MIM:138330; AllianceGenome:HGNC:7061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGST; PMAN; GST12; MGST-I
    Summary
    The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
    Expression
    Biased expression in fat (RPKM 182.4), liver (RPKM 177.8) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MGST1 in Genome Data Viewer
    Location:
    12p12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (16347115..16593331)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (16224568..16466967)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (16500049..16530126)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs798 Neighboring gene Sharpr-MPRA regulatory region 3277 Neighboring gene deoxyribose-phosphate aldolase Neighboring gene egl-9 family hypoxia-inducible factor 3 pseudogene 1 Neighboring gene uncharacterized LOC101928362 Neighboring gene solute carrier family 15 member 5 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:16499669-16500598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:16501529-16502458 Neighboring gene Sharpr-MPRA regulatory region 9686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:16535292-16535885 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:16535886-16536478 Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:16602892-16603466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:16603467-16604039 Neighboring gene VISTA enhancer hs607 Neighboring gene NANOG hESC enhancer GRCh37_chr12:16703865-16704366 Neighboring gene VISTA enhancer hs336 Neighboring gene GOT2 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:16757530-16758030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:16762919-16763418 Neighboring gene LIM domain only 3 Neighboring gene VISTA enhancer hs661 Neighboring gene uncharacterized LOC105369677 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:17135721-17136920 Neighboring gene S-phase kinase associated protein 1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC14525

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipid hydroperoxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutathione transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    microsomal glutathione S-transferase 1
    Names
    glutathione S-transferase 12
    microsomal GST-1
    microsomal GST-I
    peritoneal metastasis associated long noncoding RNA
    NP_001247440.1
    NP_001247441.1
    NP_001254527.1
    NP_001401284.1
    NP_001401285.1
    NP_001401286.1
    NP_001401287.1
    NP_001401288.1
    NP_001401289.1
    NP_001401290.1
    NP_001401291.1
    NP_001401292.1
    NP_001401293.1
    NP_001401294.1
    NP_001401295.1
    NP_001401296.1
    NP_001401297.1
    NP_001401298.1
    NP_001401299.1
    NP_001401300.1
    NP_001401301.1
    NP_001401302.1
    NP_001401303.1
    NP_064696.1
    NP_665707.1
    NP_665734.1
    NP_665735.1
    XP_047284811.1
    XP_047284812.1
    XP_047284813.1
    XP_047284814.1
    XP_054228039.1
    XP_054228040.1
    XP_054228041.1
    XP_054228042.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260511.2NP_001247440.1  microsomal glutathione S-transferase 1 isoform a

      See identical proteins and their annotated locations for NP_001247440.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AW166965, BC005923, BG569388, BG617746
      Consensus CDS
      CCDS8677.1
      UniProtKB/Swiss-Prot
      A8K533, G5EA53, P10620
      UniProtKB/TrEMBL
      Q6LET6
      Conserved Domains (1) summary
      pfam01124
      Location:16149
      MAPEG; MAPEG family
    2. NM_001260512.2NP_001247441.1  microsomal glutathione S-transferase 1 isoform b

      See identical proteins and their annotated locations for NP_001247441.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC007528, AW166965, BC005923, BE568125, BG617746
      UniProtKB/Swiss-Prot
      P10620
      Conserved Domains (1) summary
      COG1232
      Location:884
      HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]
    3. NM_001267598.2NP_001254527.1  microsomal glutathione S-transferase 1 isoform c

      See identical proteins and their annotated locations for NP_001254527.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and has an alternate exon in place of the last exon compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC007528, BC056863, BG617746
      Consensus CDS
      CCDS58209.1
      UniProtKB/TrEMBL
      F5H7F6
      Related
      ENSP00000438308.1, ENST00000535309.5
    4. NM_001414355.1NP_001401284.1  microsomal glutathione S-transferase 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC007528
    5. NM_001414356.1NP_001401285.1  microsomal glutathione S-transferase 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC007528
    6. NM_001414357.1NP_001401286.1  microsomal glutathione S-transferase 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC007528
      UniProtKB/Swiss-Prot
      A8K533, G5EA53, P10620
    7. NM_001414358.1NP_001401287.1  microsomal glutathione S-transferase 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC007528
      UniProtKB/Swiss-Prot
      A8K533, G5EA53, P10620
    8. NM_001414359.1NP_001401288.1  microsomal glutathione S-transferase 1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC007528
      UniProtKB/Swiss-Prot
      A8K533, G5EA53, P10620
    9. NM_001414360.1NP_001401289.1  microsomal glutathione S-transferase 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC007528
    10. NM_001414361.1NP_001401290.1  microsomal glutathione S-transferase 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC007528
    11. NM_001414362.1NP_001401291.1  microsomal glutathione S-transferase 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC007528
    12. NM_001414363.1NP_001401292.1  microsomal glutathione S-transferase 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC007528
    13. NM_001414364.1NP_001401293.1  microsomal glutathione S-transferase 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC007528
    14. NM_001414365.1NP_001401294.1  microsomal glutathione S-transferase 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC007528
      Related
      ENSP00000442767.1, ENST00000543076.5
    15. NM_001414366.1NP_001401295.1  microsomal glutathione S-transferase 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC007528
    16. NM_001414367.1NP_001401296.1  microsomal glutathione S-transferase 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC007528
    17. NM_001414368.1NP_001401297.1  microsomal glutathione S-transferase 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC007528
    18. NM_001414369.1NP_001401298.1  microsomal glutathione S-transferase 1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC007528
    19. NM_001414370.1NP_001401299.1  microsomal glutathione S-transferase 1 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC007528
      Related
      ENSP00000442557.1, ENST00000536371.5
    20. NM_001414371.1NP_001401300.1  microsomal glutathione S-transferase 1 isoform o

      Status: REVIEWED

      Source sequence(s)
      AC007528
    21. NM_001414372.1NP_001401301.1  microsomal glutathione S-transferase 1 isoform p

      Status: REVIEWED

      Source sequence(s)
      AC007528
    22. NM_001414373.1NP_001401302.1  microsomal glutathione S-transferase 1 isoform q

      Status: REVIEWED

      Source sequence(s)
      AC007528
      UniProtKB/TrEMBL
      F5H613
      Related
      ENSP00000437988.1, ENST00000540056.5
    23. NM_001414374.1NP_001401303.1  microsomal glutathione S-transferase 1 isoform q

      Status: REVIEWED

      Source sequence(s)
      AC007528
      UniProtKB/TrEMBL
      F5H613
    24. NM_020300.5NP_064696.1  microsomal glutathione S-transferase 1 isoform a

      See identical proteins and their annotated locations for NP_064696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also called 1b) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AW166965, BC005923, BG617746
      Consensus CDS
      CCDS8677.1
      UniProtKB/Swiss-Prot
      A8K533, G5EA53, P10620
      UniProtKB/TrEMBL
      Q6LET6
      Related
      ENSP00000379513.3, ENST00000396210.8
      Conserved Domains (1) summary
      pfam01124
      Location:16149
      MAPEG; MAPEG family
    25. NM_145764.3NP_665707.1  microsomal glutathione S-transferase 1 isoform a

      See identical proteins and their annotated locations for NP_665707.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also called 1d) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AW166965, BC005923, J03746
      Consensus CDS
      CCDS8677.1
      UniProtKB/Swiss-Prot
      A8K533, G5EA53, P10620
      UniProtKB/TrEMBL
      Q6LET6
      Related
      ENSP00000379510.1, ENST00000396207.1
      Conserved Domains (1) summary
      pfam01124
      Location:16149
      MAPEG; MAPEG family
    26. NM_145791.3NP_665734.1  microsomal glutathione S-transferase 1 isoform a

      See identical proteins and their annotated locations for NP_665734.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also called 1c) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AA314967, AV655242, AW166965, BC005923
      Consensus CDS
      CCDS8677.1
      UniProtKB/Swiss-Prot
      A8K533, G5EA53, P10620
      UniProtKB/TrEMBL
      Q6LET6
      Related
      ENSP00000379512.1, ENST00000396209.5
      Conserved Domains (1) summary
      pfam01124
      Location:16149
      MAPEG; MAPEG family
    27. NM_145792.3NP_665735.1  microsomal glutathione S-transferase 1 isoform a

      See identical proteins and their annotated locations for NP_665735.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also called 1a) encodes isoform a. Variants 1-5 all encode the same isoform (a).
      Source sequence(s)
      AC007528, AW166965, BC005923, R86750
      Consensus CDS
      CCDS8677.1
      UniProtKB/Swiss-Prot
      A8K533, G5EA53, P10620
      UniProtKB/TrEMBL
      Q6LET6
      Related
      ENSP00000010404.2, ENST00000010404.6
      Conserved Domains (1) summary
      pfam01124
      Location:16149
      MAPEG; MAPEG family

    RNA

    1. NR_048545.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the first exon and lacks an internal exon compared to variant 1. This variant is represented as noncoding because the predicted protein is shorter than 60 aa, and there is no support for the existence of this protein.
      Source sequence(s)
      AW166965, BC005923, BG778603
    2. NR_048547.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the first exon and lacks an internal exon compared to variant 1. This variant is represented as noncoding because the predicted protein is shorter than 60 aa, and there is no support for the existence of this protein.
      Source sequence(s)
      AA314967, AW166965, BC005923
    3. NR_182294.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007528
    4. NR_182295.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007528

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      16347115..16593331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428855.1XP_047284811.1  microsomal glutathione S-transferase 1 isoform X1

    2. XM_047428858.1XP_047284814.1  microsomal glutathione S-transferase 1 isoform X3

    3. XM_047428856.1XP_047284812.1  microsomal glutathione S-transferase 1 isoform X2

    4. XM_047428857.1XP_047284813.1  microsomal glutathione S-transferase 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      16224568..16466967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372064.1XP_054228039.1  microsomal glutathione S-transferase 1 isoform X1

    2. XM_054372067.1XP_054228042.1  microsomal glutathione S-transferase 1 isoform X3

    3. XM_054372065.1XP_054228040.1  microsomal glutathione S-transferase 1 isoform X2

    4. XM_054372066.1XP_054228041.1  microsomal glutathione S-transferase 1 isoform X2