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    SLC35F4 solute carrier family 35 member F4 [ Homo sapiens (human) ]

    Gene ID: 341880, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC35F4provided by HGNC
    Official Full Name
    solute carrier family 35 member F4provided by HGNC
    Primary source
    HGNC:HGNC:19845
    See related
    Ensembl:ENSG00000151812 AllianceGenome:HGNC:19845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf36; c14_5373
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC35F4 in Genome Data Viewer
    Location:
    14q22.3-q23.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (57563920..57983181, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (51770870..52190085, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (58030638..58332810, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:57857288-57858283 Neighboring gene N-alpha-acetyltransferase 30, NatC catalytic subunit Neighboring gene uncharacterized LOC105370519 Neighboring gene coiled-coil domain containing 198 Neighboring gene uncharacterized LOC105370518 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:58047958-58049157 Neighboring gene serine and arginine rich splicing factor 10 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:58181078-58182074 Neighboring gene NANOG hESC enhancer GRCh37_chr14:58220473-58221005 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:58252116-58253315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:58266137-58266636 Neighboring gene NANOG hESC enhancer GRCh37_chr14:58282822-58283323 Neighboring gene RN7SK pseudogene 99 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34475 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_34518 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:58418179-58418679 Neighboring gene Sharpr-MPRA regulatory region 5436 Neighboring gene armadillo like helical domain containing 4 Neighboring gene polycomb group ring finger 3 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr14:58587185-58587752 Neighboring gene NANOG hESC enhancer GRCh37_chr14:58595390-58595891 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. Jiang Y, et al. Genet Epidemiol, 2011 Feb. PMID 21254220, Free PMC Article
    2. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Wellcome Trust Case Control Consortium. Nature, 2007 Jun 7. PMID 17554300, Free PMC Article
    3. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Wang KS, et al. Schizophr Res, 2010 Dec. PMID 20889312
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
    EBI GWAS Catalog
    Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37712

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 35 member F4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206920.2 → NP_001193849.1  solute carrier family 35 member F4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. The exon combination of this variant is inferred from partial transcript and RNA-seq alignments.
      Source sequence(s)
      AL049838, AL136520, AL161804, BC101320, BX107164
      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3
      Conserved Domains (1) summary
      COG0697
      Location:237 → 437
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    2. NM_001306087.2 → NP_001293016.1  solute carrier family 35 member F4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). The exon combination of this variant is inferred from partial transcript and RNA-seq alignments.
      Source sequence(s)
      AL049838, AL161804, BC101319, BC101321, BX107164, EG328127
      Consensus CDS
      CCDS76684.1
      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3
      UniProtKB/TrEMBL
      G3V4Z9
      Related
      ENSP00000452086.1, ENST00000556826.6
      Conserved Domains (1) summary
      COG0697
      Location:238 → 438
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    3. NM_001352011.2 → NP_001338940.1  solute carrier family 35 member F4 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804
      Conserved Domains (1) summary
      pfam06027
      Location:238 → 287
      SLC35F; Solute carrier family 35

    4. NM_001352012.2 → NP_001338941.1  solute carrier family 35 member F4 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL132668, AL136520, AL161804
      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3
      Conserved Domains (1) summary
      COG0697
      Location:216 → 416
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    5. NM_001352013.2 → NP_001338942.1  solute carrier family 35 member F4 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804

    6. NM_001352014.2 → NP_001338943.1  solute carrier family 35 member F4 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804
      Consensus CDS
      CCDS86392.1
      Related
      ENSP00000451990.1, ENST00000554729.5

    7. NM_001352015.3 → NP_001338944.1  solute carrier family 35 member F4 isoform g

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804
      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3
      Related
      ENSP00000342518.6, ENST00000339762.10
      Conserved Domains (1) summary
      COG0697
      Location:235 → 435
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    8. NM_001352016.2 → NP_001338945.1  solute carrier family 35 member F4 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804

    RNA

    1. NR_159373.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804

    2. NR_159374.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804

    3. NR_159375.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804

    4. NR_159376.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL049838, AL136520, AL161804

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      57563920..57983181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536723.4 → XP_011535025.1  solute carrier family 35 member F4 isoform X3

      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3
      Conserved Domains (1) summary
      COG0697
      Location:225 → 425
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    2. XM_011536724.4 → XP_011535026.1  solute carrier family 35 member F4 isoform X4

      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3
      Conserved Domains (1) summary
      COG0697
      Location:220 → 420
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    3. XM_011536721.4 → XP_011535023.1  solute carrier family 35 member F4 isoform X2

      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3
      Conserved Domains (1) summary
      COG0697
      Location:284 → 484
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    4. XM_011536720.4 → XP_011535022.1  solute carrier family 35 member F4 isoform X1

      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3
      Conserved Domains (1) summary
      COG0697
      Location:285 → 485
      RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]

    5. XM_047431343.1 → XP_047287299.1  solute carrier family 35 member F4 isoform X5

    6. XM_024449561.2 → XP_024305329.1  solute carrier family 35 member F4 isoform X6

    RNA

    1. XR_943418.4 RNA Sequence

    2. XR_002957548.2 RNA Sequence

    3. XR_007064010.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      51770870..52190085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375982.1 → XP_054231957.1  solute carrier family 35 member F4 isoform X3

      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3

    2. XM_054375983.1 → XP_054231958.1  solute carrier family 35 member F4 isoform X4

      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3

    3. XM_054375981.1 → XP_054231956.1  solute carrier family 35 member F4 isoform X2

      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3

    4. XM_054375980.1 → XP_054231955.1  solute carrier family 35 member F4 isoform X1

      UniProtKB/Swiss-Prot
      A4IF30, A6NDQ3

    5. XM_054375984.1 → XP_054231959.1  solute carrier family 35 member F4 isoform X5

    6. XM_054375985.1 → XP_054231960.1  solute carrier family 35 member F4 isoform X6

    RNA

    1. XR_008488863.1 RNA Sequence

    2. XR_008488864.1 RNA Sequence

    3. XR_008488862.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080455.1: Suppressed sequence

      Description
      NM_001080455.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4IF30.2 GenPept UniProtKB/Swiss-Prot:A4IF30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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