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    FNDC3B fibronectin type III domain containing 3B [ Homo sapiens (human) ]

    Gene ID: 64778, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FNDC3Bprovided by HGNC
    Official Full Name
    fibronectin type III domain containing 3Bprovided by HGNC
    Primary source
    HGNC:HGNC:24670
    See related
    Ensembl:ENSG00000075420 MIM:611909; AllianceGenome:HGNC:24670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAD104; PRO4979; YVTM2421
    Summary
    Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 11.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FNDC3B in Genome Data Viewer
    Location:
    3q26.31
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (172039578..172401669)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (174823628..175186764)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (171757368..172119459)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TMEM212 antisense RNA 1 Neighboring gene uncharacterized LOC105374218 Neighboring gene uncharacterized LOC105374217 Neighboring gene Sharpr-MPRA regulatory region 13471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:171678336-171678836 Neighboring gene FOXA motif-containing MPRA enhancer 130 Neighboring gene NANOG hESC enhancer GRCh37_chr3:171727625-171728138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171757188-171757855 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171757856-171758522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20817 Neighboring gene HNF1 motif-containing MPRA enhancer 67 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20820 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:171854185-171855008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171858305-171859128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20821 Neighboring gene Sharpr-MPRA regulatory region 1756 Neighboring gene uncharacterized LOC124906304 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171884751-171885290 Neighboring gene Sharpr-MPRA regulatory region 4529 Neighboring gene Sharpr-MPRA regulatory region 6188 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171911885-171912075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171927153-171927716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:171927717-171928279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20825 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:171940563-171941066 Neighboring gene Sharpr-MPRA regulatory region 15581 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:171973898-171974093 Neighboring gene RPS27A pseudogene 8 Neighboring gene RNA, 7SL, cytoplasmic 141, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14584 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:172018611-172019279 Neighboring gene Sharpr-MPRA regulatory region 11565 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:172032476-172033374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:172165405-172166172 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene 1 Neighboring gene growth hormone secretagogue receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis. Liu H, et al. Mol Cancer, 2018 Nov 20. PMID 30458784, Free PMC Article
    2. Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells. Liu Y, et al. Int Heart J, 2021 Nov 30. PMID 34789642
    3. Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogene FNDC3B. Cai C, et al. Cell Cycle, 2012 May 1. PMID 22510613, Free PMC Article
    4. Association between hsa_circ_0006156 expression and incidence of gastric cancer. He YX, et al. Eur Rev Med Pharmacol Sci, 2020 Mar. PMID 32271420
    5. Integrated machine learning methods identify FNDC3B as a potential prognostic biomarker and correlated with immune infiltrates in glioma. Wang X, et al. Front Immunol, 2022. PMID 36275754, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis.
      Title: Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis.
    2. circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p.
      Title: circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p.
    3. Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin.
      Title: Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin.
    4. Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis.
      Title: Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis.
    5. m[6]A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.
      Title: m(6)A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.
    6. Integrated machine learning methods identify FNDC3B as a potential prognostic biomarker and correlated with immune infiltrates in glioma.
      Title: Integrated machine learning methods identify FNDC3B as a potential prognostic biomarker and correlated with immune infiltrates in glioma.
    7. Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.
      Title: Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.
    8. Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.
      Title: Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.
    9. Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis.
      Title: Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis.
    10. Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells.
      Title: Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.
    EBI GWAS Catalog
    Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23399, MGC10002, DKFZp762K137, DKFZp686D14170

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type III domain-containing protein 3B
    Names
    HCV NS5A-binding protein 37
    factor for adipocyte differentiation 104

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135095.2 → NP_001128567.1  fibronectin type III domain-containing protein 3B

      See identical proteins and their annotated locations for NP_001128567.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AB098597, AC069259, AC069523, AI417065, AK223599, AK314478
      Consensus CDS
      CCDS3217.1
      UniProtKB/Swiss-Prot
      B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
      Related
      ENSP00000338523.4, ENST00000336824.8
      Conserved Domains (2) summary
      cd00063
      Location:572 → 666
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:886 → 947
      fn3; Fibronectin type III domain

    2. NM_022763.4 → NP_073600.3  fibronectin type III domain-containing protein 3B

      See identical proteins and their annotated locations for NP_073600.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AB098597, AC069259, AC069523, AI417065, AK223599, AK314478
      Consensus CDS
      CCDS3217.1
      UniProtKB/Swiss-Prot
      B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
      Related
      ENSP00000411242.2, ENST00000415807.7
      Conserved Domains (2) summary
      cd00063
      Location:572 → 666
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:886 → 947
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      172039578..172401669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007062.2 → XP_016862551.1  fibronectin type III domain-containing protein 3B isoform X2

    2. XM_017007064.3 → XP_016862553.1  fibronectin type III domain-containing protein 3B isoform X3

    3. XM_024453717.2 → XP_024309485.1  fibronectin type III domain-containing protein 3B isoform X1

      UniProtKB/Swiss-Prot
      B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
      Conserved Domains (2) summary
      cd00063
      Location:572 → 666
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:886 → 947
      fn3; Fibronectin type III domain

    4. XM_047448756.1 → XP_047304712.1  fibronectin type III domain-containing protein 3B isoform X2

    5. XM_047448755.1 → XP_047304711.1  fibronectin type III domain-containing protein 3B isoform X2

    6. XM_047448752.1 → XP_047304708.1  fibronectin type III domain-containing protein 3B isoform X1

      UniProtKB/Swiss-Prot
      B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8

    7. XM_047448754.1 → XP_047304710.1  fibronectin type III domain-containing protein 3B isoform X1

      UniProtKB/Swiss-Prot
      B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8

    8. XM_047448757.1 → XP_047304713.1  fibronectin type III domain-containing protein 3B isoform X2

    9. XM_024453716.2 → XP_024309484.1  fibronectin type III domain-containing protein 3B isoform X1

      UniProtKB/Swiss-Prot
      B2RB36, B3KXR8, D3DNQ7, Q53EP0, Q5U5T8, Q6PIJ3, Q6UXG1, Q6UXZ5, Q8IXB2, Q8NBU7, Q96D78, Q9H5I7, Q9NSQ8
      Related
      ENSP00000389094.1, ENST00000416957.5
      Conserved Domains (2) summary
      cd00063
      Location:572 → 666
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:886 → 947
      fn3; Fibronectin type III domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      174823628..175186764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347596.1 → XP_054203571.1  fibronectin type III domain-containing protein 3B isoform X2

    2. XM_054347601.1 → XP_054203576.1  fibronectin type III domain-containing protein 3B isoform X3

    3. XM_054347591.1 → XP_054203566.1  fibronectin type III domain-containing protein 3B isoform X1

    4. XM_054347598.1 → XP_054203573.1  fibronectin type III domain-containing protein 3B isoform X2

    5. XM_054347597.1 → XP_054203572.1  fibronectin type III domain-containing protein 3B isoform X2

    6. XM_054347594.1 → XP_054203569.1  fibronectin type III domain-containing protein 3B isoform X1

    7. XM_054347599.1 → XP_054203574.1  fibronectin type III domain-containing protein 3B isoform X2

    8. XM_054347592.1 → XP_054203567.1  fibronectin type III domain-containing protein 3B isoform X1

    9. XM_054347595.1 → XP_054203570.1  fibronectin type III domain-containing protein 3B isoform X1

    10. XM_054347593.1 → XP_054203568.1  fibronectin type III domain-containing protein 3B isoform X1

    11. XM_054347600.1 → XP_054203575.1  fibronectin type III domain-containing protein 3B isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53EP0.2 GenPept UniProtKB/Swiss-Prot:Q53EP0

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