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    RNF14 ring finger protein 14 [ Homo sapiens (human) ]

    Gene ID: 9604, updated on 27-Nov-2024

    Summary

    Official Symbol
    RNF14provided by HGNC
    Official Full Name
    ring finger protein 14provided by HGNC
    Primary source
    HGNC:HGNC:10058
    See related
    Ensembl:ENSG00000013561 MIM:605675; AllianceGenome:HGNC:10058
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARA54; HFB30; TRIAD2; HRIHFB2038
    Summary
    The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in testis (RPKM 10.0), thyroid (RPKM 8.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RNF14 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (141949337..141990292)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (142475299..142516212)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141346408..141369857)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141293283-141293820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:141303317-141303830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141308886-141309386 Neighboring gene DAP3 binding cell death enhancer 1 Neighboring gene protocadherin 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141336627-141337533 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141337534-141338439 Neighboring gene uncharacterized LOC124901095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23314 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16466 Neighboring gene CRISPRi-validated cis-regulatory element chr5.3497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16467 Neighboring gene Sharpr-MPRA regulatory region 4900 Neighboring gene mitochondrial ribosomal protein L11 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26004

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-like protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF14
    Names
    androgen receptor associated protein 54
    NP_001188294.1
    NP_004281.1
    NP_899645.1
    NP_899646.1
    NP_899647.1
    NP_899648.1
    XP_011536016.1
    XP_016865563.1
    XP_016865564.1
    XP_024302033.1
    XP_047273854.1
    XP_047273855.1
    XP_047273856.1
    XP_047273857.1
    XP_047273858.1
    XP_047273859.1
    XP_047273860.1
    XP_047273861.1
    XP_047273862.1
    XP_047273863.1
    XP_047273864.1
    XP_047273865.1
    XP_047273866.1
    XP_054209813.1
    XP_054209814.1
    XP_054209815.1
    XP_054209816.1
    XP_054209817.1
    XP_054209818.1
    XP_054209819.1
    XP_054209820.1
    XP_054209821.1
    XP_054209822.1
    XP_054209823.1
    XP_054209824.1
    XP_054209825.1
    XP_054209826.1
    XP_054209827.1
    XP_054209828.1
    XP_054209829.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201365.2NP_001188294.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_001188294.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      AC005740, BC126185, BE042895, DC396586
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
      UniProtKB/TrEMBL
      B3KN55
      Related
      ENSP00000378027.1, ENST00000394519.5
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
      cd16628
      Location:218271
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    2. NM_004290.5NP_004281.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_004281.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC005740, AF060544, BE042895, DC402536
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
      UniProtKB/TrEMBL
      B3KN55
      Related
      ENSP00000378028.2, ENST00000394520.7
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
      cd16628
      Location:218271
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    3. NM_183398.3NP_899645.1  E3 ubiquitin-protein ligase RNF14 isoform 2

      See identical proteins and their annotated locations for NP_899645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon compared to variant 1. The translation begins at a downstream start codon and results in an isoform (2) that has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC005740, AF060544, BE042895, DB456366, DC402536
      Consensus CDS
      CCDS4271.1
      UniProtKB/Swiss-Prot
      Q9UBS8
      Related
      ENSP00000378022.2, ENST00000394514.6
      Conserved Domains (3) summary
      smart00647
      Location:163224
      IBR; In Between Ring fingers
      cd16628
      Location:92145
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:251307
      IBR; IBR domain, a half RING-finger domain
    4. NM_183399.3NP_899646.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_899646.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      AC005740, AF060544, BE042895, DC396586
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
      UniProtKB/TrEMBL
      B3KN55
      Related
      ENSP00000348462.1, ENST00000356143.5
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
      cd16628
      Location:218271
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    5. NM_183400.3NP_899647.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_899647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a segment within the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      AC005740, AF060544, BE042895, DC402536
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
      UniProtKB/TrEMBL
      B3KN55
      Related
      ENSP00000324956.3, ENST00000347642.7
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
      cd16628
      Location:218271
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    6. NM_183401.3NP_899648.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_899648.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      AC005740, AF060544, BE042895, DC358984
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
      UniProtKB/TrEMBL
      B3KN55
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
      cd16628
      Location:218271
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      141949337..141990292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417908.1XP_047273864.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    2. XM_047417904.1XP_047273860.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    3. XM_047417903.1XP_047273859.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    4. XM_047417899.1XP_047273855.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    5. XM_047417907.1XP_047273863.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    6. XM_047417898.1XP_047273854.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    7. XM_047417906.1XP_047273862.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    8. XM_047417905.1XP_047273861.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    9. XM_047417909.1XP_047273865.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    10. XM_024446265.2XP_024302033.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      cl02687
      Location:779
      RWD; RWD domain
    11. XM_047417902.1XP_047273858.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    12. XM_017010075.3XP_016865564.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      cl02687
      Location:779
      RWD; RWD domain
    13. XM_047417900.1XP_047273856.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    14. XM_047417901.1XP_047273857.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    15. XM_011537714.4XP_011536016.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      See identical proteins and their annotated locations for XP_011536016.1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
      UniProtKB/TrEMBL
      B3KN55
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7133
      RWD; RWD domain
      cd16628
      Location:218271
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
    16. XM_047417910.1XP_047273866.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    17. XM_017010074.3XP_016865563.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      cl02687
      Location:779
      RWD; RWD domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      142475299..142516212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353851.1XP_054209826.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    2. XM_054353843.1XP_054209818.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    3. XM_054353842.1XP_054209817.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    4. XM_054353839.1XP_054209814.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    5. XM_054353848.1XP_054209823.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    6. XM_054353838.1XP_054209813.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    7. XM_054353847.1XP_054209822.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    8. XM_054353844.1XP_054209819.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    9. XM_054353853.1XP_054209828.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    10. XM_054353850.1XP_054209825.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    11. XM_054353841.1XP_054209816.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    12. XM_054353852.1XP_054209827.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    13. XM_054353845.1XP_054209820.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    14. XM_054353854.1XP_054209829.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229
    15. XM_054353840.1XP_054209815.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    16. XM_054353846.1XP_054209821.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      A0AV26, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0, Q9UBS8
    17. XM_054353849.1XP_054209824.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      B7Z229