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    STK31 serine/threonine kinase 31 [ Homo sapiens (human) ]

    Gene ID: 56164, updated on 27-Nov-2024

    Summary

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    Official Symbol
    STK31provided by HGNC
    Official Full Name
    serine/threonine kinase 31provided by HGNC
    Primary source
    HGNC:HGNC:11407
    See related
    Ensembl:ENSG00000196335 MIM:605790; AllianceGenome:HGNC:11407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TDRD8; SGK396
    Summary
    This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 35.6) See more
    Orthologs
    mouse all
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    Genomic context

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    See STK31 in Genome Data Viewer
    Location:
    7p15.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (23710082..23832513)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (23849359..23971746)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (23749838..23872132)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 126 Neighboring gene FCF1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23694754-23695254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25739 Neighboring gene family with sequence similarity 221 member A Neighboring gene NANOG hESC enhancer GRCh37_chr7:23763155-23763682 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:23763683-23764210 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 pseudogene 3 Neighboring gene MPRA-validated peak6439 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23867512-23868012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23884086-23884586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23884587-23885087 Neighboring gene TPT1 pseudogene 7 Neighboring gene small nucleolar RNA U13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:23958471-23959023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18016 Neighboring gene uncharacterized LOC105375188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. Kuo PL, et al. PLoS One, 2014. PMID 24667656, Free PMC Article
    2. STK31 maintains the undifferentiated state of colon cancer cells. Fok KL, et al. Carcinogenesis, 2012 Nov. PMID 22828137
    3. STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model. Bae DH, et al. Oncol Rep, 2021 Apr. PMID 33649810, Free PMC Article
    4. STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer. Zhong L, et al. Oncotarget, 2017 Apr 11. PMID 28412729, Free PMC Article
    5. The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer. Zhang K, et al. Oncotarget, 2017 May 23. PMID 28422722, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer.
      Title: Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer.
    2. STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model.
      Title: STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model.
    3. Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival.
      Title: Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival.
    4. STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/betacatenin pathway and feedback regulation by cmyc.
      Title: STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/β‑catenin pathway and feedback regulation by c‑myc.
    5. FBLN1 and STK31 can be possible screening and differentiating biomarkers of colorectal cancer
      Title: Serum FBLN1 and STK31 as biomarkers of colorectal cancer and their ability to noninvasively differentiate colorectal cancer from benign polyps.
    6. Relative STK31 expression level was significantly higher in patients with lymph node metastasis. STK31 expression levels in primary tumorous tissues of metastatic patients were significantly higher than in ANCTs and in lymph nodes samples, both at the RNA level and the protein level.
      Title: STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer.
    7. Study demonstrates that, except the testes, STK31 is not expressed in normal tissues but aberrantly expressed in pancreatic cancer (PC) tissues, indicating that STK31 is a cancer-testis (CT) gene in PC. STK31 is reactivated by demethylation and, significantly higher in relapsed patients, or patients with advanced pathologic stage or poorer prognosis, suggesting that STK31 might be of potential clinical value.
      Title: The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer.
    8. The human papillomavirus type 16 oncogene E7 may affect STK31 expression through a DNA methylation-mediated mechanism.
      Title: Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer.
    9. the aberrant expression of STK31 contributes to tumorigenicity in somatic cancer cells
      Title: STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells.
    10. High STK31 expression is associated with colon cancer.
      Title: STK31 maintains the undifferentiated state of colon cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16102

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 31
    Names
    serine/threonine-protein kinase NYD-SPK
    sugen kinase 396
    testis tissue sperm-binding protein Li 78m
    tudor domain containing 8
    NP_001247433.1
    NP_001247434.1
    NP_113602.2
    NP_116562.2
    XP_006715821.1
    XP_011513751.2
    XP_011513752.1
    XP_011513754.2
    XP_054214627.1
    XP_054214628.1
    XP_054214629.1
    XP_054214630.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260504.2 → NP_001247433.1  serine/threonine-protein kinase 31 isoform b

      See identical proteins and their annotated locations for NP_001247433.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AA315045, AC003087, AC008176, AF332194, AK131214, DA533364
      Consensus CDS
      CCDS43556.1
      UniProtKB/TrEMBL
      A0A140VKG1, A4D160
      Related
      ENSP00000346660.3, ENST00000354639.7
      Conserved Domains (2) summary
      cd20430
      Location:38 → 112
      Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
      cl21453
      Location:805 → 945
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001260505.2 → NP_001247434.1  serine/threonine-protein kinase 31 isoform c

      See identical proteins and their annotated locations for NP_001247434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC003087, AC008176, AK302689
      Consensus CDS
      CCDS59049.1
      UniProtKB/TrEMBL
      A4D159
      Related
      ENSP00000411852.2, ENST00000433467.6
      Conserved Domains (3) summary
      cd04508
      Location:89 → 129
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:29 → 147
      TUDOR; Tudor domain
      cl21453
      Location:802 → 986
      PKc_like; Protein Kinases, catalytic domain

    3. NM_031414.5 → NP_113602.2  serine/threonine-protein kinase 31 isoform a

      See identical proteins and their annotated locations for NP_113602.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC003087, BC059374, DB065148
      Consensus CDS
      CCDS5386.1
      UniProtKB/Swiss-Prot
      B4DZ06, B7WPP5, C9J4F9, Q6PCD3, Q9BXH8, Q9BXU1
      UniProtKB/TrEMBL
      A4D159
      Related
      ENSP00000348132.3, ENST00000355870.8
      Conserved Domains (3) summary
      cd04508
      Location:89 → 129
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:29 → 147
      TUDOR; Tudor domain
      cl21453
      Location:802 → 921
      PKc_like; Protein Kinases, catalytic domain

    4. NM_032944.4 → NP_116562.2  serine/threonine-protein kinase 31 isoform b

      See identical proteins and their annotated locations for NP_116562.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice-site in the 5' end that results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC003087, AC008176, BC059374, DB095141
      Consensus CDS
      CCDS43556.1
      UniProtKB/TrEMBL
      A0A140VKG1, A4D160
      Conserved Domains (2) summary
      cd20430
      Location:38 → 112
      Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
      cl21453
      Location:805 → 945
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_048542.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in a 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA315045, AC003087, AC008176, AK131214, BC033018, DB089624

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      23710082..23832513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515452.4 → XP_011513754.2  serine/threonine-protein kinase 31 isoform X3

      UniProtKB/TrEMBL
      A4D160

    2. XM_011515449.4 → XP_011513751.2  serine/threonine-protein kinase 31 isoform X1

      UniProtKB/TrEMBL
      A4D160
      Related
      ENSP00000519677.1, ENST00000528479.6

    3. XM_006715758.5 → XP_006715821.1  serine/threonine-protein kinase 31 isoform X4

      UniProtKB/TrEMBL
      A4D159
      Conserved Domains (3) summary
      cd04508
      Location:89 → 129
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:29 → 147
      TUDOR; Tudor domain
      cl21453
      Location:624 → 743
      PKc_like; Protein Kinases, catalytic domain

    4. XM_011515450.2 → XP_011513752.1  serine/threonine-protein kinase 31 isoform X2

      See identical proteins and their annotated locations for XP_011513752.1

      UniProtKB/TrEMBL
      A0A140VKG1, A4D160
      Conserved Domains (2) summary
      cd20430
      Location:38 → 112
      Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
      cl21453
      Location:805 → 945
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      23849359..23971746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358654.1 → XP_054214629.1  serine/threonine-protein kinase 31 isoform X3

    2. XM_054358652.1 → XP_054214627.1  serine/threonine-protein kinase 31 isoform X1

    3. XM_054358655.1 → XP_054214630.1  serine/threonine-protein kinase 31 isoform X4

    4. XM_054358653.1 → XP_054214628.1  serine/threonine-protein kinase 31 isoform X2

      UniProtKB/TrEMBL
      A0A140VKG1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001122833.1: Suppressed sequence

      Description
      NM_001122833.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXU1.2 GenPept UniProtKB/Swiss-Prot:Q9BXU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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