DMTF1 cyclin D binding myb like transcription factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DMTF1provided by HGNC
Official Full Name: cyclin D binding myb like transcription factor 1provided by HGNC
Primary source: HGNC:HGNC:14603
See related: Ensembl:ENSG00000135164 MIM:608491; AllianceGenome:HGNC:14603
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DMP1; DMTF; MRUL; hDMP1
Summary: This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Expression: Ubiquitous expression in testis (RPKM 18.8), lymph node (RPKM 11.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.12

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (87152453..87196325)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (88402370..88446262)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (86781769..86825641)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanisms regulating DMTF1beta/gamma expression and their functional interplay with DMTF1alpha.
Title: Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α.
Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53.
Title: Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53.
the results of the study demonstrated that miR6753p directly regulated the expression of DMTF1, which contributed to the further regulation of Colorectal cancer cell proliferation.
Title: miR‑675 promotes colorectal cancer cell growth dependent on tumor suppressor DMTF1.
DMTF1 is hemizygously deleted in 35-42% of human cancers and is associated with longer survival. [review]
Title: c-MYB and DMTF1 in Cancer.
Cisplatin sensitivity in breast cancer cells is associated with a DMTF1beta splice variant expression.
Title: Cisplatin sensitivity in breast cancer cells is associated with particular DMTF1 splice variant expression.
Study demonstrated that an alternative cyclin D-binding myb-like transcription factor 1 (DMTF1) pre-mRNA splicing isoform, DMTF1 beta, is increasingly expressed in breast cancer and promotes mammary tumorigenesis in a transgenic mouse model. [review].
Title: From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.
Low DMTF1 expression is associated with in bladder cancer.
Title: MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1.
findings imply that DMP1alpha- and beta-ratios are tightly regulated in hematopoietic cells and DMP1beta antagonizes DMP1alpha transcriptional regulation of ARF resulting in the alteration of cellular control with a gain in proliferation
Title: Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.
This study reveals a pivotal role of combined Dmp1 loss and cyclin D1 overexpression in breast cancer.
Title: Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.
LOH for hDMP1 was associated with luminal A category and longer relapse-free survival
Title: Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH65726 (e-PCR)
- UniSTS:57643

SHGC-64937 (e-PCR)
- UniSTS:31048

STS-T90340 (e-PCR)
- UniSTS:6758

RH78780 (e-PCR)
- UniSTS:27531

RH118922 (e-PCR)
- UniSTS:138924

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: cyclin-D-binding Myb-like transcription factor 1

Names: cyclin D-binding Myb-like protein; cyclin-D-interacting Myb-like protein 1; hDMTF1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029536.1 RefSeqGene

Range

5093..48965

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001142326.2 → NP_001135798.1 cyclin-D-binding Myb-like transcription factor 1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks a 5' coding exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b) with a shorter N-terminus compared to isoform a.

Source sequence(s)

AC005076, AF052102, AK296211, BC070064

Consensus CDS

CCDS47633.1

UniProtKB/TrEMBL

E7EPA0

Related

ENSP00000412532.2, ENST00000432937.6

Conserved Domains (4) summary

smart00717
Location:186 → 242

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:250 → 300

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:186 → 241

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:140 → 196

Myb_DNA-bind_6; Myb-like DNA-binding domain
NM_001142327.2 → NP_001135799.1 cyclin-D-binding Myb-like transcription factor 1 isoform a

See identical proteins and their annotated locations for NP_001135799.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AF084530, BC007418

Consensus CDS

CCDS5601.1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Related

ENSP00000332171.7, ENST00000331242.12

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
NM_021145.4 → NP_066968.3 cyclin-D-binding Myb-like transcription factor 1 isoform a

See identical proteins and their annotated locations for NP_066968.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a, also known as DMP1alpha). Variants 1 and 2 encode the same isoform.

Source sequence(s)

AC005076, BC007447, BC070064, DB061156

Consensus CDS

CCDS5601.1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Related

ENSP00000378193.5, ENST00000394703.9

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

RNA

NR_024549.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as in variant 1, would result in nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF202145, BC007418

Related

ENST00000447863.5
NR_024550.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as in variant 1, would result in nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF202144, BC007418

Related

ENST00000579677.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

87152453..87196325

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421106.1 → XP_047277062.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421102.1 → XP_047277058.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421123.1 → XP_047277079.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_047421100.1 → XP_047277056.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_024447017.2 → XP_024302785.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
XM_047421107.1 → XP_047277063.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421111.1 → XP_047277067.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421103.1 → XP_047277059.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_024447018.2 → XP_024302786.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
XM_047421116.1 → XP_047277072.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_024447022.2 → XP_024302790.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
XM_047421131.1 → XP_047277087.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_024447016.2 → XP_024302784.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
XM_047421126.1 → XP_047277082.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_047421119.1 → XP_047277075.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_047421133.1 → XP_047277089.1 cyclin-D-binding Myb-like transcription factor 1 isoform X5
XM_011516737.1 → XP_011515039.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

See identical proteins and their annotated locations for XP_011515039.1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
XM_017012868.1 → XP_016868357.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

COG5147
Location:105 → 438

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain
XM_047421118.1 → XP_047277074.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_047421134.1 → XP_047277090.1 cyclin-D-binding Myb-like transcription factor 1 isoform X5
XM_024447020.2 → XP_024302788.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
XM_047421128.1 → XP_047277084.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_047421117.1 → XP_047277073.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_047421122.1 → XP_047277078.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_011516739.4 → XP_011515041.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2

See identical proteins and their annotated locations for XP_011515041.1

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (4) summary

smart00717
Location:233 → 289

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:297 → 347

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00249
Location:233 → 288

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:187 → 243

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_017012870.3 → XP_016868359.1 cyclin-D-binding Myb-like transcription factor 1 isoform X5

UniProtKB/TrEMBL

E7EPA0
XM_047421108.1 → XP_047277064.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421101.1 → XP_047277057.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421104.1 → XP_047277060.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421125.1 → XP_047277081.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_024447019.2 → XP_024302787.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
XM_047421120.1 → XP_047277076.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_047421112.1 → XP_047277068.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421105.1 → XP_047277061.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421127.1 → XP_047277083.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_024447021.2 → XP_024302789.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

UniProtKB/TrEMBL

E7EPA0

Conserved Domains (3) summary

pfam00249
Location:274 → 329

Myb_DNA-binding; Myb-like DNA-binding domain

pfam13921
Location:228 → 284

Myb_DNA-bind_6; Myb-like DNA-binding domain

cl28544
Location:89 → 438

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
XM_047421130.1 → XP_047277086.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_047421121.1 → XP_047277077.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_047421099.1 → XP_047277055.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421109.1 → XP_047277065.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421110.1 → XP_047277066.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_047421113.1 → XP_047277069.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_047421124.1 → XP_047277080.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_047421129.1 → XP_047277085.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_047421114.1 → XP_047277070.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_047421115.1 → XP_047277071.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_047421132.1 → XP_047277088.1 cyclin-D-binding Myb-like transcription factor 1 isoform X4
XM_047421135.1 → XP_047277091.1 cyclin-D-binding Myb-like transcription factor 1 isoform X6

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

88402370..88446262

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054359466.1 → XP_054215441.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359456.1 → XP_054215431.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359467.1 → XP_054215442.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359469.1 → XP_054215444.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359461.1 → XP_054215436.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359479.1 → XP_054215454.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359465.1 → XP_054215440.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359494.1 → XP_054215469.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359459.1 → XP_054215434.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359489.1 → XP_054215464.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359482.1 → XP_054215457.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359498.1 → XP_054215473.1 cyclin-D-binding Myb-like transcription factor 1 isoform X5
XM_054359454.1 → XP_054215429.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359490.1 → XP_054215465.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359481.1 → XP_054215456.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359500.1 → XP_054215475.1 cyclin-D-binding Myb-like transcription factor 1 isoform X5
XM_054359460.1 → XP_054215435.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359492.1 → XP_054215467.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359480.1 → XP_054215455.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359485.1 → XP_054215460.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359475.1 → XP_054215450.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359497.1 → XP_054215472.1 cyclin-D-binding Myb-like transcription factor 1 isoform X5
XM_054359455.1 → XP_054215430.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359464.1 → XP_054215439.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359486.1 → XP_054215461.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359458.1 → XP_054215433.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359462.1 → XP_054215437.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359470.1 → XP_054215445.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359471.1 → XP_054215446.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359472.1 → XP_054215447.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359495.1 → XP_054215470.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359473.1 → XP_054215448.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359474.1 → XP_054215449.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359493.1 → XP_054215468.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359484.1 → XP_054215459.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359457.1 → XP_054215432.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359463.1 → XP_054215438.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359488.1 → XP_054215463.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359468.1 → XP_054215443.1 cyclin-D-binding Myb-like transcription factor 1 isoform X1

UniProtKB/Swiss-Prot

B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
XM_054359483.1 → XP_054215458.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359477.1 → XP_054215452.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359478.1 → XP_054215453.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359487.1 → XP_054215462.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359476.1 → XP_054215451.1 cyclin-D-binding Myb-like transcription factor 1 isoform X2
XM_054359491.1 → XP_054215466.1 cyclin-D-binding Myb-like transcription factor 1 isoform X3
XM_054359499.1 → XP_054215474.1 cyclin-D-binding Myb-like transcription factor 1 isoform X5
XM_054359502.1 → XP_054215477.1 cyclin-D-binding Myb-like transcription factor 1 isoform X7
XM_054359496.1 → XP_054215471.1 cyclin-D-binding Myb-like transcription factor 1 isoform X4
XM_054359501.1 → XP_054215476.1 cyclin-D-binding Myb-like transcription factor 1 isoform X6