PPP6C protein phosphatase 6 catalytic subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPP6Cprovided by HGNC
Official Full Name: protein phosphatase 6 catalytic subunitprovided by HGNC
Primary source: HGNC:HGNC:9323
See related: Ensembl:ENSG00000119414 MIM:612725; AllianceGenome:HGNC:9323
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PP6; PP6C
Summary: This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 20.0), fat (RPKM 18.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q33.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (125146573..125189803, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (137344915..137388140, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (127908852..127952082, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis.
Title: The protein phosphatase PP6 promotes RIPK1-dependent PANoptosis.
M6A-induced transcription factor IRF5 contributes to the progression of cervical cancer by upregulating PPP6C.
Title: M6A-induced transcription factor IRF5 contributes to the progression of cervical cancer by upregulating PPP6C.
PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFalpha-mediated cell death.
Title: PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP(L) to promote TNFα-mediated cell death.
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.
Title: PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.
MiR-20a-5p functions as a potent tumor suppressor by targeting PPP6C in acute myeloid leukemia.
Title: MiR-20a-5p functions as a potent tumor suppressor by targeting PPP6C in acute myeloid leukemia.
Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells.
Title: Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells.
PPP6C Negatively Regulates STING-Dependent Innate Immune Responses.
Title: PPP6C Negatively Regulates STING-Dependent Innate Immune Responses.
Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Title: Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.
Data suggest that this Plk1-PP6 interaction generates a feedback loop that coordinates and reinforces the activities of Plk1 and Aurora A during mitotic entry and is terminated by the degradation of Plk1 during mitotic exit. Thus, a mechanism for the previously puzzling observation of the Plk1-dependent regulation of Aurora A has been identified.
Title: Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.
PP6 rapidly interacts with ASK3 in an osmolality-dependent manner, and it inactivates ASK3 to induce RVI and, thereby, cell survival under hyperosmotic stress.
Title: A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, protein phosphatase 6, catalytic subunit (PPP6C), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N25718 (e-PCR)
- UniSTS:5250

WI-13793 (e-PCR)
- UniSTS:11153

RH102096 (e-PCR)
- UniSTS:96430

D9S991E (e-PCR)
- UniSTS:151237

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	TAS Traceable Author Statement more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGAS/STING signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 6 catalytic subunit

Names: serine/threonine protein phosphatase catalytic subunit

NP_001116827.1

EC 3.1.3.16

NP_001116841.1

EC 3.1.3.16

NP_002712.1

EC 3.1.3.16

XP_011517149.1

EC 3.1.3.16

XP_047279522.1

EC 3.1.3.16

XP_047279523.1

EC 3.1.3.16

XP_047279524.1

EC 3.1.3.16

XP_054219214.1

EC 3.1.3.16

XP_054219215.1

EC 3.1.3.16

XP_054219216.1

EC 3.1.3.16

XP_054219217.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001123355.2 → NP_001116827.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform a

See identical proteins and their annotated locations for NP_001116827.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longest transcript; it encodes the longest isoform (a).

Source sequence(s)

AA251321, AL445930, BC006990, CB250498, DB037210, DC334216

Consensus CDS

CCDS48018.1

UniProtKB/Swiss-Prot

O00743

Related

ENSP00000392147.1, ENST00000451402.5

Conserved Domains (1) summary

cd07415
Location:5 → 326

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
NM_001123369.2 → NP_001116841.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform c

See identical proteins and their annotated locations for NP_001116841.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks one coding exon compared to variant 1 and encodes isoform c, which is shorter than isoform a.

Source sequence(s)

AA251321, AL445930, BC006990, CB250498, DC369815

Consensus CDS

CCDS48019.1

UniProtKB/Swiss-Prot

O00743

Related

ENSP00000411744.1, ENST00000415905.5

Conserved Domains (1) summary

cd07415
Location:5 → 267

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
NM_002721.5 → NP_002712.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform b

See identical proteins and their annotated locations for NP_002712.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the coding region, compared to variant 1; it encodes a shorter isoform (b).

Source sequence(s)

AA251321, AL445930, BC006990, CB250498, DB037210

Consensus CDS

CCDS6861.1

UniProtKB/Swiss-Prot

B2R5V6, B7Z2W9, B7Z5K9, O00743, Q5U0A2, Q9UIC9

UniProtKB/TrEMBL

A0A024R861

Related

ENSP00000362648.4, ENST00000373547.9

Conserved Domains (1) summary

cd07415
Location:5 → 289

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

125146573..125189803 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047423566.1 → XP_047279522.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X1
XM_047423568.1 → XP_047279524.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X3
XM_011518847.4 → XP_011517149.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

Conserved Domains (2) summary

PTZ00239
Location:15 → 293

PTZ00239; serine/threonine protein phosphatase 2A; Provisional

cd07415
Location:13 → 277

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
XM_047423567.1 → XP_047279523.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

137344915..137388140 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054363239.1 → XP_054219214.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X1
XM_054363242.1 → XP_054219217.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X3
XM_054363240.1 → XP_054219215.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X2
XM_054363241.1 → XP_054219216.1 serine/threonine-protein phosphatase 6 catalytic subunit isoform X2