Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prkar1bprovided by RGD
Official Full Name: protein kinase cAMP-dependent type I regulatory subunit betaprovided by RGD
Primary source: RGD:3392
See related: EnsemblRapid:ENSRNOG00000028733 AllianceGenome:RGD:3392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RIbeta; RGD1563094
Summary: Enables cAMP binding activity and cAMP-dependent protein kinase regulator activity. Involved in modulation of chemical synaptic transmission; positive regulation of fear response; and regulation of protein kinase activity. Part of cAMP-dependent protein kinase complex. Orthologous to human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 433.8), Testes (RPKM 43.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (20606066..20738766)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (15492233..15624942)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (17614536..17713567)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of the RIbeta subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.
Title: Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prkar1b (e-PCR), detects polymorphism
- UniSTS:507176

Prkar1b (e-PCR), detects polymorphism
- UniSTS:144259

RH132420 (e-PCR)
- UniSTS:215703

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables cAMP-dependent protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A catalytic subunit binding	IC Inferred by Curator more info	PubMed
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell communication	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of cAMP-dependent protein kinase complex	IEA Inferred from Electronic Annotation more info
part_of cAMP-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cAMP-dependent protein kinase type I-beta regulatory subunit

Names: cAMP dependent protein kinase, subunit type 1 beta; protein kinase cAMP-dependent type 1 regulatory subunit beta; protein kinase, cAMP dependent regulatory, type I, beta; protein kinase, cAMP-dependent, regulatory subunit type I beta

NP_001028851.2

EC 2.7.11.1

NP_001405604.1

EC 2.7.11.1

XP_038945043.1

EC 2.7.11.1

XP_038945044.1

EC 2.7.11.1

XP_038945045.1

EC 2.7.11.1

XP_038945046.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033679.2 → NP_001028851.2 cAMP-dependent protein kinase type I-beta regulatory subunit isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

F1M9X5, Q3SWU5

Related

ENSRNOP00000033202.7, ENSRNOT00000031896.8

Conserved Domains (2) summary

COG0664
Location:227 → 337

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:233 → 348

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001418675.1 → NP_001405604.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P81377

Related

ENSRNOP00000083988.2, ENSRNOT00000101865.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

20606066..20738766

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089117.2 → XP_038945045.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

UniProtKB/Swiss-Prot

P81377

UniProtKB/TrEMBL

A0A8I6A184

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_039089116.2 → XP_038945044.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

UniProtKB/Swiss-Prot

P81377

UniProtKB/TrEMBL

A0A8I6A184

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_039089115.2 → XP_038945043.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

UniProtKB/Swiss-Prot

P81377

UniProtKB/TrEMBL

A0A8I6A184

Conserved Domains (2) summary

cd12102
Location:11 → 64

DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase

cd00038
Location:255 → 370

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
XM_039089118.2 → XP_038945046.1 cAMP-dependent protein kinase type I-beta regulatory subunit isoform X2

UniProtKB/TrEMBL

Q5BJR2

Conserved Domains (1) summary

cd00038
Location:103 → 218

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...