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    CG6295 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6295provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039471
    Locus tag
    Dmel_CG6295
    See related
    AllianceGenome:FB:FBgn0039471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    DmelL6; Dmel\CG6295
    Summary
    Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6295 in Genome Data Viewer
    Location:
    97D13-97D13; 3-92 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27005899..27007055, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22831621..22832777, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila. Kohyama-Koganeya A, et al. PLoS One, 2017. PMID 28045997, Free PMC Article
    2. Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements. Sociale M, et al. Cell Rep, 2018 Jan 23. PMID 29386138
    3. Other ways to skin a cat: activating SREBP without Scap. Ozdemir C, et al. Fly (Austin), 2011 Jan-Mar. PMID 20935466, Free PMC Article
    4. Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. Matthews KA, et al. Genetics, 2009 Jan. PMID 19015545, Free PMC Article
    5. Fatty acid auxotrophy in Drosophila larvae lacking SREBP. Kunte AS, et al. Cell Metab, 2006 Jun. PMID 16753579

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6295-PA
    triglyceride lipase
    NP_651521.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27005899..27007055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143264.2 → NP_651521.1  uncharacterized protein Dmel_CG6295 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VB93
      Related
      FBpp0084449, FBtr0085077
      Conserved Domains (1) summary
      cd00707
      Location:64 → 330
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB93 Q9VB93

    Gene LinkOut

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