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    Adgf-E Adenosine deaminase-related growth factor E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgf-Eprovided by FlyBase
    Official Full Name
    Adenosine deaminase-related growth factor Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033952
    Locus tag
    Dmel_CG10143
    See related
    AllianceGenome:FB:FBgn0033952
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADGF-E; adgfe; CG10143; Dmel\CG10143
    Summary
    Predicted to be involved in inosine biosynthetic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adgf-E in Genome Data Viewer
    Location:
    51B7-51B8; 2-72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14656798..14658755, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10544303..10546260, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine. Zurovec M, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904370, Free PMC Article
    2. The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins. Charlab R, et al. Gene, 2001 Apr 4. PMID 11311551
    3. Characterization of the adenosine deaminase-related growth factor (ADGF) gene family in Drosophila. Maier SA, et al. Gene, 2001 Dec 12. PMID 11738815
    4. Delineating Purinergic Signaling in Drosophila. Volonté C, et al. Int J Mol Sci, 2022 Dec 2. PMID 36499534, Free PMC Article
    5. Differential response of Drosophila cell lines to extracellular adenosine. Fleischmannova J, et al. Insect Biochem Mol Biol, 2012 May. PMID 22266077

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables catalytic activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in adenosine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in adenosine catabolic process IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    involved_in inosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase-related growth factor E
    Names
    Adgf-E-PA
    CG10143-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14656798..14658755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137133.2 → NP_610977.1  adenosine deaminase-related growth factor E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KGG1, Q8MZ84
      Related
      FBpp0086611, FBtr0087482
      Conserved Domains (3) summary
      cd01321
      Location:105 → 519
      ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
      TIGR01431
      Location:52 → 527
      adm_rel; adenosine deaminase-related growth factor
      pfam08451
      Location:46 → 125
      A_deaminase_N; Adenosine/AMP deaminase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KGG1 Q7KGG1
    Q8MZ84 Q8MZ84

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