Mycl v-myc avian myelocytomatosis viral oncogene lung carcinoma derived [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myclprovided by MGI
Official Full Name: v-myc avian myelocytomatosis viral oncogene lung carcinoma derivedprovided by MGI
Primary source: MGI:MGI:96799
See related: Ensembl:ENSMUSG00000028654 AllianceGenome:MGI:96799
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L-myc; Lmyc1; Mycl1; Lmyc-1; bHLHe38
Summary: This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]
Expression: Broad expression in whole brain E14.5 (RPKM 22.3), CNS E11.5 (RPKM 19.2) and 19 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4 D2.2; 4 57.36 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (122889414..122896278)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (122995588..123002490)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
Title: The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells.
Deletion of Mycl in two genetically engineered models of SCLC resulted in strong suppression of SCLC
Title: Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.
Mycl1 is expressed exclusively by dendritic cells; unlike c-Myc, the L-Myc transcription factor is not repressed by interferons, and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation
Title: L-Myc expression by dendritic cells is required for optimal T-cell priming.
We conclude that neither N-Myc nor L-Myc is likely to play important roles in long-term hair cell maintenance
Title: N-Myc and L-Myc are essential for hair cell formation but not maintenance.
L-Myc, as well as c-Myc mutants (W136E and dN2), all of which have little transformation activity, promoted human iPSC generation more efficiently and specifically compared with WT c-Myc.
Title: Promotion of direct reprogramming by transformation-deficient Myc.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Mycl1 (e-PCR), detects polymorphism
- UniSTS:226056

X13945 (e-PCR)
- UniSTS:159288

AW536278 (e-PCR)
- UniSTS:179062

Lmyc1 (e-PCR), detects polymorphism
- UniSTS:143787

Mycl1 (e-PCR), detects polymorphism
- UniSTS:547270

UniSTS:225258 (e-PCR)
- UniSTS:225258

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: protein L-Myc

Names: L-myc-1 proto-oncogene protein; lung carcinoma myc related oncogene 1; protein L-Myc-1; v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived; v-myc myelocytomatosis viral oncogene homolog, lung carcinoma derived

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303121.2 → NP_001290050.1 protein L-Myc isoform 2

Status: VALIDATED

Source sequence(s)

AL606906

UniProtKB/Swiss-Prot

P10166

Conserved Domains (2) summary

cd00083
Location:313 → 367

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam01056
Location:26 → 249

Myc_N; Myc amino-terminal region
NM_001421176.1 → NP_001408105.1 protein L-Myc isoform 3

Status: VALIDATED

Source sequence(s)

AL606906
NM_001421177.1 → NP_001408106.1 protein L-Myc isoform 1

Status: VALIDATED

Source sequence(s)

AL606906

UniProtKB/Swiss-Prot

P10166, Q5FWI7

UniProtKB/TrEMBL

Q3UIE0
NM_008506.4 → NP_032532.1 protein L-Myc isoform 1

See identical proteins and their annotated locations for NP_032532.1

Status: VALIDATED

Source sequence(s)

AL606906

Consensus CDS

CCDS18606.1

UniProtKB/Swiss-Prot

P10166, Q5FWI7

UniProtKB/TrEMBL

Q3UIE0

Related

ENSMUSP00000030407.8, ENSMUST00000030407.8

Conserved Domains (2) summary

pfam01056
Location:2 → 219

Myc_N; Myc amino-terminal region

cd11457
Location:280 → 368

bHLHzip_L-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins