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    Cul3 cullin 3 [ Mus musculus (house mouse) ]

    Gene ID: 26554, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cul3provided by MGI
    Official Full Name
    cullin 3provided by MGI
    Primary source
    MGI:MGI:1347360
    See related
    Ensembl:ENSMUSG00000004364 AllianceGenome:MGI:1347360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KIAA0617
    Summary
    Enables cyclin binding activity and identical protein binding activity. Involved in several processes, including embryonic cleavage; integrin-mediated signaling pathway; and regulation protein catabolic process at postsynapse. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including cerebral cortex; extraembryonic component; gonad; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.2), CNS E18 (RPKM 16.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cul3 in Genome Data Viewer
    Location:
    1 C5; 1 41.24 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (80242640..80318426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (80264923..80340690, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310015K22 gene Neighboring gene family with sequence similarity 124, member B Neighboring gene predicted gene, 57487 Neighboring gene STARR-seq mESC enhancer starr_01455 Neighboring gene STARR-seq mESC enhancer starr_01456 Neighboring gene predicted gene, 34098 Neighboring gene STARR-positive B cell enhancer ABC_E1998 Neighboring gene STARR-seq mESC enhancer starr_01458 Neighboring gene predicted gene, 39667 Neighboring gene STARR-positive B cell enhancer ABC_E11075 Neighboring gene GLE1 RNA export mediator pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables POZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables POZ domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin ligase complex scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin ligase complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in COPII vesicle coating ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic cleavage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within liver morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear protein quality control by the ubiquitin-proteasome system ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear protein quality control by the ubiquitin-proteasome system ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle phase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic metaphase/anaphase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within_positive_effect protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation protein catabolic process at postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation protein catabolic process at postsynapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation protein catabolic process at postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within trophectodermal cellular morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in polar microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in polar microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313728.2NP_001300657.1  cullin-3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161416, AC166157
      UniProtKB/TrEMBL
      E9Q4T8
      Conserved Domains (2) summary
      smart00884
      Location:644711
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:32614
      Cullin; Cullin family
    2. NM_001421384.1NP_001408313.1  cullin-3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161416, AC166157
    3. NM_001421385.1NP_001408314.1  cullin-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161416, AC166157
    4. NM_016716.6NP_057925.1  cullin-3 isoform 1

      See identical proteins and their annotated locations for NP_057925.1

      Status: VALIDATED

      Source sequence(s)
      AC161416, AC166157
      Consensus CDS
      CCDS15094.1
      UniProtKB/Swiss-Prot
      Q9JLV5
      UniProtKB/TrEMBL
      Q6ZQ84
      Related
      ENSMUSP00000130738.2, ENSMUST00000163119.8
      Conserved Domains (3) summary
      smart00182
      Location:421563
      CULLIN; Cullin
      pfam00888
      Location:35664
      Cullin; Cullin family
      pfam10557
      Location:700760
      Cullin_Nedd8; Cullin protein neddylation domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      80242640..80318426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254438.2XP_030110298.1  cullin-3 isoform X1

      UniProtKB/TrEMBL
      E9Q4T8
      Conserved Domains (2) summary
      smart00884
      Location:644711
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:32614
      Cullin; Cullin family
    2. XM_030254443.2XP_030110303.1  cullin-3 isoform X2

      UniProtKB/TrEMBL
      E9Q4T8
      Related
      ENSMUSP00000131891.2, ENSMUST00000164108.8
      Conserved Domains (2) summary
      smart00884
      Location:617684
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:5587
      Cullin; Cullin family