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    Zdhhc24 zinc finger, DHHC domain containing 24 [ Mus musculus (house mouse) ]

    Gene ID: 70605, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zdhhc24provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 24provided by MGI
    Primary source
    MGI:MGI:1917855
    See related
    Ensembl:ENSMUSG00000006463 AllianceGenome:MGI:1917855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Leng4; 5730496N17Rik
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including brain; early conceptus; endocrine gland; genitourinary system; and spinal cord mantle layer. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 20.6), ovary adult (RPKM 13.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc24 in Genome Data Viewer
    Location:
    19 A; 19 4.13 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4928696..4935425)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4878668..4885397)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cathepsin F Neighboring gene actinin alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E3236 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene STARR-seq mESC enhancer starr_45368 Neighboring gene dipeptidylpeptidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable palmitoyltransferase ZDHHC24
    Names
    DHHC-24
    leukocyte receptor cluster (LRC) member 4
    zinc finger DHHC domain-containing protein 24
    NP_001161988.1
    NP_001161989.1
    NP_081752.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168516.1 → NP_001161988.1  probable palmitoyltransferase ZDHHC24 isoform b

      See identical proteins and their annotated locations for NP_001161988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC141437, CA559443, CD354313
      UniProtKB/TrEMBL
      Q3TA22
      Related
      ENSMUST00000162088.8

    2. NM_001168517.1 → NP_001161989.1  probable palmitoyltransferase ZDHHC24 isoform b

      See identical proteins and their annotated locations for NP_001161989.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC141437
      UniProtKB/TrEMBL
      Q3TA22
      Related
      ENSMUST00000162134.2

    3. NM_027476.3 → NP_081752.2  probable palmitoyltransferase ZDHHC24 isoform a

      See identical proteins and their annotated locations for NP_081752.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC141437, AK171568
      Consensus CDS
      CCDS50353.1
      UniProtKB/Swiss-Prot
      Q3TAY4, Q3TDF1, Q3TF09, Q6IR37, Q9CS66
      Related
      ENSMUSP00000006632.8, ENSMUST00000006632.8
      Conserved Domains (1) summary
      pfam01529
      Location:95 → 232
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4928696..4935425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IR37.2 GenPept UniProtKB/Swiss-Prot:Q6IR37

    Gene LinkOut

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