IFNL2 interferon lambda 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFNL2provided by HGNC
Official Full Name: interferon lambda 2provided by HGNC
Primary source: HGNC:HGNC:18364
See related: Ensembl:ENSG00000183709 MIM:607401; AllianceGenome:HGNC:18364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL28A; IFNL2a; IFNL3a; IL-28A
Summary: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 19q13.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (39268396..39270188)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (42072661..42074453)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39759036..39760828)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lower level of IL-28A as a predictive index of the artificial liver support system in effective treatment of patients with HBV-ACLF.
Title: Lower level of IL-28A as a predictive index of the artificial liver support system in effective treatment of patients with HBV-ACLF.
Assessment of serum interleukin-28 as a biomarker to predict mortality in traumatic patients with sepsis.
Title: Assessment of serum interleukin-28 as a biomarker to predict mortality in traumatic patients with sepsis.
Serum IL-28A/IFN-lambda2 is linked to disease severity of COVID-19.
Title: Serum IL-28A/IFN-λ2 is linked to disease severity of COVID-19.
Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1.
Title: Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1.
A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells.
Title: A new transcription factor ATG10S activates IFNL2 transcription by binding at an IRF1 site in HepG2 cells.
Interleukin-29 and interleukin-28A induce migration of neutrophils in rheumatoid arthritis.
Title: Interleukin-29 and interleukin-28A induce migration of neutrophils in rheumatoid arthritis.
Linkage of Lambda Interferons in Protection Against Severe COVID-19.
Title: Linkage of Lambda Interferons in Protection Against Severe COVID-19.
IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro.
Title: IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro.
Type III interferons disrupt the lung epithelial barrier upon viral recognition.
Title: Type III interferons disrupt the lung epithelial barrier upon viral recognition.
Serum IL-28A levels were significantly elevated in patients with sepsis compared to healthy controls.
Title: Interleukin 28 is a potential therapeutic target for sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G64446 (e-PCR)
- UniSTS:163899

NoName (e-PCR)
- UniSTS:481128

SHGC-111908 (e-PCR)
- UniSTS:183193

NoName (e-PCR)
- UniSTS:485588

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	NAS Non-traceable Author Statement more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mucosal immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of immune response	IEA Inferred from Electronic Annotation more info
involved_in type III interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon lambda-2

Names: IFN-lambda-2; cytokine Zcyto20; interleukin 28A (interferon, lambda 2); interleukin-28A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.