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    Nubp1 nucleotide binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 26425, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nubp1provided by MGI
    Official Full Name
    nucleotide binding protein 1provided by MGI
    Primary source
    MGI:MGI:1347073
    See related
    Ensembl:ENSMUSG00000022503 AllianceGenome:MGI:1347073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable iron-sulfur cluster binding activity. Acts upstream of or within centrosome localization; negative regulation of centrosome duplication; and protein localization to cell cortex. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NUBP1 (NUBP iron-sulfur cluster assembly factor 1, cytosolic). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.6), whole brain E14.5 (RPKM 14.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nubp1 in Genome Data Viewer
    Location:
    16 A1; 16 5.61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10229802..10242317)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10411884..10424453)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30724 Neighboring gene tektin 5 Neighboring gene predicted gene, 41419 Neighboring gene STARR-positive B cell enhancer ABC_E10886 Neighboring gene trans-golgi network vesicle protein 23A Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10469529-10469712 Neighboring gene STARR-seq mESC enhancer starr_40087 Neighboring gene predicted gene, 41420 Neighboring gene STARR-positive B cell enhancer mm9_chr16:10487992-10488292 Neighboring gene class II transactivator Neighboring gene predicted gene, 57630

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent FeS chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables iron-sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron-sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cytosolic Fe-S cluster assembly factor NUBP1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011955.2NP_036085.1  cytosolic Fe-S cluster assembly factor NUBP1

      See identical proteins and their annotated locations for NP_036085.1

      Status: VALIDATED

      Source sequence(s)
      BI134234, BM938167, BU614991, CJ183745, CX210766
      Consensus CDS
      CCDS27948.1
      UniProtKB/Swiss-Prot
      Q3U053, Q7TMI1, Q9CRM5, Q9R060
      Related
      ENSMUSP00000023146.5, ENSMUST00000023146.5
      Conserved Domains (2) summary
      COG1192
      Location:49309
      BcsQ; Cellulose biosynthesis protein BcsQ [Cell motility]
      pfam10609
      Location:53303
      ParA; NUBPL iron-transfer P-loop NTPase

    RNA

    1. NR_190179.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122352

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10229802..10242317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)