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    Clca1 chloride channel accessory 1 [ Mus musculus (house mouse) ]

    Gene ID: 23844, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clca1provided by MGI
    Official Full Name
    chloride channel accessory 1provided by MGI
    Primary source
    MGI:MGI:1346342
    See related
    Ensembl:ENSMUSG00000028255 AllianceGenome:MGI:1346342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gob5; Clca2; Clca3; gob-5
    Summary
    Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in several processes, including calcium ion transport; cellular response to hypoxia; and chloride transmembrane transport. Predicted to act upstream of or within chloride transport. Located in membrane; microvillus; and secretory granule. Is expressed in genitourinary system; heart; intestine; retina; and thymus. Human ortholog(s) of this gene implicated in asthma and chronic obstructive pulmonary disease. Orthologous to human CLCA1 (chloride channel accessory 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 313.3), large intestine adult (RPKM 280.7) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Clca1 in Genome Data Viewer
    Location:
    3 H2; 3 69.26 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144710298..144738537, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145004537..145032776, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chloride channel accessory 4B Neighboring gene STARR-seq mESC enhancer starr_09186 Neighboring gene chloride channel accessory 4A Neighboring gene predicted gene, 35066 Neighboring gene STARR-seq mESC enhancer starr_09188 Neighboring gene chloride channel accessory 2 Neighboring gene STARR-seq mESC enhancer starr_09190 Neighboring gene STARR-seq mESC enhancer starr_09191 Neighboring gene STARR-positive B cell enhancer ABC_E1637 Neighboring gene predicted gene, 40163

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC143984, MGC143985

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity PubMed 
    enables intracellularly calcium-gated chloride channel activity  
    enables intracellularly calcium-gated chloride channel activity  
    enables metal ion binding  
    enables metallopeptidase activity  
    Process Evidence Code Pubs
    involved_in calcium ion transport  
    involved_in cellular response to hypoxia  
    involved_in chloride transmembrane transport  
    acts_upstream_of_or_within chloride transport PubMed 
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in extracellular region  
    located_in membrane PubMed 
    located_in microvillus PubMed 
    is_active_in plasma membrane  
    located_in secretory granule PubMed 
    located_in zymogen granule membrane  
    located_in zymogen granule membrane  

    General protein information

    Preferred Names
    calcium-activated chloride channel regulator 1
    Names
    calcium-activated chloride channel family member 3
    chloride channel calcium activated 1
    chloride channel calcium activated 2
    chloride channel calcium activated 3
    mCLCA3
    protein gob-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017474.2NP_059502.1  calcium-activated chloride channel regulator 1 precursor

      See identical proteins and their annotated locations for NP_059502.1

      Status: VALIDATED

      Source sequence(s)
      AK008659, AK033560
      Consensus CDS
      CCDS17889.1
      UniProtKB/Swiss-Prot
      O88826, Q8R049, Q9D7Z6
      Related
      ENSMUSP00000029919.6, ENSMUST00000029919.7
      Conserved Domains (2) summary
      cd00198
      Location:306459
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam08434
      Location:25907
      CLCA; Calcium-activated chloride channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144710298..144738537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501444.1XP_006501507.1  calcium-activated chloride channel regulator 1 isoform X1

      Conserved Domains (1) summary
      TIGR00868
      Location:1573
      hCaCC; calcium-activated chloride channel protein 1
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