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    Ddx52 DExD box helicase 52 [ Mus musculus (house mouse) ]

    Gene ID: 78394, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ddx52provided by MGI
    Official Full Name
    DExD box helicase 52provided by MGI
    Primary source
    MGI:MGI:1925644
    See related
    Ensembl:ENSMUSG00000020677 AllianceGenome:MGI:1925644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ROK1; 2700029C06Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in nucleolus. Is expressed in heart and limb. Orthologous to human DDX52 (DExD-box helicase 52). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.1), placenta adult (RPKM 9.6) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddx52 in Genome Data Viewer
    Location:
    11 C; 11 51.24 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83831659..83853914)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83942090..83963088)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8436 Neighboring gene predicted gene 12576 Neighboring gene STARR-positive B cell enhancer ABC_E3983 Neighboring gene STARR-positive B cell enhancer ABC_E7031 Neighboring gene HNF1 homeobox B Neighboring gene STARR-seq mESC enhancer starr_30206 Neighboring gene STARR-seq mESC enhancer starr_30207 Neighboring gene predicted gene, 51869 Neighboring gene STARR-positive B cell enhancer ABC_E5256 Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene dual specificity phosphatase 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Mori AD, et al. Dev Biol, 2006 Sep 15. PMID 16870172
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX52
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
    DEAD box protein 52
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 52
    NP_084372.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030096.2 → NP_084372.2  probable ATP-dependent RNA helicase DDX52

      See identical proteins and their annotated locations for NP_084372.2

      Status: VALIDATED

      Source sequence(s)
      AK141200, AK166789, AL645615, CJ142321, CN539261
      Consensus CDS
      CCDS25180.1
      UniProtKB/Swiss-Prot
      Q3UZY9, Q8BV29, Q8K301
      UniProtKB/TrEMBL
      Q3TKX4
      Related
      ENSMUSP00000048802.8, ENSMUST00000049257.8
      Conserved Domains (3) summary
      PRK11192
      Location:163 → 597
      PRK11192; ATP-dependent RNA helicase SrmB; Provisional
      pfam00271
      Location:399 → 508
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:170 → 376
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83831659..83853914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004937057.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K301.2 GenPept UniProtKB/Swiss-Prot:Q8K301

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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