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    Micos10 mitochondrial contact site and cristae organizing system subunit 10 [ Mus musculus (house mouse) ]

    Gene ID: 433771, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Micos10provided by MGI
    Official Full Name
    mitochondrial contact site and cristae organizing system subunit 10provided by MGI
    Primary source
    MGI:MGI:1913628
    See related
    Ensembl:ENSMUSG00000050608 AllianceGenome:MGI:1913628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Minos1; 2310028O11Rik
    Summary
    Predicted to be involved in cristae formation. Located in mitochondrion. Orthologous to human MICOS10 (mitochondrial contact site and cristae organizing system subunit 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 24.4), heart adult (RPKM 23.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Micos10 in Genome Data Viewer
    Location:
    4 D3; 4 70.57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138829125..138858667, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139101814..139131113, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 6 Neighboring gene STARR-positive B cell enhancer ABC_E4693 Neighboring gene NBL1, DAN family BMP antagonist Neighboring gene STARR-positive B cell enhancer ABC_E9606 Neighboring gene predicted gene, 33304 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 4 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138725170-138725470 Neighboring gene predicted gene 16287

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cristae formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit Mic10
    Names
    UPF0327 protein C1orf151 homolog
    mitochondrial inner membrane organizing system 1
    mitochondrial inner membrane organizing system protein 1
    novel DUF543 domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163006.2 → NP_001156478.1  MICOS complex subunit Mic10

      See identical proteins and their annotated locations for NP_001156478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the conserved protein.
      Source sequence(s)
      AK030343, AL807811, BF465511
      Consensus CDS
      CCDS51339.1
      UniProtKB/Swiss-Prot
      A2ALL2, Q3U6N5, Q7TNS2
      Related
      ENSMUSP00000117583.2, ENSMUST00000143971.2
      Conserved Domains (1) summary
      pfam04418
      Location:1 → 62
      DUF543; Domain of unknown function (DUF543)

    RNA

    1. NR_033745.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA023452, AK030343, AL807811, AW226897, BF465511

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138829125..138858667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004941931.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNS2.1 GenPept UniProtKB/Swiss-Prot:Q7TNS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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