L3mbtl3 L3MBTL3 histone methyl-lysine binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: L3mbtl3provided by MGI
Official Full Name: L3MBTL3 histone methyl-lysine binding proteinprovided by MGI
Primary source: MGI:MGI:2143628
See related: Ensembl:ENSMUSG00000039089 AllianceGenome:MGI:2143628
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBT-1
Summary: Predicted to enable several functions, including histone binding activity; identical protein binding activity; and methylation-dependent protein binding activity. Involved in regulation of ubiquitin-dependent protein catabolic process. Acts upstream of or within erythrocyte maturation; granulocyte differentiation; and macrophage differentiation. Located in nucleus. Is expressed in retina. Orthologous to human L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 9.7), CNS E18 (RPKM 6.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 13.67 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (26150361..26252426, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (26274461..26376036, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The direct binding of L3MBTL3 to the methylated SOX2 protein leads to the recruitment of the CRL4(DCAF5) ubiquitin E3 ligase to target SOX2 protein for ubiquitin-dependent proteolysis.
Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
L3MBTL3 binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1.
Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
The mouse MBT-1 protein influences myelopoiesis by transiently enhancing p57(KIP2) expression levels.
Title: Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236321

AU022077 (e-PCR)
- UniSTS:208504

AI481284 (e-PCR)
- UniSTS:159963

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methylation-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables methylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within granulocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription initiation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lethal(3)malignant brain tumor-like protein 3

Names: l(3)mbt-like 3; l(3)mbt-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347467.3 → NP_001334396.1 lethal(3)malignant brain tumor-like protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC091763, AC152953

Consensus CDS

CCDS83689.1

UniProtKB/Swiss-Prot

Q8BLB7

Related

ENSMUSP00000101158.4, ENSMUST00000105519.10

Conserved Domains (2) summary

cd09582
Location:783 → 848

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:426 → 518

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
NM_001359254.2 → NP_001346183.1 lethal(3)malignant brain tumor-like protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC091763, AC152953

Consensus CDS

CCDS23756.1

UniProtKB/Swiss-Prot

Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4

Related

ENSMUSP00000037619.7, ENSMUST00000040219.13

Conserved Domains (3) summary

cd09582
Location:808 → 873

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:451 → 543

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

pfam01530
Location:558 → 586

zf-C2HC; Zinc finger, C2HC type
NM_001359255.2 → NP_001346184.1 lethal(3)malignant brain tumor-like protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC091763, AC152953

Conserved Domains (2) summary

cd09582
Location:732 → 797

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:375 → 467

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
NM_001408257.1 → NP_001395186.1 lethal(3)malignant brain tumor-like protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC091763, AC152953

UniProtKB/Swiss-Prot

Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4
NM_001408258.1 → NP_001395187.1 lethal(3)malignant brain tumor-like protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC091763, AC152953
NM_001408259.1 → NP_001395188.1 lethal(3)malignant brain tumor-like protein 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC091763, AC152953
NM_172787.4 → NP_766375.1 lethal(3)malignant brain tumor-like protein 3 isoform 1

See identical proteins and their annotated locations for NP_766375.1

Status: VALIDATED

Source sequence(s)

AC091763, AC152953

Consensus CDS

CCDS23756.1

UniProtKB/Swiss-Prot

Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4

Related

ENSMUSP00000133479.2, ENSMUST00000174766.2

Conserved Domains (3) summary

cd09582
Location:808 → 873

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:451 → 543

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

pfam01530
Location:558 → 586

zf-C2HC; Zinc finger, C2HC type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

26150361..26252426 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155774.1 → XP_036011667.1 lethal(3)malignant brain tumor-like protein 3 isoform X4

Conserved Domains (2) summary

cd09582
Location:732 → 797

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:375 → 467

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_030245082.2 → XP_030100942.1 lethal(3)malignant brain tumor-like protein 3 isoform X3

Conserved Domains (2) summary

cd09582
Location:757 → 822

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:400 → 492

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_036155772.1 → XP_036011665.1 lethal(3)malignant brain tumor-like protein 3 isoform X2

Conserved Domains (2) summary

cd09582
Location:783 → 848

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:426 → 518

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_006512733.4 → XP_006512796.1 lethal(3)malignant brain tumor-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_006512796.1

UniProtKB/Swiss-Prot

Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4

Conserved Domains (3) summary

cd09582
Location:808 → 873

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:451 → 543

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

pfam01530
Location:558 → 586

zf-C2HC; Zinc finger, C2HC type
XM_030245083.2 → XP_030100943.1 lethal(3)malignant brain tumor-like protein 3 isoform X4

Conserved Domains (2) summary

cd09582
Location:732 → 797

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:375 → 467

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
XM_030245081.2 → XP_030100941.1 lethal(3)malignant brain tumor-like protein 3 isoform X2

Conserved Domains (2) summary

cd09582
Location:783 → 848

SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group

smart00561
Location:426 → 518

MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2