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    Crtc3 CREB regulated transcription coactivator 3 [ Mus musculus (house mouse) ]

    Gene ID: 70461, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crtc3provided by MGI
    Official Full Name
    CREB regulated transcription coactivator 3provided by MGI
    Primary source
    MGI:MGI:1917711
    See related
    Ensembl:ENSMUSG00000030527 AllianceGenome:MGI:1917711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TORC3; 2610312F20Rik; 6332415K15Rik
    Summary
    Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Involved in positive regulation of CREB transcription factor activity. Acts upstream of or within several processes, including energy homeostasis; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Orthologous to human CRTC3 (CREB regulated transcription coactivator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 17.1), ovary adult (RPKM 16.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Crtc3 in Genome Data Viewer
    Location:
    7 D2- D3; 7 45.65 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80236375..80339443, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80586627..80688948, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Bloom syndrome, RecQ like helicase Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1b Neighboring gene STARR-positive B cell enhancer ABC_E874 Neighboring gene STARR-seq mESC enhancer starr_19330 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87699700-87699906 Neighboring gene predicted gene, 42398 Neighboring gene STARR-seq mESC enhancer starr_19331 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87792406-87792515 Neighboring gene predicted gene 15880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87812125-87812234 Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6567 Neighboring gene STARR-seq mESC enhancer starr_19336 Neighboring gene predicted gene, 18392 Neighboring gene VISTA enhancer mm170 Neighboring gene STARR-positive B cell enhancer ABC_E10447 Neighboring gene STARR-seq mESC enhancer starr_19340 Neighboring gene STARR-positive B cell enhancer ABC_E11358 Neighboring gene STARR-seq mESC enhancer starr_19343 Neighboring gene STARR-positive B cell enhancer ABC_E552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88009760-88009913 Neighboring gene zinc finger and SCAN domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC19083

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP response element binding protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP response element binding protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CREB-regulated transcription coactivator 3
    Names
    TORC-3
    transducer of CREB protein 3
    transducer of regulated cAMP response element-binding protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173863.3NP_776288.2  CREB-regulated transcription coactivator 3

      See identical proteins and their annotated locations for NP_776288.2

      Status: VALIDATED

      Source sequence(s)
      AC127594
      Consensus CDS
      CCDS21398.2
      UniProtKB/Swiss-Prot
      Q91X84
      Related
      ENSMUSP00000113540.2, ENSMUST00000122255.8
      Conserved Domains (3) summary
      pfam12884
      Location:1164
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:159321
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:545619
      TORC_C; Transducer of regulated CREB activity, C terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80236375..80339443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242981.2XP_030098841.1  CREB-regulated transcription coactivator 3 isoform X2

      Conserved Domains (3) summary
      PRK10263
      Location:88234
      PRK10263; DNA translocase FtsK; Provisional
      pfam12885
      Location:122
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:246320
      TORC_C; Transducer of regulated CREB activity, C-terminus
    2. XM_006541195.4XP_006541258.1  CREB-regulated transcription coactivator 3 isoform X1

      Conserved Domains (4) summary
      PRK10263
      Location:386532
      PRK10263; DNA translocase FtsK; Provisional
      pfam12884
      Location:1164
      TORC_N; Transducer of regulated CREB activity, N-terminus
      pfam12885
      Location:159320
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:544618
      TORC_C; Transducer of regulated CREB activity, C-terminus