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    Apool apolipoprotein O-like [ Mus musculus (house mouse) ]

    Gene ID: 68117, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Apoolprovided by MGI
    Official Full Name
    apolipoprotein O-likeprovided by MGI
    Primary source
    MGI:MGI:1915367
    See related
    Ensembl:ENSMUSG00000025525 AllianceGenome:MGI:1915367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Micos27; 6720473G16Rik; 9430083G14Rik; E130106L15Rik
    Summary
    Predicted to be involved in cristae formation. Located in mitochondrial inner membrane. Orthologous to human APOOL (apolipoprotein O like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 9.6), CNS E11.5 (RPKM 9.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apool in Genome Data Viewer
    Location:
    X E1; X 48.76 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (111221049..111282452)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (112311352..112372755)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene testis expressed gene 16 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene barrier to autointegration factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47777 Neighboring gene spermidine/spermine N1-acetyl transferase-like 1 Neighboring gene ubinuclein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    2. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit Mic27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313733.1 → NP_001300662.1  MICOS complex subunit Mic27 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AI132704, AK012398, DV061158
      UniProtKB/TrEMBL
      Q9CZB4
      Conserved Domains (1) summary
      pfam09769
      Location:37 → 174
      ApoO; Apolipoprotein O

    2. NM_001313734.1 → NP_001300663.1  MICOS complex subunit Mic27 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI132704, AI587915, AK012398, DV061158
      Consensus CDS
      CCDS85799.1
      UniProtKB/TrEMBL
      B1AV14
      Related
      ENSMUSP00000109042.2, ENSMUST00000113415.2
      Conserved Domains (1) summary
      pfam09769
      Location:7 → 121
      ApoO; Apolipoprotein O

    3. NM_026565.3 → NP_080841.1  MICOS complex subunit Mic27 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080841.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI132704, AK012398, DV061158
      Consensus CDS
      CCDS30359.1
      UniProtKB/Swiss-Prot
      Q78IK4
      UniProtKB/TrEMBL
      Q9CZB4
      Related
      ENSMUSP00000026599.4, ENSMUST00000026599.10
      Conserved Domains (1) summary
      pfam09769
      Location:42 → 179
      ApoO; Apolipoprotein O

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      111221049..111282452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78IK4.1 GenPept UniProtKB/Swiss-Prot:Q78IK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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